Publications by authors named "R Lesche"

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Identification of NUV-244 as a PNPLA3 I148M degrading small molecule.
Patrick Steigemann, Nico Braeuer, Vera Puetter, Nina Zablowsky, Katrin Juenemann, Ralf Lesche

iScience· May 2025

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Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling.
Keith Graham, Philip Lienau, Benjamin Bader, Stefan Prechtl, Jan Naujoks, Ralf Lesche

Cell Chem Biol· July 2024

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Velcrin molecular glues induce apoptosis in glioblastomas with high and expression.
Elisa Aquilanti, Silvia Goldoni, Andrew Baker, Kristyna Kotynkova, Sawyer Andersen, Ralf Lesche

Neurooncol Adv· July 2024

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Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis.
Tatsuo Sugawara, Ekaterina Nevedomskaya, Simon Heller, Annika Böhme, Ralf Lesche

Mol Oncol· March 2024

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Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy.
Christina Kober, Julian Roewe, Norbert Schmees, Lars Roese, Ulrike Roehn, Ralf Lesche

J Immunother Cancer· November 2023

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