Publications by authors named "Lee A Applegate"

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Preclinical Mechanistic Evaluation of Hyaluronan/Niacinamide (Vitamin B3) Hydrogels: Toward an Enhanced Viscosupplement System with Ancillary Anti-Arthritic Attributes.
Farid Hadjab, Stivens Antoine, Béatrice Hamel, Mohamed Benderdour, Hassan Fahmi, Lee Ann Applegate

Bioengineering (Basel)· November 2025

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Development of image analysis tool to evaluate Langerhans cell migration after exposure to isothiazolinones.
Christelle Oltramare, Olivier Burri, Nancy B Hopf, Sandra Jaccoud, Arne Seitz, Lee Ann Applegate

Arch Toxicol· June 2025

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Clinical Safety and Efficacy of Hyaluronic Acid-Niacinamide-Tranexamic Acid Injectable Hydrogel for Multifactorial Facial Skin Quality Enhancement with Dark Skin Lightening.
Sarah Hsin, Kelly Lourenço, Alexandre Porcello, Michèle Chemali, Cíntia Marques, Lee Ann Applegate

Gels· June 2025

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Bicomponent Cutaneous Cell Therapy for Early Burn Care: Manufacturing Homogeneity and Epidermis-Structuring Functions of Clinical Grade FE002-SK2 Allogeneic Dermal Progenitor Fibroblasts.
Xi Chen, Nathalie Hirt-Burri, Corinne Scaletta, Alexis E Laurent, Lee Ann Applegate

Pharmaceutics· May 2025

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In Vitro Evaluation and Clinical Effects of a Regenerative Complex with Non-Cross-Linked Hyaluronic Acid and a High-Molecular-Weight Polynucleotide for Periorbital Treatment.
Hanadi Sami Abuyousif, Alexandre Porcello, Marco Cerrano, Cíntia Marques, Corinne Scaletta, Lee Ann Applegate

Polymers (Basel)· February 2025

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From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules.
Cíntia Marques, Alexandre Porcello, Marco Cerrano, Farid Hadjab, Michèle Chemali, Lee Ann Applegate

Biomolecules· January 2025

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Optimization and Standardization of Stable De-Epidermized Dermis (DED) Models for Functional Evaluation of Cutaneous Cell Therapies.
Xi Chen, Corinne Scaletta, Zhifeng Liao, Alexis Laurent, Lee Ann Applegate

Bioengineering (Basel)· December 2024

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Reassessing Long-Term Cryopreservation Strategies for Improved Quality, Safety, and Clinical Use of Allogeneic Dermal Progenitor Cells.
Marjorie Flahaut, Alexis Laurent, Carla V Fuenteslópez, Zhanfeng Cui, Hua Ye, Lee Ann Applegate

J Invest Dermatol· October 2024

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An Adhesive Hydrogel Technology for Enhanced Cartilage Repair: A Preliminary Proof of Concept.
Peyman Karami, Robin Martin, Alexis Laurent, Hui Yin Nam, Virginie Philippe, Lee Ann Applegate

Gels· October 2024

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Cartilage Repair: Promise of Adhesive Orthopedic Hydrogels.
Peyman Karami, Alexis Laurent, Virginie Philippe, Lee Ann Applegate, Dominique P Pioletti

Int J Mol Sci· September 2024

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Banked Primary Progenitor Cells for Allogeneic Intervertebral Disc (IVD) Therapy: Preclinical Qualification and Functional Optimization within a Cell Spheroid Formulation Process.
Annick Jeannerat, Cédric Peneveyre, Sandra Jaccoud, Virginie Philippe, Corinne Scaletta, Lee Ann Applegate

Pharmaceutics· September 2024

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Prognostic Factors for Multiligament Knee Injury Treated With Multiligament Reconstruction: Functional and Radiological Outcomes at 2 to 8 Years Postoperatively.
Valentine Schneebeli, Virginie Philippe, Alexis Laurent, Lee Ann Applegate, Robin Martin

Orthop J Sports Med· August 2024

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Sustainable Primary Cell Banking for Topical Compound Cytotoxicity Assays: Protocol Validation on Novel Biocides and Antifungals for Optimized Burn Wound Care.
Zhifeng Liao, Nicolas Laurent, Nathalie Hirt-Burri, Corinne Scaletta, Philippe Abdel-Sayed, Lee Ann Applegate

