Publications by authors named "Philip D Kiser"

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Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa.
Josie A Silvaroli, Matthew J Pleshinger, Surajit Banerjee, Philip D Kiser, Marcin Golczak

ACS Chem Biol· September 2017

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Retinol tracing within murine neural retina reveals cell type-specific retinol transport and distribution.
Zachary J Engfer, Grazyna Palczewska, Samuel W Du, Jianye Zhang, Zhiqian Dong, Philip D Kiser

J Clin Invest· November 2025

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The molecular mechanisms of visual chromophore release from cellular retinaldehyde-binding protein.
Daniel Santos, Lorenzo Foglia, Philip D Kiser, Alvin Yu

Structure· August 2025

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Rationally Designed, Short-Acting RPE65 Inhibitors for Visual Cycle-Associated Retinopathies.
Marco Bassetto, Yulun Hu, Bowen Li, Xiuyuan Chen, Vivek Saraswat, Philip D Kiser

J Med Chem· August 2025

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Spectroscopy and crystallography define carotenoid oxygenases as a new subclass of mononuclear non-heme Fe enzymes.
Dory E DeWeese, Michael P Everett, Jeffrey T Babicz, Anahita Daruwalla, Edward I Solomon, Philip D Kiser

J Biol Chem· May 2025

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Advances and therapeutic opportunities in visual cycle modulation.
Jordan Zaluski, Marco Bassetto, Philip D Kiser, Gregory P Tochtrop

Prog Retin Eye Res· May 2025

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Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations.
Rafał Hołubowicz, Samuel W Du, Jiin Felgner, Roman Smidak, Elliot H Choi, Philip D Kiser

Nat Biomed Eng· January 2025

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Insights into the Activation and Self-Association of Arrestin-1.
David Salom, Philip D Kiser, Krzysztof Palczewski

Biochemistry· January 2025

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Mechanisms of amphibian arrestin 1 self-association and dynamic distribution in retinal photoreceptors.
Cassandra L Barnes, David Salom, Kevin E W Namitz, W Clay Smith, Bruce A Knutson, Philip D Kiser

J Biol Chem· December 2024

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Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis.
Yasmeen J Solano, Philip D Kiser

Trends Biochem Sci· August 2024

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A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models.
Henri Leinonen, Jianye Zhang, Laurence M Occelli, Umair Seemab, Elliot H Choi, Philip D Kiser

Nat Commun· July 2024

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Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore.
Yasmeen J Solano, Michael P Everett, Kelly S Dang, Jude Abueg, Philip D Kiser

Nat Chem Biol· June 2024

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Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice.
Dominik Lewandowski, Fangyuan Gao, Sanae Imanishi, Aleksander Tworak, Marco Bassetto, Philip D Kiser

J Biol Chem· May 2024

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Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors.
Marco Bassetto, Alexander V Kolesnikov, Dominik Lewandowski, Jianying Z Kiser, Maximilian Halabi, Philip D Kiser

Cell Rep· May 2024

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Retinylidene chromophore hydrolysis from mammalian visual and non-visual opsins.
John D Hong, David Salom, Elliot H Choi, Samuel W Du, Aleksander Tworak, Philip D Kiser

J Biol Chem· March 2024

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Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia.
Aleksander Tworak, Alexander V Kolesnikov, John D Hong, Elliot H Choi, Jennings C Luu, Philip D Kiser

Cell Rep· August 2023

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Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain.
Arum Wu, David Salom, John D Hong, Aleksander Tworak, Kohei Watanabe, Philip D Kiser

Nat Commun· August 2023

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Tuning the Metabolic Stability of Visual Cycle Modulators through Modification of an RPE65 Recognition Motif.
Marco Bassetto, Jordan Zaluski, Bowen Li, Jianye Zhang, Mohsen Badiee, Philip D Kiser

J Med Chem· June 2023

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Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition.
Jennings C Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Philip D Kiser

Proc Natl Acad Sci U S A· May 2023

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Chromophore hydrolysis and release from photoactivated rhodopsin in native membranes.
John D Hong, David Salom, Michał Andrzej Kochman, Adam Kubas, Philip D Kiser

Proc Natl Acad Sci U S A· November 2022

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Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration.
Carey Y L Huh, Henri Leinonen, Taylor Nakayama, Julia R Tomasello, Jianye Zhang, Jianying Z Kiser, Philip D Kiser

Curr Biol· October 2022

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Preparation of carotenoid cleavage dioxygenases for X-ray crystallography.
Anahita Daruwalla, Xuewu Sui, Philip D Kiser

Methods Enzymol· July 2022

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Retinal pigment epithelium 65 kDa protein (RPE65): An update.
Philip D Kiser

Prog Retin Eye Res· May 2022

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A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype.
Laurence M Occelli, Anahita Daruwalla, Samantha R De Silva, Paige A Winkler, Kelian Sun, Philip D Kiser

Hum Mol Genet· April 2022

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Structural evidence for visual arrestin priming via complexation of phosphoinositols.
Christopher L Sander, Jennings Luu, Kyumhyuk Kim, David Furkert, Kiyoung Jang, Philip D Kiser

Structure· February 2022

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Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition.
Christopher L Sander, Avery E Sears, Antonio F M Pinto, Elliot H Choi, Shirin Kahremany, Philip D Kiser

J Cell Biol· August 2021

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