Publications by authors named "Prakash Radhakrishnan"

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Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein.
Satish Sagar, Ashok Kumar Rathinavel, William E Lutz, Lucas R Struble, Surender Khurana, Andy T Schnaubelt, Nitish Kumar Mishra, Chittibabu Guda, Nicholas Y Palermo, Mara J Broadhurst

Clin Transl Med· February 2021

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Unraveling the glyco-immunity nexus in pancreatic cancer.
Christabelle Rajesh, Richard D Cummings, Prakash Radhakrishnan

Mol Cancer· August 2025

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Pretargeted alpha therapy in MUC16-positive high-grade serous ovarian cancer.
Kyeara N Mack, David Bauer, Lukas M Carter, Sebastian E Carrasco, Mohamed I Atmane, Prakash Radhakrishnan

Nucl Med Biol· April 2025

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Humanized Anti-MUC16 Antibody-Conjugated Contrast Agents for Magnetic Resonance Imaging of Pancreatic Cancer.
Jayasindu Mathiyazhagan, Christabelle Rajesh, Satish Sagar, Thomas C Caffrey, Ying Huang, Prakash Radhakrishnan

Cancers (Basel)· March 2025

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Decoding the Dynamics of Circulating Tumor DNA in Liquid Biopsies.
Khadija Turabi, Kelsey Klute, Prakash Radhakrishnan

Cancers (Basel)· July 2024

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Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6.
Eric N Aguilar, Satish Sagar, Brandy R Murray, Christabelle Rajesh, Eric K Lei, Prakash Radhakrishnan

Mol Cancer Ther· June 2024

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Interrogating the Theranostic Capacity of a MUC16-Targeted Antibody for Ovarian Cancer.
Kyeara N Mack, Zachary V Samuels, Lukas M Carter, Tara D Viray, Komal Mandleywala, Prakash Radhakrishnan

J Nucl Med· April 2024

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Mucins as contrast agent targets for fluorescence-guided surgery of pancreatic cancer.
Kathryn M Muilenburg, Carly C Isder, Prakash Radhakrishnan, Surinder K Batra, Quan P Ly

Cancer Lett· May 2023

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The (Sialyl) Tn antigen: Contributions to immunosuppression in gastrointestinal cancers.
Christabelle Rajesh, Prakash Radhakrishnan

Front Oncol· January 2023

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Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth.
John Victor Napoleon, Satish Sagar, Sydney P Kubica, Lidia Boghean, Smit Kour, Prakash Radhakrishnan

Proc Natl Acad Sci U S A· May 2022

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Insect cell expression and purification of recombinant SARS-COV-2 spike proteins that demonstrate ACE2 binding.
Lucas R Struble, Audrey L Smith, William E Lutz, Gabrielle Grubbs, Satish Sagar, Prakash Radhakrishnan

Protein Sci· May 2022

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Truncated O-Glycan-Bearing MUC16 Enhances Pancreatic Cancer Cells Aggressiveness via α4β1 Integrin Complexes and FAK Signaling.
Christabelle Rajesh, Satish Sagar, Ashok Kumar Rathinavel, Divya Thomas Chemparathy, Xianlu Laura Peng, Prakash Radhakrishnan

Int J Mol Sci· May 2022

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ImmunoPET of Ovarian and Pancreatic Cancer with AR9.6, a Novel MUC16-Targeted Therapeutic Antibody.
Sai Kiran Sharma, Kyeara N Mack, Alessandra Piersigilli, Jacob Pourat, Kimberly J Edwards, Prakash Radhakrishnan

Clin Cancer Res· March 2022

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IgE-Based Therapeutic Combination Enhances Antitumor Response in Preclinical Models of Pancreatic Cancer.
Spas Dimitrov Markov, Thomas C Caffrey, Kelly A O'Connell, James A Grunkemeyer, Simon Shin, Prakash Radhakrishnan

Mol Cancer Ther· December 2021

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Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy.
Satish Sagar, Sarbjit Singh, Jayapal Reddy Mallareddy, Yogesh A Sonawane, John V Napoleon, Prakash Radhakrishnan

Eur J Med Chem· October 2021

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Isoforms of MUC16 activate oncogenic signaling through EGF receptors to enhance the progression of pancreatic cancer.
Divya Thomas, Satish Sagar, Xiang Liu, Hye-Rim Lee, James A Grunkemeyer, Prakash Radhakrishnan

Mol Ther· April 2021

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MUC4 enhances gemcitabine resistance and malignant behaviour in pancreatic cancer cells expressing cancer-associated short O-glycans.
Satish Sagar, Pramila D Leiphrakpam, Divya Thomas, Kyle L McAndrews, Thomas C Caffrey, Prakash Radhakrishnan

Cancer Lett· April 2021

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Inhibition of the Receptor for Advanced Glycation End Products Enhances the Cytotoxic Effect of Gemcitabine in Murine Pancreatic Tumors.
Priyanka Swami, Kelly A O'Connell, Swetha Thiyagarajan, Ayrianne Crawford, Prathamesh Patil, Prakash Radhakrishnan

Biomolecules· April 2021

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Altered glycosylation in cancer: A promising target for biomarkers and therapeutics.
Divya Thomas, Ashok Kumar Rathinavel, Prakash Radhakrishnan

Biochim Biophys Acta Rev Cancer· January 2021

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Bromelain Inhibits SARS-CoV-2 Infection in VeroE6 Cells.
Satish Sagar, Ashok Kumar Rathinavel, William E Lutz, Lucas R Struble, Surender Khurana, Prakash Radhakrishnan

bioRxiv· September 2020

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Development of a MUC16-Targeted Near-Infrared Fluorescent Antibody Conjugate for Intraoperative Imaging of Pancreatic Cancer.
Madeline T Olson, Nicholas E Wojtynek, Geoffrey A Talmon, Thomas C Caffrey, Prakash Radhakrishnan

Mol Cancer Ther· August 2020

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Role of Tumor and Stroma-Derived IGF/IGFBPs in Pancreatic Cancer.
Divya Thomas, Prakash Radhakrishnan

Cancers (Basel)· May 2020

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Pancreatic Stellate Cells: The Key Orchestrator of The Pancreatic Tumor Microenvironment.
Divya Thomas, Prakash Radhakrishnan

Adv Exp Med Biol· February 2020

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Invasive phenotype induced by low extracellular pH requires mitochondria dependent metabolic flexibility.
Simon C Shin, Divya Thomas, Prakash Radhakrishnan, Michael A Hollingsworth

Biochem Biophys Res Commun· February 2020

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Truncated O-glycans promote epithelial-to-mesenchymal transition and stemness properties of pancreatic cancer cells.
Divya Thomas, Satish Sagar, Thomas Caffrey, Paul M Grandgenett, Prakash Radhakrishnan

J Cell Mol Med· October 2019

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