Publications by authors named "Nik Zainal"

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Molecular profiling of the Basal-like intrinsic molecular subtype in primary ER-positive HER2-negative breast cancer.
Lennart Hohmann, Deborah F Nacer, Mattias Aine, Yasin Memari, Daniella Black, Serena Nik-Zainal

Genome Med· December 2025

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A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription.
Anna Minello, Jesus Gomez-Escudero, Sreerama Chaitanya Sridhara, Charlotte Martin, Elodie Girard, Serena Nik-Zainal

Nat Commun· December 2025

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Clinical potential of whole-genome data linked to mortality statistics in patients with breast cancer in the UK: a retrospective analysis.
Daniella Black, Helen Ruth Davies, Gene Ching Chiek Koh, Lucia Chmelova, Marko Cubric, Serena Nik-Zainal

Lancet Oncol· November 2025

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Hierarchical Coordination of Polymerase Theta and RAD51 Resolves Clustered Replication Fork Collapse.
Chelsea M Smith, Dennis A Simpson, Paolo Guerra, Wanjuan Feng, Simon W Ellington, Serena Nik-Zainal

bioRxiv· July 2025

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Metastatic malignant cylindroma arising on a background of digenic inheritance of BRCA2 and CYLD pathogenic variants targeted with PARP inhibition.
William Fostier, Akhtar Husain, Shirin Namini, Bipin Mathew, Georgie Holt, Serena Nik-Zainal

Clin Exp Dermatol· June 2025

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A redefined InDel taxonomy provides insights into mutational signatures.
Gene Ching Chiek Koh, Arjun Scott Nanda, Giuseppe Rinaldi, Soraya Boushaki, Andrea Degasperi, Serena Nik-Zainal

Nat Genet· May 2025

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Genomic characterization of the HER2-enriched intrinsic molecular subtype in primary ER-positive HER2-negative breast cancer.
Lennart Hohmann, Kristin Sigurjonsdottir, Ana Bosch Campos, Deborah F Nacer, Srinivas Veerla, Serena Nik-Zainal

Nat Commun· March 2025

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Origins and impact of extrachromosomal DNA.
Chris Bailey, Oriol Pich, Kerstin Thol, Thomas B K Watkins, Jens Luebeck, Serena Nik-Zainal

Nature· November 2024

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Large-scale analysis of whole genome sequencing data from formalin-fixed paraffin-embedded cancer specimens demonstrates preservation of clinical utility.
Shadi Basyuni, Laura Heskin, Andrea Degasperi, Daniella Black, Gene C C Koh, Serena Nik-Zainal

Nat Commun· September 2024

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Prof. Serena Nik-Zainal.
Serena Nik-Zainal

Cell Rep Med· September 2024

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Insights from multi-omic modeling of neurodegeneration in xeroderma pigmentosum using an induced pluripotent stem cell system.
Cherif Badja, Sophie Momen, Gene Ching Chiek Koh, Soraya Boushaki, Theodoros I Roumeliotis, Serena Nik-Zainal

Cell Rep· June 2024

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The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells.
Gene Ching Chiek Koh, Soraya Boushaki, Salome Jingchen Zhao, Andrew Marcel Pregnall, Firas Sadiyah, Serena Nik-Zainal

Nat Genet· January 2024

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Prevalence and significance of DDX41 gene variants in the general population.
Sruthi Cheloor Kovilakam, Muxin Gu, William G Dunn, Ludovica Marando, Clea Barcena, Serena Nik-Zainal

Blood· October 2023

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Obesity-associated changes in molecular biology of primary breast cancer.
Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Samuel Aparicio, Ayse Bassez, Serena Nik-Zainal

Nat Commun· July 2023

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Non-BRCA1/BRCA2 high-risk familial breast cancers are not associated with a high prevalence of BRCAness.
Lars V B Andersen, Martin J Larsen, Helen Davies, Andrea Degasperi, Henriette Roed Nielsen, Serena Nik-Zainal

Breast Cancer Res· June 2023

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A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression.
Stefan J Hutten, Roebi de Bruijn, Catrin Lutz, Madelon Badoux, Timo Eijkman, Serena Nik-Zainal

Cancer Cell· May 2023

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Diagnosis of Ovarian Carcinoma Homologous Recombination DNA Repair Deficiency From Targeted Gene Capture Oncology Assays.
Niklas Krumm, Nithisha S Khasnavis, Marc Radke, Kalyan Banda, Helen R Davies, Serena Nik-Zainal

JCO Precis Oncol· May 2023

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Genomic characterisation of hormone receptor-positive breast cancer arising in very young women.
S J Luen, G Viale, S Nik-Zainal, P Savas, R Kammler

Ann Oncol· April 2023

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Correction to: Basal expression of RAD51 foci predicts olaparib response in patient-derived ovarian cancer xenografts.
F Guffanti, M F Alvisi, A Anastasia, F Ricci, M Chiappa, S Nik-Zainal

Br J Cancer· March 2023

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Author Correction: Learning to distinguish progressive and non-progressive ductal carcinoma in situ.
Anna K Casasent, Mathilde M Almekinders, Charlotta Mulder, Proteeti Bhattacharjee, Deborah Collyar, Serena Nik-Zainal

Nat Rev Cancer· February 2023

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Learning to distinguish progressive and non-progressive ductal carcinoma in situ.
Anna K Casasent, Mathilde M Almekinders, Charlotta Mulder, Proteeti Bhattacharjee, Deborah Collyar, Serena Nik-Zainal

Nat Rev Cancer· December 2022

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A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer.
Marine Inglebert, Martina Dettwiler, Kerstin Hahn, Anna Letko, Cord Drogemuller, Serena Nik-Zainal

Sci Rep· October 2022

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Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer.
Erika Durinikova, Nicole M Reilly, Kristi Buzo, Elisa Mariella, Rosaria Chilà, Serena Nik-Zainal

Clin Cancer Res· September 2022

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Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells.
Foad J Rouhani, Xueqing Zou, Petr Danecek, Cherif Badja, Tauanne Dias Amarante, Serena Nik-Zainal

Nat Genet· September 2022

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Substitution mutational signatures in whole-genome-sequenced cancers in the UK population.
Andrea Degasperi, Xueqing Zou, Tauanne Dias Amarante, Andrea Martinez-Martinez, Gene Ching Chiek Koh, Serena Nik-Zainal

Science· April 2022

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