Publications by authors named "Lee Marcus"

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Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum.
Henrico Langeveld, Keletso Maepa, Marché Maree, Jessica L Thibaud, Nicolaas Salomane, Marcus C S Lee

Angew Chem Int Ed Engl· December 2025

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MK-7602: a potent multi-stage dual-targeting antimalarial.
Paola Favuzza, Josephine Palandri, Manuel de Lera Ruiz, Wendy Bailey, Christopher W Boyce, Marcus C S Lee

EBioMedicine· December 2025

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Reverse versus anatomic total shoulder arthroplasty in patients over 70 with a competent rotator cuff and glenohumeral osteoarthritis: a meta-analysis.
Mayek S Gupta, Ashma Krishan, Abbas Rashid, Marcus H Lee

J Shoulder Elbow Surg· November 2025

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Mechanistic insights into dual-active liver and blood-stage antiplasmodials.
Mukul Rawat, Nonlawat Boonyalai, Cindy Smidt, Madeline R Luth, Daisy Chen, Marcus C S Lee

mBio· November 2025

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Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in HSP90 Inhibitors.
Fu-Hsuan Ko, Amanda K Lukens, Mariana Laureano de Souza, Alex Foy, Jason Hsiao, Marcus Lee

bioRxiv· November 2025

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Optimization of 2,8-Diaryl-1,5-naphthyridines as Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy.
Godwin A Dziwornu, Donald Seanego, Stephen Fienberg, Venkata S Sypu, Nicolaas Salomane, Marcus C S Lee

J Med Chem· October 2025

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Non-parallel impacts of predators on the evolution of colouration plasticity in Trinidadian killifish.
Marcus Lee, Matthew R Walsh

Evolution· October 2025

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Unlocking the potential of video-based markerless motion analysis to study world-class sporting performance.
Desmond Boey, Olivier Girard, Marcus Lee, Bruce Elliott, Machar Reid

J Sports Sci· October 2025

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Protocol for a human placental explant model to study acute responses to pathogens.
Elias R Ruiz-Morales, Regina Hoo, Ross F Waller, Marcus C S Lee, David Fernandez-Antoran

STAR Protoc· September 2025

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Intergenerational effects of dietary changes on trait means and variance.
Marcus Lee, Kevin Tran, Yasmine Castillo, Matthew R Walsh

Biol Lett· September 2025

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Optimization and Characterization of the Antimalarial Activity of -Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1.
William Nguyen, Coralie Boulet, Madeline G Dans, Katie Loi, Kate E Jarman, Marcus C S Lee

J Med Chem· August 2025

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Mechanistic Insights into Dual-Active Liver and Blood-Stage Antiplasmodials.
Mukul Rawat, Nonlawat Boonyalai, Cindy Smidt, Madeline R Luth, Daisy Chen, Marcus C S Lee

bioRxiv· August 2025

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Novel Inhibitors of Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and Efficacy in a Humanized Mouse Malaria Infection Model.
Godwin A Dziwornu, Mmakwena M Mmonwa, Dina Coertzen, Liezl Krugmann, Nicolaas Salomane, Marcus C S Lee

J Med Chem· August 2025

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Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity.
Flore Nardella, Tiantian Jiang, Lushun Wang, Monica J Bohmer, Subhoja Chakraborty, Marcus C S Lee

Cell Chem Biol· July 2025

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The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against via Dual Inhibition of Ark1 and Hemozoin Formation.
Kathryn J Wicht, John G Woodland, Larnelle F Garnie, Henrico Langeveld, Dale Taylor, Marcus C S Lee

bioRxiv· July 2025

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Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.
Jon Kyle Awalt, Zi Kang Ooi, Trent D Ashton, Mahta Mansouri, Petar P S Calic, Marcus C S Lee

J Med Chem· April 2025

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Drug resistance-associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity.
Cameron J Smith, Heledd Eavis, Carla Briggs, Ryan Henrici, Maryia Karpiyevich, Marcus C S Lee

J Biol Chem· March 2025

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Revisiting the druggable genome using predicted structures and data mining.
Karla P Godinez-Macias, Daisy Chen, J Lincoln Wallis, Miles G Siegel, Anna Adam, Marcus C S Lee

NPJ Drug Discov· March 2025

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Assessing the Wrightington Classification System for elbow fracture-dislocations : an external reliability study.
Shannon Tse, An-Sofie Van de Kelft, Samuel K Simister, Danielle A Forster, Marcus Lee

Bone Joint J· February 2025

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Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity.
Mukul Rawat, Gilda Padalino, Edem Adika, John Okombo, Tomas Yeo, Marcus C S Lee

PLoS Pathog· February 2025

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YAT2150 is irresistible in Plasmodium falciparum and active against Plasmodium vivax and Leishmania clinical isolates.
Inés Bouzón-Arnáiz, Mukul Rawat, Rachael Coyle, Lionel Brice Feufack-Donfack, Malen Ea, Marcus C S Lee

Sci Rep· January 2025

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Variable stressor exposure shapes fitness within and across generations.
Marcus Lee

Sci Rep· January 2025

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Systematic in vitro evolution in reveals key determinants of drug resistance.
Madeline R Luth, Karla P Godinez-Macias, Daisy Chen, John Okombo, Vandana Thathy, Marcus C S Lee

Science· November 2024

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Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining.
Karla P Godinez-Macias, Daisy Chen, J Lincoln Wallis, Miles G Siegel, Anna Adam, Marcus C S Lee

Res Sq· November 2024

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A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants.
Letícia Tiburcio Ferreira, Gustavo Capatti Cassiano, Luis Carlos Salazar Alvarez, John Okombo, Juliana Calit, Marcus C S Lee

PLoS Pathog· October 2024

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