Publications by authors named "Michael Ansonoff"

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7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects.
Andrew C Kruegel, Rajendra Uprety, Steven G Grinnell, Cory Langreck, Elizabeth A Pekarskaya, Valerie Le Rouzic, Michael Ansonoff, Madalee M Gassaway, John E Pintar, Gavril W Pasternak

June 2019

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Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic.
Balazs R Varga, Rajendra Uprety, Barnali Paul, Alexis Knoll, Nokomis Ramos-Gonzalez, Michael Ansonoff

ACS Chem Neurosci· July 2025

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Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models.
Václav Havel, Andrew C Kruegel, Benjamin Bechand, Scot McIntosh, Leia Stallings, Michael Ansonoff

Nat Commun· September 2024

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Oxidative Metabolism as a Modulator of Kratom's Biological Actions.
Soumen Chakraborty, Rajendra Uprety, Samuel T Slocum, Takeshi Irie, Valerie Le Rouzic, Michael Ansonoff

J Med Chem· November 2021

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FBNTI, a DOR-Selective Antagonist That Allosterically Activates MOR within a MOR-DOR Heteromer.
Eyup Akgün, Mary M Lunzer, Defeng Tian, Michael Ansonoff, John Pintar

Biochemistry· May 2021

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Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template.
Abdelfattah Faouzi, Rajendra Uprety, Ivone Gomes, Nicolas Massaly, Attila I Keresztes, Michael Ansonoff

J Med Chem· November 2020

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The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor.
Benjamin Adam Samuels, Katherine M Nautiyal, Andrew C Kruegel, Marjorie R Levinstein, Valerie M Magalong, Michael A Ansonoff

Neuropsychopharmacology· September 2017

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Opioids and opioid receptors orchestrate wound repair.
Ying Wang, Mihir Gupta, Tasneem Poonawala, Mariya Farooqui, Yunfang Li, Michael Ansonoff

Transl Res· July 2017

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Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors.
Jeffrey M Witkin, Linda M Rorick-Kehn, Mark J Benvenga, Benjamin L Adams, Scott D Gleason, Michael A Ansonoff

Pharmacol Res Perspect· December 2016

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Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants.
Steven G Grinnell, Michael Ansonoff, Gina F Marrone, Zhigang Lu, Ankita Narayan

Synapse· October 2016

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A Novel Nociceptin Receptor Antagonist LY2940094 Inhibits Excessive Feeding Behavior in Rodents: A Possible Mechanism for the Treatment of Binge Eating Disorder.
Michael A Statnick, Yanyun Chen, Michael Ansonoff, Jeffrey M Witkin, Linda Rorick-Kehn

J Pharmacol Exp Ther· February 2016

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Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA.
Steven G Grinnell, Susruta Majumdar, Ankita Narayan, Valerie Le Rouzic, Michael Ansonoff

J Pharmacol Exp Ther· September 2014

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The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence.
Jeffrey M Witkin, Michael A Statnick, Linda M Rorick-Kehn, John E Pintar, Michael Ansonoff

Pharmacol Ther· March 2014

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Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects.
Susruta Majumdar, Steven Grinnell, Valerie Le Rouzic, Maxim Burgman, Lisa Polikar, Michael Ansonoff

Proc Natl Acad Sci U S A· December 2011

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Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands.
Michael A Ansonoff, Philip S Portoghese, John E Pintar

Psychopharmacology (Berl)· June 2010

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Kappa2 opioid receptor subtype binding requires the presence of the DOR-1 gene.
Michael A Ansonoff, Ting Wen, John E Pintar

Front Biosci (Schol Ed)· January 2010

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The tail pigmentation pattern of C57BL/6J mice affects nociception/pain quantification in the tail flick test.
Ting Wen, Michael A Ansonoff, John E Pintar

Eur J Pain· July 2009

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Nociceptin/orphanin FQ (N/OFQ)-evoked bradycardia, hypotension, and diuresis are absent in N/OFQ peptide (NOP) receptor knockout mice.
Melissa A Burmeister, Michael A Ansonoff, John E Pintar, Daniel R Kapusta

J Pharmacol Exp Ther· September 2008

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Morphine induces mesangial cell proliferation and glomerulopathy via kappa-opioid receptors.
Marc L Weber, Mariya Farooqui, Julia Nguyen, Michael Ansonoff, John E Pintar

Am J Physiol Renal Physiol· June 2008

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Codeine and 6-acetylcodeine analgesia in mice.
Steven Milo, Michael Ansonoff, Michael King, Grace C Rossi, Amy Zuckerman

Cell Mol Neurobiol· April 2007

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Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice.
Michael A Ansonoff, Jiwen Zhang, Traci Czyzyk, Richard B Rothman, Jeremy Stewart

J Pharmacol Exp Ther· August 2006

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Differential sensitivities of mouse strains to morphine and [Dmt1]DALDA analgesia.
Claire L Neilan, Michael A King, Grace Rossi, Michael Ansonoff, John E Pintar

Brain Res· June 2003

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