Publications by authors named "Peter Dervan"

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RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.
Juntaek Oh, Tiezheng Jia, Jun Xu, Jenny Chong, Peter B Dervan

Proc Natl Acad Sci U S A· January 2022

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Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome.
Paul B Finn, Devesh Bhimsaria, Asfa Ali, Asuka Eguchi, Aseem Z Ansari, Peter B Dervan

PLoS One· February 2021

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Repression of the transcriptional activity of ERRα with sequence-specific DNA-binding polyamides.
Chien-Yu Chen, Yang Li, Tiezheng Jia, Lina He, Alissa A Hare, Peter B Dervan

Med Chem Res· April 2020

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Sequence specific suppression of androgen receptor-DNA binding in vivo by a Py-Im polyamide.
Alexis A Kurmis, Peter B Dervan

Nucleic Acids Res· May 2019

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Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide.
Silvia Diaz-Perez, Nathanael Kane, Alexis A Kurmis, Fei Yang, Nicolas T Kummer, Peter B Dervan

PLoS One· July 2018

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Structural basis for the initiation of eukaryotic transcription-coupled DNA repair.
Jun Xu, Indrajit Lahiri, Wei Wang, Adam Wier, Michael A Cianfrocco, Peter B Dervan

Nature· November 2017

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A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer.
Alexis A Kurmis, Fei Yang, Timothy R Welch, Nicholas G Nickols, Peter B Dervan

Cancer Res· May 2017

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RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif.
Liang Xu, Wei Wang, Deanna Gotte, Fei Yang, Alissa A Hare, Peter B Dervan

Proc Natl Acad Sci U S A· November 2016

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Ahmed H. Zewail (1946-2016).
Peter B Dervan

Science· September 2016

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Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich's Ataxia Cells.
Jeannine Gerhardt, Angela D Bhalla, Jill Sergesketter Butler, James W Puckett, Peter B Dervan

Cell Rep· August 2016

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Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.
Amanda E Hargrove, Thomas F Martinez, Alissa A Hare, Alexis A Kurmis, John W Phillips, Peter B Dervan

PLoS One· June 2016

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An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors.
Jerzy O Szablowski, Jevgenij A Raskatov, Peter B Dervan

Mol Cancer Ther· April 2016

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A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity.
Veena S Mysore, Jerzy Szablowski, Peter B Dervan, Patrick J Frost

Mol Cancer Res· March 2016

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A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma.
JeenJoo S Kang, Peter B Dervan

Q Rev Biophys· November 2015

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Tumor xenograft uptake of a pyrrole-imidazole (Py-Im) polyamide varies as a function of cell line grafted.
Jevgenij A Raskatov, Jerzy O Szablowski, Peter B Dervan

J Med Chem· October 2014

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Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.
Thomas F Martínez, John W Phillips, Kenneth K Karanja, Piotr Polaczek, Chieh-Mei Wang, Peter B Dervan

Nucleic Acids Res· October 2014

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A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor.
Jevgenij A Raskatov, James W Puckett, Peter B Dervan

Bioorg Med Chem· August 2014

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Design of sequence-specific DNA binding molecules for DNA methyltransferase inhibition.
JeenJoo S Kang, Jordan L Meier, Peter B Dervan

J Am Chem Soc· March 2014

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Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit.
Fei Yang, Nicholas G Nickols, Benjamin C Li, Jerzy O Szablowski, Shari R Hamilton, Peter B Dervan

J Med Chem· September 2013

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Activity of a Py-Im polyamide targeted to the estrogen response element.
Nicholas G Nickols, Jerzy O Szablowski, Amanda E Hargrove, Benjamin C Li, Jevgenij A Raskatov, Peter B Dervan

Mol Cancer Ther· May 2013

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Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus.
Jonathan S Edwards, Laurie Betts, Monica L Frazier, Rebecca M Pollet, Stephen M Kwong, Peter B Dervan

Proc Natl Acad Sci U S A· February 2013

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Synthesis of cyclic Py-Im polyamide libraries.
Benjamin C Li, David C Montgomery, James W Puckett, Peter B Dervan

J Org Chem· January 2013

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Antitumor activity of a pyrrole-imidazole polyamide.
Fei Yang, Nicholas G Nickols, Benjamin C Li, Georgi K Marinov, Jonathan W Said, Peter B Dervan

Proc Natl Acad Sci U S A· January 2013

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Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide.
Jevgenij A Raskatov, Nicholas G Nickols, Amanda E Hargrove, Georgi K Marinov, Barbara Wold, Peter B Dervan

Proc Natl Acad Sci U S A· October 2012

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Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing.
Jordan L Meier, Abigail S Yu, Ian Korf, David J Segal, Peter B Dervan

J Am Chem Soc· October 2012

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