Publications by authors named "Ozkan Is"

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Multi Layered Omics Approaches Reveal Glia Specific Alterations in Alzheimer's Disease: A Systematic Review and Future Prospects.
Özkan İş, Yuhao Min, Xue Wang, Stephanie R Oatman, Ann Abraham Daniel

Glia· March 2025

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Cell-specific transcriptional signatures of vascular cells in Alzheimer's disease: perspectives, pathways, and therapeutic directions.
Soumilee Chaudhuri, Minyoung Cho, Julia C Stumpff, Paula J Bice, Özkan İş

Mol Neurodegener· January 2025

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ε4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer's disease.
Prabesh Bhattarai, Elanur Yilmaz, Elif Öykü Cakir, Hande Yüceer Korkmaz, Annie J Lee, Elizabeth Fisher

bioRxiv· January 2025

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ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling.
Hüseyin Tayran, Elanur Yilmaz, Prabesh Bhattarai, Yuhao Min, Xue Wang, Nathalie Jurisch-Yaksi, Takahisa Kanekiyo

Cell Genom· September 2024

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Gliovascular transcriptional perturbations in Alzheimer's disease reveal molecular mechanisms of blood brain barrier dysfunction.
Özkan İş, Xue Wang, Joseph S Reddy, Yuhao Min, Elanur Yilmaz, Takahisa Kanekiyo, Laura J Lewis-Tuffin, Melissa E Murray, Dennis W Dickson

Nat Commun· June 2024

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ABCA7-dependent Neuropeptide-Y signalling is a resilience mechanism required for synaptic integrity in Alzheimer's disease.
Hüseyin Tayran, Elanur Yilmaz, Prabesh Bhattarai, Yuhao Min, Xue Wang

bioRxiv· January 2024

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Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy.
Yuhao Min, Xue Wang, Özkan İş, Tulsi A Patel, Junli Gao, Dennis W Dickson

Nat Commun· November 2023

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Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease.
Tohid Siddiqui, Mehmet Ilyas Cosacak, Stanislava Popova, Prabesh Bhattarai, Elanur Yilmaz, Ismael Santa-Maria

NPJ Regen Med· July 2023

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Alzheimer's disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions.
Xue Wang, Mariet Allen, Özkan İş, Joseph S Reddy, Frederick Q Tutor-New, Melissa E Murray, Dennis W Dickson

J Clin Invest· January 2022

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Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer's disease.
Joseph S Reddy, Mariet Allen, Charlotte C G Ho, Stephanie R Oatman, Özkan İş, Takahisa Kanekiyo, Melissa E Murray, Dennis W Dickson

Acta Neuropathol Commun· May 2021

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