Publications by authors named "Lynne Howells"

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An old spice with new tricks: Curcumin targets adenoma and colorectal cancer stem-like cells associated with poor survival outcomes.
Sam Khan, Ankur Karmokar, Lynne Howells, Robert G Britton, Emma Parrott, Raquel Palacios-Gallego, Cristina Tufarelli, Hong Cai, Jennifer Higgins, Nicolas Sylvius

October 2025

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Clinical Validation of Local Versus Commercial Genomic Testing in Cancer: A Comparison of Tissue and Plasma Concordance.
Lucy G Faulkner, Lynne Howells, Susann Lehman, Caroline Cowley, Zahirah Sidat

Cancer Invest· February 2025

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Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells.
Saif Sattar Alaqbi, Lynsey Burke, Inna Guterman, Caleb Green, Kevin West, Lynne M Howells

PLoS One· July 2024

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An optimised patient-derived explant platform for breast cancer reflects clinical responses to chemotherapy and antibody-directed therapy.
Constantinos Demetriou, Naila Abid, Michael Butterworth, Larissa Lezina, Pavandeep Sandhu, Lynne Howells

Sci Rep· June 2024

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Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities.
Karen Brown, Despoina Theofanous, Robert G Britton, Grandezza Aburido, Coral Pepper, Lynne Howells

Int J Mol Sci· January 2024

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Clinical trials in cancer screening, prevention and early diagnosis (SPED): a systematic mapping review.
Emma L O'Dowd, Samuel W D Merriel, Vinton W T Cheng, Sam Khan, Lynne M Howells

BMC Cancer· September 2023

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The utility of ctDNA in detecting minimal residual disease following curative surgery in colorectal cancer: a systematic review and meta-analysis.
Lucy G Faulkner, Lynne M Howells, Coral Pepper, Jacqueline A Shaw, Anne L Thomas

Br J Cancer· January 2023

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Ex vivo explant model of adenoma and colorectal cancer to explore mechanisms of action and patient response to cancer prevention therapies.
Sam Khan, Gareth J Miles, Constantinos Demetriou, Zahirah Sidat, Nalini Foreman, Lynne Howells

Mutagenesis· December 2022

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Inequalities in cancer screening, prevention and service engagement between UK ethnic minority groups.
Shalin Abraham, Nalini Foreman, Zahirah Sidat, Pavandeep Sandhu, Domenic Marrone, Lynne M Howells

Br J Nurs· May 2022

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A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps.
Irene Maria Briata, Laura Paleari, Mariangela Rutigliani, Marilena Petrera, Silvia Caviglia, Lynne Howells

Int J Mol Sci· October 2021

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A Systematic Review Assessing Clinical Utility of Curcumin with a Focus on Cancer Prevention.
Lynne Howells, Rushad Malhotra Mukhtyar, Despoina Theofanous, Coral Pepper, Anne Thomas

Mol Nutr Food Res· July 2021

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Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants.
Gareth J Miles, Ian Powley, Seid Mohammed, Lynne Howells, J Howard Pringle

Lab Invest· March 2021

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Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients.
Giuditta Viticchié, Ian Powley, Constantinos Demetriou, James Cooper, Michael Butterworth, Lynne Howells

J Vis Exp· February 2021

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Risk of cancer incidence and mortality associated with diabetes: A systematic review with trend analysis of 203 cohorts.
Suping Ling, Karen Brown, Joanne K Miksza, Lynne M Howells, Amy Morrison

Nutr Metab Cardiovasc Dis· January 2021

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Association of Type 2 Diabetes With Cancer: A Meta-analysis With Bias Analysis for Unmeasured Confounding in 151 Cohorts Comprising 32 Million People.
Suping Ling, Karen Brown, Joanne K Miksza, Lynne Howells, Amy Morrison

Diabetes Care· September 2020

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Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery.
Ian R Powley, Meeta Patel, Gareth Miles, Howard Pringle, Lynne Howells

Br J Cancer· March 2020

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Myeloid derived suppressor cells are reduced and T regulatory cells stabilised in patients with advanced pancreatic cancer treated with gemcitabine and intravenous omega 3.
John Isherwood, Ali Arshad, Wen Yuan Chung, Franscois Runau, Jill Cooke, Lynne Howells

Ann Transl Med· March 2020

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New Paradigms to Assess Consequences of Long-Term, Low-Dose Curcumin Exposure in Lung Cancer Cells.
Gintare Smagurauskaite, Jagdish Mahale, Karen Brown, Anne L Thomas, Lynne M Howells

Molecules· January 2020

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Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial.
Lynne M Howells, Chinenye O O Iwuji, Glen R B Irving, Shaun Barber, Harriet Walter

J Nutr· July 2019

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Detection of Plasma Curcuminoids from Dietary Intake of Turmeric-Containing Food in Human Volunteers.
Jagdish Mahale, Rajinder Singh, Lynne M Howells, Robert G Britton, Sameena M Khan

Mol Nutr Food Res· August 2018

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Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes.
Constantinos Alexandrou, Saif Sattar Al-Aqbi, Jennifer A Higgins, William Boyle, Ankur Karmokar, Lynne M Howells

Sci Rep· August 2018

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Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity.
Ni Ni Moe Myint, Ajay M Verma, Daniel Fernandez-Garcia, Panchali Sarmah, Patrick S Tarpey, Lynne M Howells

Cell Death Dis· August 2018

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An HPLC-UV method for the simultaneous quantification of curcumin and its metabolites in plasma and lung tissue: Potential for preclinical applications.
Jagdish Mahale, Lynne M Howells, Rajinder Singh, Robert G Britton, Hong Cai

Biomed Chromatogr· May 2018

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Effects of Omegaven®, EPA, DHA and oxaliplatin on oesophageal adenocarcinoma cell lines growth, cytokine and cell signal biomarkers expression.
Amar M Eltweri, Lynne M Howells, Anne L Thomas, Ashley R Dennison, David J Bowrey

Lipids Health Dis· January 2018

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Assessing barriers to a rational chemoprevention trial design in young patients with familial adenomatous polyposis.
Joanna P Wood, Lynne M Howells, Karen Brown, Anne L Thomas

Eur J Cancer Prev· July 2017

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