Publications by authors named "Magda Sayed"

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Design and synthesis of sorafenib-inspired benzofuran hybrids as VEGFR-2 inhibitors: antiproliferative evaluation, mechanistic insights, and docking studies in hepatocellular carcinoma.
Mohamed S Shehda, Aya M Almatary, Mohamed S H Salem, Mohamed H Aboutaleb, Shinobu Takizawa, Magda A A El-Sayed

RSC Med Chem· December 2025

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Dialkyloxyphenyl hybrids as PDE4B inhibitors: Design, synthesis, in vitro/in vivo anti-inflammatory activity and in silico insights.
Aya M Almatary, Mohamed S H Salem, Mohamed R Elnagar, Mohamed H Aboutaleb, Tarek S Ibrahim, Magda A-A El-Sayed

Bioorg Chem· July 2025

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Development of 1,2,3-triazole hybrids as multi-faced anticancer agents co-targeting EGFR/mTOR pathway and tubulin depolymerization.
Mennatallah A Shaheen, Khaled M Darwish, Safaa M Kishk, Magda A-A El-Sayed, Ismail Salama

Bioorg Chem· March 2025

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Exploring 1,2,3-triazole-Schiff's base hybrids as innovative EGFR inhibitors for the treatment of breast cancer: In vitro and in silico study.
Nareman A Nawareg, Asmaa S A Yassen, Ebtehal M Husseiny, Magda A A El-Sayed, Hosam A Elshihawy

Bioorg Chem· February 2025

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Design, synthesis and computational study of new benzofuran hybrids as dual PI3K/VEGFR2 inhibitors targeting cancer.
Omar A El-Khouly, Morkos A Henen, Magda A-A El-Sayed, Shahenda M El-Messery

Sci Rep· October 2022

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In vitro cytotoxicity and docking study of novel symmetric and asymmetric dihydropyridines and pyridines as EGFR tyrosine kinase inhibitors.
Basem Mansour, Waleed A Bayoumi, Magda A El-Sayed, Laila A Abouzeid, Mohammed A M Massoud

Chem Biol Drug Des· July 2022

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Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and molecular modelling study.
Salma Fares, Khalid B Selim, Fatma E Goda, Magda A A El-Sayed, Nawaf A AlSaif

J Enzyme Inhib Med Chem· December 2021

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Synthesis, anticancer and antimicrobial evaluation of new benzofuran based derivatives: PI3K inhibition, quorum sensing and molecular modeling study.
Omar A El-Khouly, Morkos A Henen, Magda A-A El-Sayed, Mona I Shabaan, Shahenda M El-Messery

Bioorg Med Chem· February 2021

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Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition.
Walaa M El-Husseiny, Magda A-A El-Sayed, Adel S El-Azab, Nawaf A AlSaif, Mohammed M Alanazi

J Enzyme Inhib Med Chem· December 2020

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1,2,3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226.
Heba F Ashour, Laila A Abou-Zeid, Magda A-A El-Sayed, Khalid B Selim

Eur J Med Chem· March 2020

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Design, Synthesis and Anticancer Evaluation of New Substituted Thiophene-Quinoline Derivatives.
Dina I A Othman, Khalid B Selim, Magda A-A El-Sayed, Atif S Tantawy, Yhiya Amen

Bioorg Med Chem· October 2019

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Design, synthesis, and docking study of new quinoline derivatives as antitumor agents.
Eman E Nasr, Amany S Mostafa, Magda A A El-Sayed, Mohammed A M Massoud

Arch Pharm (Weinheim)· July 2019

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Design, synthesis and docking study of novel picolinamide derivatives as anticancer agents and VEGFR-2 inhibitors.
Mohamed A Zeidan, Amany S Mostafa, Rania M Gomaa, Laila A Abou-Zeid, Mohamed El-Mesery, Magda A-A El-Sayed

Eur J Med Chem· April 2019

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Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study.
Magda A-A El-Sayed, Walaa M El-Husseiny, Naglaa I Abdel-Aziz, Adel S El-Azab, Hatem A Abuelizz

J Enzyme Inhib Med Chem· December 2018

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Synthesis, antitumour and antioxidant activities of novel α,β-unsaturated ketones and related heterocyclic analogues: EGFR inhibition and molecular modelling study.
Walaa M El-Husseiny, Magda A-A El-Sayed, Naglaa I Abdel-Aziz, Adel S El-Azab, Esam R Ahmed

J Enzyme Inhib Med Chem· December 2018

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Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies.
Adel S El-Azab, Alaa A-M Abdel-Aziz, Laila A Abou-Zeid, Walaa M El-Husseiny, Ahmad M El Morsy, Magda A-A El-Sayed

J Enzyme Inhib Med Chem· December 2018

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Structural alterations based on naproxen scaffold: Synthesis, evaluation of antitumor activity and COX-2 inhibition, and molecular docking.
Walaa M El-Husseiny, Magda A-A El-Sayed, Naglaa I Abdel-Aziz, Adel S El-Azab, Yousif A Asiri

Eur J Med Chem· October 2018

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Design, synthesis, and molecular modeling of heterocyclic bioisostere as potent PDE4 inhibitors.
Aya M Almatary, Mohammad A Elmorsy, Walaa M El Husseiny, Khalid B Selim, Magda A-A El-Sayed

Arch Pharm (Weinheim)· April 2018

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Synthesis, antitumor activity and molecular docking study of some novel 3-benzyl-4(3H)quinazolinone analogues.
Ibrahim A Al-Suwaidan, Alaa A-M Abdel-Aziz, Taghreed Z Shawer, Rezk R Ayyad, Amer M Alanazi, Magda A-A El-Sayed

J Enzyme Inhib Med Chem· October 2016

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Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones.
Alaa A-M Abdel-Aziz, Laila A Abou-Zeid, Kamal Eldin H ElTahir, Rezk R Ayyad, Magda A-A El-Sayed

Eur J Med Chem· October 2016

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Antitumor evaluation and molecular docking study of substituted 2-benzylidenebutane-1,3-dione, 2-hydrazonobutane-1,3-dione and trifluoromethyl-1H-pyrazole analogues.
Ibrahim A Al-Suwaidan, Naglaa I Abdel-Aziz, Adel S El-Azab, Magda A-A El-Sayed, Amer M Alanazi

J Enzyme Inhib Med Chem· April 2016

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Synthesis and biological evaluation of new curcumin analogues as antioxidant and antitumor agents: molecular modeling study.
Said M Bayomi, Hassan A El-Kashef, Mahmoud B El-Ashmawy, Magda N A Nasr, Magda A El-Sherbeny, Magda A-A El-Sayed

Eur J Med Chem· August 2015

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Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.
Magda A-A El-Sayed, Naglaa I Abdel-Aziz, Alaa A-M Abdel-Aziz, Adel S El-Azab, Kamal E H ElTahir

Bioorg Med Chem· May 2012

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Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.
Magda A-A El-Sayed, Naglaa I Abdel-Aziz, Alaa A-M Abdel-Aziz, Adel S El-Azab, Yousif A Asiri

Bioorg Med Chem· June 2011

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Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: molecular docking study.
Adel S El-Azab, Mohamed A Al-Omar, Alaa A-M Abdel-Aziz, Naglaa I Abdel-Aziz, Magda A-A el-Sayed, Mohamed M Sayed-Ahmed

Eur J Med Chem· September 2010

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