Publications by authors named "Lance Hellman"

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A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry.
Nishant K Singh, Jesus A Alonso, Jason R Devlin, Grant L J Keller, George I Gray, Lance M Hellman

Nat Commun· November 2022

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Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma.
Chang Liu, Hong Liu, Moumita Dasgupta, Lance M Hellman, Xiaogang Zhang

Sci Rep· July 2022

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Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor.
Jiaqi Ma, Cory M Ayres, Lance M Hellman, Jason R Devlin, Brian M Baker

J Biol Chem· August 2021

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Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner.
Angela R Smith, Jesus A Alonso, Cory M Ayres, Nishant K Singh, Lance M Hellman

Proc Natl Acad Sci U S A· January 2021

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An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes.
Nishant K Singh, Jesus A Alonso, Daniel T Harris, Scott D Anderson, Jiaqi Ma, Lance M Hellman

Biochemistry· November 2020

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Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility.
Cory M Ayres, Esam T Abualrous, Alistair Bailey, Christian Abraham, Lance M Hellman

Front Immunol· October 2020

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Improving T Cell Receptor On-Target Specificity via Structure-Guided Design.
Lance M Hellman, Kendra C Foley, Nishant K Singh, Jesus A Alonso, Timothy P Riley

Mol Ther· February 2019

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T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability.
Timothy P Riley, Lance M Hellman, Marvin H Gee, Juan L Mendoza, Jesus A Alonso

Nat Chem Biol· October 2018

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Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells.
Timothy T Spear, Yuan Wang, Thomas W Smith, Patricia E Simms, Elizabeth Garrett-Mayer, Lance M Hellman

Mol Ther· April 2018

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Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells.
Tamson Moore, Courtney Regan Wagner, Gina M Scurti, Kelli A Hutchens, Constantine Godellas, Lance M Hellman

Cancer Immunol Immunother· February 2018

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Correction to: Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells.
Tamson Moore, Courtney Regan Wagner, Gina M Scurti, Kelli A Hutchens, Constantine Godellas, Lance M Hellman

Cancer Immunol Immunother· February 2018

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Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells.
Timothy T Spear, Yuan Wang, Kendra C Foley, David C Murray, Gina M Scurti, Lance M Hellman

Cancer Immunol Immunother· November 2017

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How an alloreactive T-cell receptor achieves peptide and MHC specificity.
Yuan Wang, Nishant K Singh, Timothy T Spear, Lance M Hellman, Kurt H Piepenbrink

Proc Natl Acad Sci U S A· June 2017

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Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa.
David A Dik, Teresa Domínguez-Gil, Mijoon Lee, Dusan Hesek, Byungjin Byun, Lance M Hellman

J Am Chem Soc· February 2017

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A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces.
Timothy P Riley, Cory M Ayres, Lance M Hellman, Nishant K Singh, Michael Cosiano

Protein Eng Des Sel· December 2016

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Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability.
Timothy T Spear, Timothy P Riley, Gretchen E Lyons, Glenda G Callender, Jeffrey J Roszkowski, Lance M Hellman

J Leukoc Biol· September 2016

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Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes.
Lance M Hellman, Liusong Yin, Yuan Wang, Sydney J Blevins, Timothy P Riley

J Immunol Methods· May 2016

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Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion.
Michael C Chicka, Qiansheng Ren, David Richards, Lance M Hellman, Jinchao Zhang

Biochem J· March 2016

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FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function.
Matthew G Thompson, Michelle Larson, Amy Vidrine, Kelly Barrios, Flor Navarro, Lance M Hellman

J Immunol· December 2015

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Structural mechanism of laforin function in glycogen dephosphorylation and lafora disease.
Madushi Raththagala, M Kathryn Brewer, Matthew W Parker, Amanda R Sherwood, Brian K Wong, Lance M Hellman

Mol Cell· January 2015

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Repair of O6-methylguanine adducts in human telomeric G-quadruplex DNA by O6-alkylguanine-DNA alkyltransferase.
Lance M Hellman, Tyler J Spear, Colton J Koontz, Manana Melikishvili, Michael G Fried

Nucleic Acids Res· September 2014

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Computational design of the affinity and specificity of a therapeutic T cell receptor.
Brian G Pierce, Lance M Hellman, Moushumi Hossain, Nishant K Singh, Craig W Vander Kooi

PLoS Comput Biol· February 2014

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Trimeric transmembrane domain interactions in paramyxovirus fusion proteins: roles in protein folding, stability, and function.
Everett Clinton Smith, Stacy E Smith, James R Carter, Stacy R Webb, Kathleen M Gibson, Lance M Hellman

J Biol Chem· December 2013

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Cell-wall remodeling by the zinc-protease AmpDh3 from Pseudomonas aeruginosa.
Mijoon Lee, Cecilia Artola-Recolons, César Carrasco-López, Siseth Martínez-Caballero, Dusan Hesek, Lance M Hellman

J Am Chem Soc· August 2013

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Reaction products and the X-ray structure of AmpDh2, a virulence determinant of Pseudomonas aeruginosa.
Siseth Martínez-Caballero, Mijoon Lee, Cecilia Artola-Recolons, César Carrasco-López, Dusan Hesek, Lance M Hellman

J Am Chem Soc· July 2013

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