Publications by authors named "Matthew D Shoulders"

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Collagen structure and stability.
Matthew D Shoulders, Ronald T Raines

July 2009

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Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells.
Andrew L Sabol, Amanuella A Mengiste, Vedagopuram Sreekanth, Prashant Singh, Samuel J Hendel, Matthew D Shoulders

bioRxiv· December 2025

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Failed cellular surveillance enables pathogenic matrix deposition in a COL2A1-related osteoarthritis.
Kathryn M Yammine, Sophia Mirda Abularach, Michael Xiong, Seo-Yeon Kim, Agata A Bikovtseva, Matthew D Shoulders

J Biol Chem· August 2025

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In vivo directed evolution of an ultrafast Rubisco from a semianaerobic environment imparts oxygen resistance.
Julie L McDonald, Nathan P Shapiro, Amanuella A Mengiste, Sarah Kaines, Spencer M Whitney, Matthew D Shoulders

Proc Natl Acad Sci U S A· July 2025

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Failed Cellular Surveillance Enables Pathogenic Matrix Deposition in a -Related Osteoarthritis.
Kathryn M Yammine, Sophia Mirda Abularach, Michael Xiong, Seo-Yeon Kim, Agata A Bikovtseva, Matthew D Shoulders

bioRxiv· June 2025

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Failed Cellular Surveillance Enables Pathogenic Matrix Deposition in a -Related Osteoarthritis.
Kathryn M Yammine, Sophia Mirda Abularach, Michael Xiong, Seo-Yeon Kim, Agata A Bikovtseva, Matthew D Shoulders

bioRxiv· June 2025

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Directed Evolution of an Ultra-Fast Rubisco from a Semi-Anaerobic Environment Imparts Oxygen Resistance.
Julie L McDonald, Nathan P Shapiro, Amanuella A Mengiste, Sarah Kaines, Spencer M Whitney, Matthew D Shoulders

bioRxiv· May 2025

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Protein Glycosylation Patterns Shaped By the IRE1-XBP1s Arm of the Unfolded Protein Response.
Kenny Chen, Matthew D Shoulders

Isr J Chem· December 2024

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Endoplasmic Reticulum Oxidative Stress Promotes Glutathione-Dependent Oxidation of Collagen-1A1 and Promotes Lung Fibroblast Activation.
Joseph E Druso, Maximilian B MacPherson, Shi B Chia, Evan Elko, Reem Aboushousha, Matthew D Shoulders

Am J Respir Cell Mol Biol· November 2024

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An outcome-defining role for the triple-helical domain in regulating collagen-I assembly.
Kathryn M Yammine, Rasia C Li, Isabella M Borgula, Sophia Mirda Abularach, Andrew S DiChiara, Matthew D Shoulders

Proc Natl Acad Sci U S A· November 2024

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Dominant-negative mutations potentiated by the HSF1-regulated proteostasis network.
Rebecca M Sebastian, Jessica E Patrick, Tiffani Hui, David R Amici, Andrew O Giacomelli, Matthew D Shoulders

bioRxiv· November 2024

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ER procollagen storage defect without coupled unfolded protein response drives precocious arthritis.
Kathryn M Yammine, Sophia Mirda Abularach, Seo-Yeon Kim, Agata A Bikovtseva, Jinia Lilianty, Matthew D Shoulders

Life Sci Alliance· September 2024

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MutaT7: A Single Chimera for the Targeted, Balanced, Efficient, and Processive Installation of All Possible Transition Mutations .
Amanuella A Mengiste, Julie L McDonald, Minh Thuan Nguyen Tran, Anna V Plank, Robert H Wilson, Matthew D Shoulders

ACS Synth Biol· September 2024

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Evolutionary druggability for low-dimensional fitness landscapes toward new metrics for antimicrobial applications.
Rafael F Guerrero, Tandin Dorji, Ra'Mal M Harris, Matthew D Shoulders, C Brandon Ogbunugafor

Elife· June 2024

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The immune-evasive proline-283 substitution in influenza nucleoprotein increases aggregation propensity without altering the native structure.
Jimin Yoon, Yu Meng Zhang, Cheenou Her, Robert A Grant, Anna I Ponomarenko, Matthew D Shoulders

Sci Adv· April 2024

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Epistasis and pleiotropy shape biophysical protein subspaces associated with drug resistance.
C Brandon Ogbunugafor, Rafael F Guerrero, Miles D Miller-Dickson, Eugene I Shakhnovich, Matthew D Shoulders

Phys Rev E· November 2023

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Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications.
Rafael F Guerrero, Tandin Dorji, Ra'Mal M Harris, Matthew D Shoulders, C Brandon Ogbunugafor

bioRxiv· September 2023

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Viral Evolution Shaped by Host Proteostasis Networks.
Jimin Yoon, Jessica E Patrick, C Brandon Ogbunugafor, Matthew D Shoulders

Annu Rev Virol· September 2023

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The Immune-Evasive Proline 283 Substitution in Influenza Nucleoprotein Increases Aggregation Propensity Without Altering the Native Structure.
Jimin Yoon, Yu Meng Zhang, Cheenou Her, Robert A Grant, Anna M Ponomarenko, Matthew D Shoulders

bioRxiv· September 2023

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Expanded MutaT7 toolkit efficiently and simultaneously accesses all possible transition mutations in bacteria.
Amanuella A Mengiste, Robert H Wilson, Rachel F Weissman, Louis J Papa Iii, Samuel J Hendel, Matthew D Shoulders

Nucleic Acids Res· April 2023

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Epistasis meets pleiotropy in shaping biophysical protein subspaces associated with antimicrobial resistance.
C Brandon Ogbunugafor, Rafael F Guerrero, Eugene I Shakhnovich, Matthew D Shoulders

bioRxiv· April 2023

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Using CRISPR/Cas9 to generate a heterozygous COL2A1 p.R719C iPSC line (MCRIi019-A-6) model of human precocious osteoarthritis.
Kathryn M Yammine, Sophia Mirda Abularach, Lisa Sampurno, John F Bateman, Shireen R Lamandé, Matthew D Shoulders

Stem Cell Res· March 2023

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Loss of heat shock factor 1 promotes hepatic stellate cell activation and drives liver fibrosis.
Asmita Choudhury, Anuradha Ratna, Arlene Lim, Rebecca M Sebastian, Christopher L Moore, Matthew D Shoulders

Hepatol Commun· October 2022

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Collagen misfolding mutations: the contribution of the unfolded protein response to the molecular pathology.
John F Bateman, Matthew D Shoulders, Shireen R Lamandé

Connect Tissue Res· May 2022

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Thermal Proteome Profiling Reveals the O-GlcNAc-Dependent Meltome.
Dustin T King, Jesús E Serrano-Negrón, Yanping Zhu, Christopher L Moore, Matthew D Shoulders

J Am Chem Soc· March 2022

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The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope.
Jimin Yoon, Emmanuel E Nekongo, Jessica E Patrick, Tiffani Hui, Angela M Phillips, Matthew D Shoulders

PLoS Biol· February 2022

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