Publications by authors named "Mark Kleinman"

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Deciphering age-related transcriptomic changes in the mouse retinal pigment epithelium.
Sushil K Dubey, Rashmi Dubey, Kyungsik Jung, Alvaro G Hernandez, Mark E Kleinman

Aging (Albany NY)· March 2025

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Histone deficiency and hypoacetylation in the aging retinal pigment epithelium.
Sushil K Dubey, Rashmi Dubey, Subhash C Prajapati, Kyungsik Jung, Kabhilan Mohan, Mark E Kleinman

Aging Cell· May 2024

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Unraveling Histone Loss in Aging and Senescence.
Sushil Kumar Dubey, Rashmi Dubey, Mark Ellsworth Kleinman

Cells· February 2024

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Long-Term Evaluation of Retinal Morphology and Function in Rosa26-Cas9 Knock-In Mice.
Kabhilan Mohan, Sushil Kumar Dubey, Kyungsik Jung, Rashmi Dubey, Qing Jun Wang, Mark Ellsworth Kleinman

Int J Mol Sci· March 2023

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Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration.
Gopalan Gnanaguru, Alexandre Wagschal, Justin Oh, Kahira L Saez-Torres, Tong Li, Mark E Kleinman

Mol Ther· July 2021

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Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium.
Yu Zhong, Kabhilan Mohan, Jinpeng Liu, Ahmad Al-Attar, Penghui Lin, Mark E Kleinman

Biochim Biophys Acta Mol Basis Dis· October 2020

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Imaging data on characterization of retinal autofluorescent lesions in a mouse model of juvenile neuronal ceroid lipofuscinosis (CLN3 disease).
Qing Jun Wang, Kyung Sik Jung, Kabhilan Mohan, Mark E Kleinman

Data Brief· October 2020

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Complement Activation and Inhibition in Retinal Diseases.
Mark E Kleinman, Jayakrishna Ambati

Dev Ophthalmol· June 2016

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Vision loss in juvenile neuronal ceroid lipofuscinosis (CLN3 disease).
Madhu M Ouseph, Mark E Kleinman, Qing Jun Wang

Ann N Y Acad Sci· May 2016

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Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration.
Andre K Berner, Mark E Kleinman

Adv Exp Med Biol· April 2016

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Implications of In-Use Photostability: Proposed Guidance for Photostability Testing and Labeling to Support the Administration of Photosensitive Pharmaceutical Products, Part 2: Topical Drug Product.
Steven W Baertschi, David Clapham, Chris Foti, Mark H Kleinman, Solveig Kristensen

J Pharm Sci· September 2015

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Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome.
Bradley D Gelfand, Charles B Wright, Younghee Kim, Tetsuhiro Yasuma, Reo Yasuma, Mark E Kleinman

Cell Rep· June 2015

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In silico prediction of pharmaceutical degradation pathways: a benchmarking study.
Mark H Kleinman, Steven W Baertschi, Karen M Alsante, Darren L Reid, Mark D Mowery

Mol Pharm· November 2014

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The Immune System and AMD.
Paul A Frederick, Mark E Kleinman

Curr Ophthalmol Rep· March 2014

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Standardized UV-vis spectra as the foundation for a threshold-based, integrated photosafety evaluation.
Daniel Bauer, Lacey A Averett, Ann De Smedt, Mark H Kleinman, Wolfgang Muster

Regul Toxicol Pharmacol· February 2014

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Recent trends in product development and regulatory issues on impurities in active pharmaceutical ingredient (API) and drug products. Part 1: Predicting degradation related impurities and impurity considerations for pharmaceutical dosage forms.
Karen M Alsante, Kim Huynh-Ba, Steven W Baertschi, Robert A Reed, Margaret S Landis, Mark H Kleinman

AAPS PharmSciTech· February 2014

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Clocking in on diabetic retinopathy.
Mark E Kleinman, Jayakrishna Ambati

Diabetes· January 2013

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ERK1/2 activation is a therapeutic target in age-related macular degeneration.
Sami Dridi, Yoshio Hirano, Valeria Tarallo, Younghee Kim, Benjamin J Fowler, Mark E Kleinman

Proc Natl Acad Sci U S A· August 2012

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DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.
Valeria Tarallo, Yoshio Hirano, Bradley D Gelfand, Sami Dridi, Nagaraj Kerur, Mark E Kleinman

Cell· May 2012

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A window to innate neuroimmunity: Toll-like receptor-mediated cell responses in the retina.
Mark E Kleinman, Jayakrishna Ambati

Adv Exp Med Biol· April 2012

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The use of N-methylpyrrolidone as a cosolvent and oxidant in pharmaceutical stress testing.
Dan W Reynolds, Marina Galvani, Simon R Hicks, Biren J Joshi, Sonya A Kennedy-Gabb, Mark H Kleinman

J Pharm Sci· February 2012

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Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3.
Mark E Kleinman, Hiroki Kaneko, Won Gil Cho, Sami Dridi, Benjamin J Fowler

Mol Ther· January 2012

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DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.
Hiroki Kaneko, Sami Dridi, Valeria Tarallo, Bradley D Gelfand, Benjamin J Fowler, Mark E Kleinman

Nature· March 2011

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The multifactorial nature of retinal vascular disease.
Mark E Kleinman, Judit Z Baffi, Jayakrishna Ambati

Ophthalmologica· January 2011

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Triamcinolone crystal size.
Mark E Kleinman, Scott J Westhouse, Jayakrishna Ambati, P Andrew Pearson, Lawrence S Halperin

Ophthalmology· August 2010

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