Publications by authors named "Peter Backx"

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Minimally Invasive Model of Mitral Regurgitation in Mice.
Jian Wu, Xuan Li, Xiang Li, Robert Lakin, Jieyun You, Peter H Backx

Circ Res· December 2025

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Adiponectin-receptor agonism prevents right ventricular tissue pathology in a mouse model of Duchenne muscular dystrophy.
Shivam Gandhi, Luca J Delfinis, Parashar D Bhatt, Madison C Garibotti, Catherine A Bellissimo, Peter H Backx

Mol Metab· September 2025

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Atrial Fibrillation Related Titin Truncation Is Associated With Atrial Myopathy in Patient-Derived Induced Pluripotent Stem Cell Disease Models.
Kate Huang, Mishal Ashraf, Leili Rohani, Yinhan Luo, Ardin Sacayanan, Peter H Backx

Circ Genom Precis Med· February 2025

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Mitohormesis during advanced stages of Duchenne muscular dystrophy reveals a redox-sensitive creatine pathway that can be enhanced by the mitochondrial-targeting peptide SBT-20.
Meghan C Hughes, Sofhia V Ramos, Aditya N Brahmbhatt, Patrick C Turnbull, Nazari N Polidovitch, Peter H Backx

Redox Biol· October 2024

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Primitive macrophages induce sarcomeric maturation and functional enhancement of developing human cardiac microtissues via efferocytic pathways.
Homaira Hamidzada, Simon Pascual-Gil, Qinghua Wu, Gregory M Kent, Stéphane Massé, Peter H Backx

Nat Cardiovasc Res· May 2024

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The effects of daily dose of intense exercise on cardiac responses and atrial fibrillation.
Renée A Gorman, Simona Yakobov, Nazari Polidovitch, Ryan Debi, Victoria C Sanfrancesco, Peter H Backx

J Physiol· February 2024

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Cardiomyocyte and endothelial cells play distinct roles in the tumour necrosis factor (TNF)-dependent atrial responses and increased atrial fibrillation vulnerability induced by endurance exercise training in mice.
Robert Lakin, Nazari Polidovitch, Sibao Yang, Mihir Parikh, Xueyan Liu, Peter H Backx

Cardiovasc Res· December 2023

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TAK1 Activation by NLRP3 Deficiency Confers Cardioprotection Against Pressure Overload-Induced Cardiomyocyte Pyroptosis and Hypertrophy.
Xuan Li, Jieyun You, Fangjie Dai, Shijun Wang, Feng Hua Yang, Peter H Backx

JACC Basic Transl Sci· December 2023

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Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation.
Marianne Wauchop, Naimeh Rafatian, Yimu Zhao, Wenliang Chen, Mark Gagliardi, Peter H Backx

Biomaterials· October 2023

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Apelin receptor inhibition in ischemia-reperfused mouse hearts protected by endogenous n-3 polyunsaturated fatty acids.
Shuang Zheng, Weijiang Tan, Xiang Li, Lijing Wang, Caiyi Zhu, Peter H Backx

Front Pharmacol· October 2023

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Proteomics and phosphoproteomics of failing human left ventricle identifies dilated cardiomyopathy-associated phosphorylation of CTNNA3.
Cristine J Reitz, Marjan Tavassoli, Da Hye Kim, Saumya Shah, Robert Lakin, Peter H Backx

Proc Natl Acad Sci U S A· May 2023

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Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.
Allen C T Teng, Liyang Gu, Michelle Di Paola, Robert Lakin, Zachary J Williams, Peter H Backx

Nat Commun· October 2022

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Irx5 and transient outward K currents contribute to transmural contractile heterogeneities in the mouse ventricle.
Kyoung-Han Kim, Yena Oh, Jie Liu, Saif Dababneh, Ying Xia, Peter H Backx

Am J Physiol Heart Circ Physiol· May 2022

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Differential mRNA Expression and Circular RNA-Based Competitive Endogenous RNA Networks in the Three Stages of Heart Failure in Transverse Aortic Constriction Mice.
Xiang Li, Weijiang Tan, Shuang Zheng, W Glen Pyle, Caiyi Zhu, Peter H Backx

Front Physiol· March 2022

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Cardioprotective Effects of n-3 Polyunsaturated Fatty Acids: Orchestration of mRNA Expression, Protein Phosphorylation, and Lipid Metabolism in Pressure Overload Hearts.
Xiang Li, Weijiang Tan, Shuang Zheng, Junjie Zhang, Caiyi Zhu, Peter H Backx

Front Cardiovasc Med· January 2022

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Aged Monkeys Fed a High-Fat/High-Sugar Diet Recapitulate Metabolic Disorders and Cardiac Contractile Dysfunction.
Shuang Zheng, Weijiang Tan, Xiang Li, Binglin Li, Baoyong Gong, Peter H Backx

J Cardiovasc Transl Res· October 2021

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Dissecting the Roles of the Autonomic Nervous System and Physical Activity on Circadian Heart Rate Fluctuations in Mice.
Nour Barazi, Nazari Polidovitch, Ryan Debi, Simona Yakobov, Robert Lakin, Peter H Backx

Front Physiol· October 2021

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Understanding the role of Iroquois homeobox transcription factor 5 (IRX5) in cardiac function: getting to the (human) heart of the matter.
Kyoung-Han Kim, Peter H Backx

Cardiovasc Res· July 2021

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A Porcine Model of Heart Failure With Preserved Ejection Fraction Induced by Chronic Pressure Overload Characterized by Cardiac Fibrosis and Remodeling.
Weijiang Tan, Xiang Li, Shuang Zheng, Xiaohui Li, Xiaoshen Zhang, Peter H Backx

Front Cardiovasc Med· June 2021

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Differential negative effects of acute exhaustive swim exercise on the right ventricle are associated with disproportionate hemodynamic loading.
Robert Lakin, Ryan Debi, Sibao Yang, Nazari Polidovitch, Jack M Goodman, Peter H Backx

Am J Physiol Heart Circ Physiol· April 2021

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Transcriptomic Bioinformatic Analyses of Atria Uncover Involvement of Pathways Related to Strain and Post-translational Modification of Collagen in Increased Atrial Fibrillation Vulnerability in Intensely Exercised Mice.
Yena Oh, Sibao Yang, Xueyan Liu, Sayantan Jana, Farzad Izaddoustdar, Peter H Backx

Front Physiol· December 2020

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Apelin increases atrial conduction velocity, refractoriness, and prevents inducibility of atrial fibrillation.
Young M Kim, Robert Lakin, Hao Zhang, Jack Liu, Ayaaz Sachedina, Peter H Backx

JCI Insight· September 2020

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Revisiting right anterior oblique projections for the triangle of Koch: implications from computed tomography.
Yanjing Wang, Lin Liu, Robert Lakin, Nazari Polidovitch, Guohui Liu, Peter H Backx

BMC Cardiovasc Disord· August 2020

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Slit2 Protects Hearts Against Ischemia-Reperfusion Injury by Inhibiting Inflammatory Responses and Maintaining Myofilament Contractile Properties.
Xiang Li, Shuang Zheng, Weijiang Tan, Hongqi Chen, Xiaohui Li, Peter H Backx

Front Physiol· March 2020

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Left ventricular response in the transition from hypertrophy to failure recapitulates distinct roles of Akt, β-arrestin-2, and CaMKII in mice with aortic regurgitation.
Jian Wu, Jieyun You, Xiaoyan Wang, Shijun Wang, Jiayuan Huang, Peter H Backx

Ann Transl Med· March 2020

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