Publications by authors named "Michelle McClements"

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Gene Therapy Strategies for the Treatment of Bestrophinopathies.
Silja B Haldrup, Michelle E McClements, Jasmina Cehajic-Kapetanovic, Thomas J Corydon, Robert E MacLaren

Int J Mol Sci· September 2025

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CRISPR targeting of SNPs associated with age-related macular degeneration in ARPE-19 cells: a potential model for manipulating the complement system.
Ahmed Salman, Won Kyung Song, Tina Storm, Michelle E McClements, Robert E MacLaren

Gene Ther· March 2025

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Comparison of CRISPR-Cas13b RNA base editing approaches for USH2A-associated inherited retinal degeneration.
Lewis E Fry, Lauren Major, Ahmed Salman, Lucy A McDermott, Jun Yang, Michelle E McClements

Commun Biol· February 2025

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Gene Therapies in Clinical Development to Treat Retinal Disorders.
Michelle E McClements, Maram E A Abdalla Elsayed, Lauren Major, Cristina Martinez-Fernandez de la Camara, Robert E MacLaren

Mol Diagn Ther· September 2024

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Genetic therapies and potential therapeutic applications of CRISPR activators in the eye.
Benjamin Wj Ng, Maria K Kaukonen, Michelle E McClements, Hoda Shamsnajafabadi, Robert E MacLaren

Prog Retin Eye Res· September 2024

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Single-cell transcriptomic analysis of retinal immune regulation and blood-retinal barrier function during experimental autoimmune uveitis.
Joel Quinn, Ahmed Salman, Christopher Paluch, Matthew Jackson-Wood, Michelle E McClements

Sci Rep· August 2024

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Rescue of cone and rod photoreceptor function in a CDHR1-model of age-related retinal degeneration.
Imran H Yusuf, Thomas Burgoyne, Ahmed Salman, Michelle E McClements, Robert E MacLaren

Mol Ther· May 2024

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CRISPR Manipulation of Age-Related Macular Degeneration Haplotypes in the Complement System: Potential Future Therapeutic Applications/Avenues.
Ahmed Salman, Michelle E McClements, Robert E MacLaren

Int J Mol Sci· January 2024

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Programmable RNA editing with endogenous ADAR enzymes - a feasible option for the treatment of inherited retinal disease?
Julia-Sophia Bellingrath, Michelle E McClements, M Dominik Fischer, Robert E MacLaren

Front Mol Neurosci· May 2023

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A Review of CRISPR Tools for Treating Usher Syndrome: Applicability, Safety, Efficiency, and In Vivo Delivery.
Lauren Major, Michelle E McClements, Robert E MacLaren

Int J Mol Sci· April 2023

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Erratum: Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues.
Laurel C Chandler, Alun R Barnard, Sarah L Caddy, Maria I Patrício, Michelle E McClements

Mol Ther Methods Clin Dev· March 2023

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Future Perspectives of Prime Editing for the Treatment of Inherited Retinal Diseases.
Silja Hansen, Michelle E McClements, Thomas J Corydon, Robert E MacLaren

Cells· January 2023

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Impaired glutamylation of RPGR underlies the cone-dominated phenotype associated with truncating distal ORF15 variants.
Jasmina Cehajic-Kapetanovic, Cristina Martinez-Fernandez de la Camara, Johannes Birtel, Salwah Rehman, Michelle E McClements

Proc Natl Acad Sci U S A· December 2022

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New CRISPR Tools to Correct Pathogenic Mutations in Usher Syndrome.
Lauren Major, Michelle E McClements, Robert E MacLaren

Int J Mol Sci· October 2022

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Minicircle Delivery to the Neural Retina as a Gene Therapy Approach.
Federica Staurenghi, Michelle E McClements, Ahmed Salman, Robert E MacLaren

Int J Mol Sci· October 2022

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Non-Viral Delivery of CRISPR/Cas Cargo to the Retina Using Nanoparticles: Current Possibilities, Challenges, and Limitations.
Ahmed Salman, Ariel Kantor, Michelle E McClements, Gemma Marfany, Sonia Trigueros

Pharmaceutics· September 2022

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CRISPR DNA Base Editing Strategies for Treating Retinitis Pigmentosa Caused by Mutations in .
Maria Kaukonen, Michelle E McClements, Robert E MacLaren

Genes (Basel)· July 2022

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AAV2-mediated gene therapy for Bietti crystalline dystrophy provides functional CYP4V2 in multiple relevant cell models.
Jiang-Hui Wang, Grace E Lidgerwood, Maciej Daniszewski, Monica L Hu, Georgina E Roberts, Michelle E McClements

Sci Rep· June 2022

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CRISPR Systems Suitable for Single AAV Vector Delivery.
Marta Stevanovic, Elena Piotter, Michelle E McClements, Robert E MacLaren

Curr Gene Ther· April 2022

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Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids.
Michelle E McClements, Hannah Steward, William Atkin, Emily Archer Goode, Carolina Gándara

Transl Vis Sci Technol· April 2022

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The Scope of Pathogenic ABCA4 Mutations Targetable by CRISPR DNA Base Editing Systems-A Systematic Review.
Elena Piotter, Michelle E McClements, Robert E MacLaren

Front Genet· January 2022

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In Silico Analysis of Pathogenic Single Nucleotide Variants and Their Amenability to Base Editing as a Potential Lead for Therapeutic Intervention.
Julia-Sophia Bellingrath, Michelle E McClements, Maria Kaukonen, Manuel Dominik Fischer, Robert E MacLaren

Genes (Basel)· November 2021

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Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina.
Laurel C Chandler, Michelle E McClements, Imran H Yusuf, Cristina Martinez-Fernandez de la Camara, Robert E MacLaren

Mol Ther Methods Clin Dev· September 2021

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Therapy Approaches for Stargardt Disease.
Elena Piotter, Michelle E McClements, Robert E MacLaren

Biomolecules· August 2021

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Insights on the Regeneration Potential of Müller Glia in the Mammalian Retina.
Ahmed Salman, Michelle E McClements, Robert E MacLaren

Cells· July 2021

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