Publications by authors named "Nicholas Hum"

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Early immune response to is characterized by robust neutrophil and fibrotic macrophage recruitment and differentiation.
Nadia Miranda, Oscar A Davalos, Aimy Sebastian, Margarita V Rangel, Nicole F Leon, Nicholas R Hum

Microbiol Spectr· September 2025

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Single cell RNA sequencing reveals shifts in cell maturity and function of endogenous and infiltrating cell types in response to acute intervertebral disc injury.
Sade W Clayton, Aimy Sebastian, Stephen P Wilson, Nicholas R Hum, Remy E Walk

Exp Cell Res· August 2025

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Spatiotemporal analysis of lung immune dynamics in lethal infection.
Oscar A Davalos, Aimy Sebastian, Nicole F Leon, Margarita V Rangel, Nadia Miranda, Nicholas R Hum

mBio· May 2025

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Osteocytic oxygen sensing: Distinct impacts of VHL and HIF-2alpha on bone integrity.
Sarah V Mendoza, Kristina V Wells, Deepa K Murugesh, Nicholas R Hum, Aimy Sebastian

Bone· March 2025

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Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures.
Noah Goshi, Doris Lam, Chandrakumar Bogguri, Vivek Kurien George, Aimy Sebastian, Nicholas R Hum

Front Cell Neurosci· February 2025

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Single cell RNA sequencing reveals shifts in cell maturity and function of endogenous and infiltrating cell types in response to acute intervertebral disc injury.
Sade W Clayton, Aimy Sebastian, Stephen P Wilson, Nicholas R Hum, Remy E Walk

bioRxiv· January 2025

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Single-cell and spatiotemporal transcriptomic profiling of brain immune infiltration following Venezuelan equine encephalitis virus infection.
Margarita V Rangel, Aimy Sebastian, Nicole F Leon, Ashlee M Phillips, Bria M Gorman, Nicholas R Hum

Front Immunol· January 2025

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CD206+ Trem2+ macrophage accumulation in the murine knee joint after injury is associated with protection against post-traumatic osteoarthritis in MRL/MpJ mice.
Jillian L McCool, Aimy Sebastian, Nicholas R Hum, Stephen P Wilson, Oscar A Davalos

PLoS One· January 2025

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Biphasic response of human iPSC-derived neural network activity following exposure to a sarin-surrogate nerve agent.
Chandrakumar Bogguri, Vivek Kurien George, Beheshta Amiri, Alexander Ladd, Nicholas R Hum

Front Cell Neurosci· September 2024

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Eucalyptus Wood Smoke Extract Elicits a Dose-Dependent Effect in Brain Endothelial Cells.
Dorothy J You, Bria M Gorman, Noah Goshi, Nicholas R Hum, Aimy Sebastian

Int J Mol Sci· September 2024

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Host tracheal and intestinal microbiomes inhibit growth .
Susana Tejeda-Garibay, Lihong Zhao, Nicholas R Hum, Maria Pimentel, Anh L Diep

Microbiol Spectr· July 2024

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Simulated Microgravity Alters Gene Regulation Linked to Immunity and Cardiovascular Disease.
Candice G T Tahimic, Sonette Steczina, Aimy Sebastian, Nicholas R Hum, Metadel Abegaz

Genes (Basel)· July 2024

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Mef2c regulates bone mass through Sost-dependent and -independent mechanisms.
Cesar Morfin, Aimy Sebastian, Stephen P Wilson, Beheshta Amiri, Deepa K Murugesh, Nicholas R Hum

Bone· February 2024

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Loss of Cadherin-11 in pancreatic ductal adenocarcinoma alters tumor-immune microenvironment.
Aimy Sebastian, Kelly A Martin, Ivana Peran, Nicholas R Hum, Nicole F Leon

Front Oncol· October 2023

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Host tracheal and intestinal microbiomes inhibit growth .
Susana Tejeda-Garibay, Lihong Zhao, Nicholas R Hum, Maria Pimentel, Anh L Diep

bioRxiv· October 2023

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Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening.
Katherine H Griffin, Steven W Thorpe, Aimy Sebastian, Nicholas R Hum, Thomas P Coonan

Proc Natl Acad Sci U S A· September 2023

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Isolation of Murine Articular Chondrocytes for Single-Cell RNA or Bulk RNA Sequencing Analysis.
Jillian L McCool, Nicholas R Hum, Aimy Sebastian, Gabriela G Loots

Methods Mol Biol· November 2022

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Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis.
Aimy Sebastian, Nicholas R Hum, Jillian L McCool, Stephen P Wilson, Deepa K Murugesh

Front Immunol· August 2022

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Dose-dependent consequences of sub-chronic fentanyl exposure on neuron and glial co-cultures.
Doris Lam, Aimy Sebastian, Chandrakumar Bogguri, Nicholas R Hum, Alexander Ladd

Front Toxicol· August 2022

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IL-17A Increases Doxorubicin Efficacy in Triple Negative Breast Cancer.
Nicholas R Hum, Aimy Sebastian, Kelly A Martin, Naiomy D Rios-Arce, Sean F Gilmore

Front Oncol· July 2022

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Interactions Between Diabetes Mellitus and Osteoarthritis: From Animal Studies to Clinical Data.
Naiomy D Rios-Arce, Nicholas R Hum, Gabriela G Loots

JBMR Plus· May 2022

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Preexisting Type 1 Diabetes Mellitus Blunts the Development of Posttraumatic Osteoarthritis.
Naiomy D Rios-Arce, Deepa K Murugesh, Nicholas R Hum, Aimy Sebastian, Elias H Jbeily

JBMR Plus· May 2022

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MAVS mediates a protective immune response in the brain to Rift Valley fever virus.
Nicholas R Hum, Feliza A Bourguet, Aimy Sebastian, Doris Lam, Ashlee M Phillips

PLoS Pathog· May 2022

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Extracellular matrix modulates T cell clearance of malignant cells in vitro.
Claire Robertson, Aimy Sebastian, Aubree Hinckley, Naiomy D Rios-Arce, William F Hynes, Nicholas R Hum

Biomaterials· March 2022

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Sclerostin Depletion Induces Inflammation in the Bone Marrow of Mice.
Cristine Donham, Betsabel Chicana, Alexander G Robling, Asmaa Mohamed, Sonny Elizaldi, Nicholas R Hum

Int J Mol Sci· August 2021

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