Eur Burn J· August 2024

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Dual Functionalization of Hyaluronan Dermal Fillers with Vitamin B3: Efficient Combination of Bio-Stimulation Properties with Hydrogel System Resilience Enhancement.
Alexandre Porcello, Michèle Chemali, Cíntia Marques, Corinne Scaletta, Kelly Lourenço, Lee Ann Applegate

Gels· May 2024

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Comprehensive Evaluation of Injectability Attributes in OxiFree™ Dermal Fillers: MaiLi Product Variants and Clinical Case Reports.
Patrick Micheels, Alexandre Porcello, Thierry Bezzola, Daniel Perrenoud, Marie-Odile Christen, Lee Ann Applegate

Gels· April 2024

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A New Ex Vivo Human Skin Burn Model.
Ania Labouchère, Daniel Haselbach, Murielle Michetti, Catherine Pythoud, Wassim Raffoul, Lee Ann Applegate

J Burn Care Res· March 2024

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Streamlined, single-step non-viral CRISPR-Cas9 knockout strategy enhances gene editing efficiency in primary human chondrocyte populations.
Simone Ponta, Angela Bonato, Philipp Neidenbach, Valentino F Bruhin, Alexis Laurent, Lee Ann Applegate

Arthritis Res Ther· March 2024

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Mechanistic Insights into the Multiple Functions of Niacinamide: Therapeutic Implications and Cosmeceutical Applications in Functional Skincare Products.
Cíntia Marques, Farid Hadjab, Alexandre Porcello, Kelly Lourenço, Corinne Scaletta, Lee Ann Applegate

Antioxidants (Basel)· March 2024

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Ex Vivo Functional Benchmarking of Hyaluronan-Based Osteoarthritis Viscosupplement Products: Comprehensive Assessment of Rheological, Lubricative, Adhesive, and Stability Attributes.
Alexandre Porcello, Farid Hadjab, Maryam Ajouaou, Virginie Philippe, Robin Martin, Lee Ann Applegate

Gels· October 2023

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Cutaneous Cell Therapy Manufacturing Timeframe Rationalization: Allogeneic Off-the-Freezer Fibroblasts for Dermo-Epidermal Combined Preparations (DE-FE002-SK2) in Burn Care.
Xi Chen, Alexis Laurent, Zhifeng Liao, Sandra Jaccoud, Philippe Abdel-Sayed, Lee Ann Applegate

Pharmaceutics· September 2023

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Autologous and Allogeneic Cytotherapies for Large Knee (Osteo)Chondral Defects: Manufacturing Process Benchmarking and Parallel Functional Qualification.
Virginie Philippe, Annick Jeannerat, Cédric Peneveyre, Sandra Jaccoud, Corinne Scaletta, Lee Ann Applegate

Pharmaceutics· September 2023

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Bio-Enhanced Neoligaments Graft Bearing FE002 Primary Progenitor Tenocytes: Allogeneic Tissue Engineering & Surgical Proofs-of-Concept for Hand Ligament Regenerative Medicine.
Annick Jeannerat, Joachim Meuli, Cédric Peneveyre, Sandra Jaccoud, Michèle Chemali, Lee Ann Applegate

Pharmaceutics· July 2023

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Thermo-Responsive Hyaluronan-Based Hydrogels Combined with Allogeneic Cytotherapeutics for the Treatment of Osteoarthritis.
Alexandre Porcello, Paula Gonzalez-Fernandez, Annick Jeannerat, Cédric Peneveyre, Philippe Abdel-Sayed, Lee Ann Applegate

Pharmaceutics· May 2023

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Process Optimization and Efficacy Assessment of Standardized PRP for Tendinopathies in Sports Medicine: Retrospective Study of Clinical Files and GMP Manufacturing Records in a Swiss University Hospital.
Patrick Sebbagh, Nathalie Hirt-Burri, Corinne Scaletta, Philippe Abdel-Sayed, Wassim Raffoul, Lee Ann Applegate

Bioengineering (Basel)· March 2023

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Current Status of PRP Manufacturing Requirements & European Regulatory Frameworks: Practical Tools for the Appropriate Implementation of PRP Therapies in Musculoskeletal Regenerative Medicine.
Patrick Sebbagh, Alessandro Cannone, Gerald Gremion, Vincent Gremeaux, Wassim Raffoul, Lee Ann Applegate

Bioengineering (Basel)· February 2023

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