Publications by authors named "Michael A Walters"

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The Essential Medicinal Chemistry of Curcumin.
Kathryn M Nelson, Jayme L Dahlin, Jonathan Bisson, James Graham, Guido F Pauli, Michael A Walters

March 2017

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Development of potent glutathione transferase Omega-1 inhibitors with applications in inflammation and cancer therapy.
Yiyue Xie, Yuji Nakano, Padmaja Tummala, Aaron J Oakley, Adi Suwandi, Michael A Walters

Eur J Med Chem· December 2025

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Reactivation of Oxidized Soluble Guanylate Cyclase as a Novel Treatment Strategy to Slow Progression of Calcific Aortic Valve Stenosis: Preclinical and Randomized Clinical Trials to Assess Safety and Efficacy.
Bin Zhang, Maurice Enriquez-Sarano, Hartzell V Schaff, Hector I Michelena, Carolyn M Roos, Michael A Walters

Circulation· April 2025

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Reengineering of Circularly Permuted Caspase-2 to Enhance Enzyme Stability and Enable Crystallographic Studies.
Jessica L Fuller, Ke Shi, Steffen Pockes, Barry C Finzel, Karen H Ashe, Michael A Walters

ACS Chem Biol· April 2025

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Discovery of a CK2α'-Biased ATP-Competitive Inhibitor from a High-Throughput Screen of an Allosteric-Inhibitor-Like Compound Library.
Deepti Mudaliar, Rachel H Mansky, Angel White, Grace Baudhuin, Jon Hawkinson, Michael A Walters

ACS Chem Neurosci· August 2024

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Development of Allosteric Small Molecule APOBEC3B Inhibitors from Screening.
Katherine F M Jones, Özlem Demir, Mackenzie K Wyllie, Michael J Grillo, Clare Morris, Michael A Walters

bioRxiv· April 2024

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Identification of CK2α' selective inhibitors by the screening of an allosteric-kinase-inhibitor-like compound library.
Deepti Mudaliar, Rachel H Mansky, Angel White, Grace Baudhuin, Jon Hawkinson, Michael A Walters

bioRxiv· January 2024

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An electrophilic fragment screening for the development of small molecules targeting caspase-2.
Matthew E Cuellar, Mu Yang, Surendra Karavadhi, Ya-Qin Zhang, Hu Zhu, Michael A Walters

Eur J Med Chem· November 2023

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Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias.
Steffen Pockes, Michael A Walters, Karen H Ashe

Transl Res· April 2023

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Reference compounds for characterizing cellular injury in high-content cellular morphology assays.
Jayme L Dahlin, Bruce K Hua, Beth E Zucconi, Shawn D Nelson, Shantanu Singh, Michael A Walters

Nat Commun· March 2023

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Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis.
Merlin Bresinsky, Jessica M Strasser, Alexander Hubmann, Bernadette Vallaster, William M McCue, Michael A Walters

Arch Pharm (Weinheim)· September 2022

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Threonine Cavities Are Targetable Motifs That Control Alpha-Synuclein Fibril Growth.
Noah Nathan Kochen, Vivek Vasandani, Darren Seaney, Anil K Pandey, Michael A Walters

ACS Chem Neurosci· September 2022

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Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy.
Gurpreet Singh, Peng Liu, Katherine R Yao, Jessica M Strasser, Chris Hlynialuk, Michael A Walters

ACS Chem Neurosci· May 2022

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Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.
Merlin Bresinsky, Jessica M Strasser, Bernadette Vallaster, Peng Liu, William M McCue, Michael A Walters

ACS Pharmacol Transl Sci· January 2022

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The Communication of Hit Quality Using Natural History Visualizations (NHVs).
Kathryn M Nelson, Michael A Walters

SLAS Discov· August 2021

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Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation.
Jonathan H Shrimp, Yihang Jing, Supuni Thalalla Gamage, Kathryn M Nelson, Joseph Han, Michael A Walters

ACS Med Chem Lett· June 2021

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Nuisance compounds in cellular assays.
Jayme L Dahlin, Douglas S Auld, Ina Rothenaigner, Steve Haney, Jonathan Z Sexton, Michael A Walters

Cell Chem Biol· March 2021

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Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity.
Paul A Jackson, Henry A M Schares, Katherine F M Jones, John C Widen, Daniel P Dempe, Michael A Walters

J Med Chem· December 2020

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The Essential Medicinal Chemistry of Cannabidiol (CBD).
Kathryn M Nelson, Jonathan Bisson, Gurpreet Singh, James G Graham, Shao-Nong Chen, Michael A Walters

J Med Chem· November 2020

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Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α.
James N Ingle, Junmei Cairns, Vera J Suman, Lois E Shepherd, Peter A Fasching, Michael A Walters

Clin Cancer Res· June 2020

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Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
Daniel L Priebbenow, David J Leaver, Nghi Nguyen, Benjamin Cleary, H Rachel Lagiakos, Michael A Walters

J Med Chem· May 2020

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Diversity-Oriented Library Synthesis from Steviol and Isosteviol-Derived Scaffolds.
Trinh A D Holth, Michael A Walters, Oliver E Hutt, Gunda I Georg

ACS Comb Sci· March 2020

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Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors.
Yiyue Xie, Padmaja Tummala, Aaron J Oakley, Girdhar Singh Deora, Yuji Nakano, Michael A Walters

J Med Chem· March 2020

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Improving natural product research translation: From source to clinical trial.
Barbara C Sorkin, Adam J Kuszak, Gregory Bloss, Naomi K Fukagawa, Freddie Ann Hoffman, Michael A Walters

FASEB J· January 2020

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Author Correction: Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system.
Karthik Selvaraju, Arjan Mofers, Paola Pellegrini, Johannes Salomonsson, Alexandra Ahlner, Michael A Walters

Sci Rep· November 2019

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A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death.
Darko Bosnakovski, Meiricris T da Silva, Sithara T Sunny, Elizabeth T Ener, Erik A Toso, Michael A Walters

Sci Adv· September 2019

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