Publications by authors named "Philip D Compton"

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A Robust and Automated Platform for Charge Detection Mass Spectrometry of Megadalton Biotherapeutics.
Samuel E Janisse, Ryan T Fellers, Shannon A Raab, Michael P Goodwin, Kyle P Bowen, Zhirui J Lian, Kenneth R Durbin, Michael W Senko, Philip D Compton, Jared O Kafader

Anal Chem· March 2025

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Automated Enzymatic Deglycosylation of Monoclonal Antibody with the SampleStream Platform.
Troy D Fisher, Philip D Compton, Matthew T Robey, Ryan T Fellers, Kenneth R Durbin

J Am Soc Mass Spectrom· December 2025

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Standardized workflow for multiplexed charge detection mass spectrometry on orbitrap analyzers.
Pei Su, John P McGee, Michael A R Hollas, Ryan T Fellers, Kenneth R Durbin, Philip D Compton

Nat Protoc· June 2025

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Automated Immunoprecipitation, Sample Preparation, and Individual Ion Mass Spectrometry Platform for Proteoforms.
Benjamin J Des Soye, John P McGee, Michael A R Hollas, Eleonora Forte, Ryan T Fellers, Philip D Compton

Anal Chem· August 2024

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High-Throughput Analyses of Therapeutic Antibodies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry Combined with SampleStream and Intact Protein Mass Spectrometry.
Rachel Liuqing Shi, Michael A Dillon, Philip D Compton, William S Sawyer, John R Thorup

Anal Chem· November 2023

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Automated Control of Injection Times for Unattended Acquisition of Multiplexed Individual Ion Mass Spectra.
John P McGee, Michael W Senko, Kevin Jooß, Benjamin J Des Soye, Philip D Compton

Anal Chem· December 2022

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Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire.
Rafael D Melani, Benjamin J Des Soye, Jared O Kafader, Eleonora Forte, Michael Hollas, Philip D Compton

J Proteome Res· January 2022

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Spectrum of Apolipoprotein AI and Apolipoprotein AII Proteoforms and Their Associations With Indices of Cardiometabolic Health: The CARDIA Study.
John T Wilkins, Henrique S Seckler, Jonathan Rink, Philip D Compton, Luca Fornelli

J Am Heart Assoc· September 2021

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New Interface for Faster Proteoform Analysis: Immunoprecipitation Coupled with SampleStream-Mass Spectrometry.
Henrique Dos Santos Seckler, Hae-Min Park, Cameron M Lloyd-Jones, Rafael D Melani, Jeannie M Camarillo, Philip D Compton

J Am Soc Mass Spectrom· July 2021

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Next-generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire.
Rafael D Melani, Benjamin J Des Soye, Jared O Kafader, Eleonora Forte, Michael Hollas, Philip D Compton

medRxiv· July 2021

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Isotopic Resolution of Protein Complexes up to 466 kDa Using Individual Ion Mass Spectrometry.
John P McGee, Rafael D Melani, Ping F Yip, Michael W Senko, Philip D Compton

Anal Chem· February 2021

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Targeted detection and quantitation of histone modifications from 1,000 cells.
Nebiyu A Abshiru, Jacek W Sikora, Jeannie M Camarillo, Juliette A Morris, Philip D Compton

PLoS One· December 2020

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Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes.
Jared O Kafader, Rafael D Melani, Kenneth R Durbin, Bon Ikwuagwu, Bryan P Early, Philip D Compton

Nat Methods· April 2020

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Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions.
Jared O Kafader, Rafael D Melani, Luis F Schachner, Ashley N Ives, Steven M Patrie, Philip D Compton

J Am Soc Mass Spectrom· March 2020

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Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top-Down Mass Spectrometry.
Jared O Kafader, Kenneth R Durbin, Rafael D Melani, Benjamin J Des Soye, Luis F Schachner, Philip D Compton

J Proteome Res· March 2020

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Voltage Rollercoaster Filtering of Low-Mass Contaminants During Native Protein Analysis.
John P McGee, Rafael D Melani, Michael Goodwin, Graeme McAlister, Romain Huguet, Philip D Compton

J Am Soc Mass Spectrom· March 2020

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Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics.
Luca Fornelli, Kristina Srzentić, Timothy K Toby, Peter F Doubleday, Romain Huguet, Philip D Compton

Mol Cell Proteomics· February 2020

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Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry.
Hae-Min Park, Valerie J Winton, Jared J Drader, Sheri Manalili Wheeler, Greg A Lazar, Philip D Compton

Anal Chem· January 2020

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STORI Plots Enable Accurate Tracking of Individual Ion Signals.
Jared O Kafader, Steven C Beu, Bryan P Early, Rafael D Melani, Kenneth R Durbin, Philip D Compton

J Am Soc Mass Spectrom· November 2019

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Standard Proteoforms and Their Complexes for Native Mass Spectrometry.
Luis F Schachner, Ashley N Ives, John P McGee, Rafael D Melani, Jared O Kafader, Philip D Compton

J Am Soc Mass Spectrom· July 2019

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A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies.
Erika N Cline, Arighno Das, Maíra Assunção Bicca, Saad N Mohammad, Luis F Schachner, Philip D Compton

J Neurochem· March 2019

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Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins.
Jared O Kafader, Rafael D Melani, Michael W Senko, Alexander A Makarov, Neil L Kelleher, Philip D Compton

Anal Chem· February 2019

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Estimating the Distribution of Protein Post-Translational Modification States by Mass Spectrometry.
Philip D Compton, Neil L Kelleher, Jeremy Gunawardena

J Proteome Res· August 2018

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Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques.
Luca Fornelli, Kristina Srzentić, Romain Huguet, Christopher Mullen, Seema Sharma, Philip D Compton

Anal Chem· July 2018

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A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity.
Henrique Dos Santos Seckler, Luca Fornelli, R Kannan Mutharasan, C Shad Thaxton, Ryan Fellers, Philip D Compton

J Proteome Res· June 2018

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