Publications by authors named "Lynn MacDonald"

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Interplay of procoagulatory and neutrophil-derived anticoagulatory proteins in C1q-NET-driven blood coagulation.
Minnah Thomas, Davor Frleta, KehDih Lai, John O'Brien, Aditi K Patel, Lynn E Macdonald

Blood· December 2025

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Functional, sustained recovery of hearing in Otoferlin-deficient mice using DB-OTO, a hair-cell-specific AAV-based gene therapy.
Yoojin Chung, Seth D Koehler, Sarah Cancelarich, Tyler M Gibson, Gabriela Pregernig, Lynn E Macdonald

Mol Ther Methods Clin Dev· December 2025

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The Effects of Fasinumab on Peripheral Nerve Function and Ganglion Anatomy: Results From a Randomized, Double-Blind, Placebo-Controlled Study in Patients With Pain Due to Osteoarthritis of the Knee or Hip, and a Series of Nonclinical Studies.
Simon Eng, Michael Fetell, Haitao Gao, Jingning Mei, Jesus Trejos, Lynn E Macdonald

Curr Ther Res Clin Exp· December 2025

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Bridging Frameworks: A Comparison of Occupational Health and Safety's Hierarchy of Controls and the International System of Radiological Protection.
T Lynn MacDonald

Health Phys· August 2025

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A rare variant in associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice.
Bradley R Miller, Claudia Gonzaga-Jauregui, Karlla W Brigatti, Job de Jong, Robert S Breese, Lynn E Macdonald

Proc Natl Acad Sci U S A· April 2025

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CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivo.
Robert Salzler, David J DiLillo, Kei Saotome, Kevin Bray, Katja Mohrs, Douglas MacDonald, Lynn E Macdonald

Sci Transl Med· March 2025

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Peripheral human red blood cell development in human immune system mouse model with heme oxygenase-1 deficiency.
Aditi Khatri Patel, Kyle Trageser, Hyunjin Kim, Weikeat Lim, Christina Adler, Lynn Macdonald

Blood Adv· December 2024

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A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies.
Jiaxi Wu, Nicolin Bloch, Aaron Y Chang, Ramandeep Bhavsar, Qingqing Wang, Lynn Macdonald

Cell Rep Med· October 2024

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A monoclonal antibody collection for C. difficile typing ?
Lise Hunault, Patrick England, Frédéric Barbut, Bruno Iannascoli, Ophélie Godon, Lynn Macdonald

Gut Pathog· January 2024

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Anti-S-layer monoclonal antibodies impact physiology.
Lise Hunault, Emile Auria, Patrick England, Julien Deschamps, Romain Briandet, Lynn Macdonald

Gut Microbes· January 2024

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Microenvironment-dependent growth of Sezary cells in humanized IL-15 mice.
Jie Gao, Shumei Ren, Gabrielle Choonoo, Guoying Chen, Davor Frleta, Lynn Macdonald

Dis Model Mech· October 2023

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Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain.
Selin Somersan-Karakaya, Kenneth C Turner, Luz Cortes-Burgos, Jutta Miller, Michael LaCroix-Fralish, Lynn E Macdonald

Neurobiol Pain· June 2023

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IL-6-GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models.
Marisa Carbonaro, Kehui Wang, Hui Huang, Davor Frleta, Aditi Patel, Lynn E Macdonald

Sci Adv· April 2023

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Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model.
A K Patel, Ankur Dhanik, Wei Keat Lim, Christina Adler, Min Ni, Lynn Macdonald

Commun Biol· April 2023

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Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice.
Wen Lin, Varan Singh, Raynel Springer, Gabrielle Choonoo, Namita Gupta, Lynn Macdonald

Commun Biol· April 2023

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MedDRA Labeling Groupings to Improve Safety Communication in Product Labels.
Ilona Große-Michaelis, Scott Proestel, Radhika M Rao, Brian S Dillman, Silvia Bader-Weder, Lynn Macdonald

Ther Innov Regul Sci· January 2023

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Cancer cell-derived type I interferons instruct tumor monocyte polarization.
Dylan Kwart, Jing He, Subhashini Srivatsan, Clarissa Lett, Jacquelynn Golubov, Lynn Macdonald

Cell Rep· December 2022

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Accumulation of high molecular weight kininogen in the brains of Alzheimer's disease patients may affect microglial function by altering phagocytosis and lysosomal cathepsin activity.
Daria Zamolodchikov, Michael Duffield, Lynn E Macdonald, Nicole Alessandri-Haber

Alzheimers Dement· October 2022

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Immuno-PET Monitoring of Lymphocytes Using the CD8-Specific Antibody REGN5054.
Richard Tavaré, Makenzie Danton, Jason T Giurleo, Sosina Makonnen, Carlos Hickey, Lynn E Macdonald

Cancer Immunol Res· October 2022

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IgG Subclass-Dependent Pulmonary Antigen Retention during Acute IgG-Dependent Systemic Anaphylaxis in Mice.
Biliana Todorova, Ophélie Godon, Eva Conde, Caitlin M Gillis, Bruno Iannascoli, Lynn E Macdonald

J Immunol· October 2022

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Disruption of nuclear envelope integrity as a possible initiating event in tauopathies.
Marine Prissette, Wen Fury, Matthew Koss, Claudia Racioppi, Daria Fedorova, Lynn E Macdonald

Cell Rep· August 2022

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A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma.
Nikos Kourtis, Qingqing Wang, Bei Wang, Erin Oswald, Christina Adler, Lynn E Macdonald

Nat Cancer· July 2022

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Humanization of T cell-mediated immunity in mice.
Michael J Moore, Maggie Zhong, Johanna Hansen, Hans Gartner, Craig Grant, Lynn E Macdonald

Sci Immunol· December 2021

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AdRoit is an accurate and robust method to infer complex transcriptome composition.
Tao Yang, Nicole Alessandri-Haber, Wen Fury, Michael Schaner, Robert Breese, Lynn E Macdonald

Commun Biol· October 2021

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A framework for highly multiplexed dextramer mapping and prediction of T cell receptor sequences to antigen specificity.
Wen Zhang, Peter G Hawkins, Jing He, Namita T Gupta, Jinrui Liu, Lynn E Macdonald

Sci Adv· May 2021

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