Publications by authors named "R. Mark Simpson"

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Capacity for Compensatory Cyclin D2 Response Confers Trametinib Resistance in Canine Mucosal Melanoma.
Bih-Rong Wei, Vincenzo Verdi, Shuling Zhang, Beverly A Mock, Heather R Shive, R Mark Simpson

Cancers (Basel)· July 2025

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Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis.
Vishaka Gopalan, Chun Wai Wong, Rotem Leshem, Luke Owen, Tuulia Vallius, R Mark Simpson

bioRxiv· July 2025

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Capacity for compensatory cyclin D2 response confers trametinib resistance in canine mucosal melanoma.
Bih-Rong Wei, Vincenzo Verdi, Shuling Zhang, Beverly A Mock, Heather R Shive, R Mark Simpson

bioRxiv· April 2025

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Tongue orthotopic xenografts to study fusion-negative rhabdomyosarcoma invasion and metastasis in live animals.
Sarah M Hammoudeh, Yeap Ng, Bih-Rong Wei, Thomas D Madsen, Mukesh P Yadav, R Mark Simpson

Cell Rep Methods· July 2024

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Fusion-negative rhabdomyosarcoma orthotopic tongue xenografts for study of invasion, intravasation and metastasis in live animals.
Sarah M Hammoudeh, Yeap Ng, Bih-Rong Wei, Thomas D Madsen, R Mark Simpson

bioRxiv· November 2023

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Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma.
Tyler J Peat, Snehal M Gaikwad, Wendy Dubois, Nana Gyabaah-Kessie, Shuling Zhang, R Mark Simpson

Cancer Lett· August 2023

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Pharmacokinetics and tolerability of the dual TORC1/2 inhibitor sapanisertib in combination with the MEK inhibitor trametinib in dogs.
Bih-Rong Wei, Cody J Peer, William J Richardson, Stephen M Hewitt, William D Figg, R Mark Simpson

Front Vet Sci· December 2022

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Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence.
Vanesa C Sanchez, Howard H Yang, Alayna Craig-Lucas, Wendy Dubois, Brandi L Carofino, R Mark Simpson

PLoS Genet· June 2022

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CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development.
Etienne S Melese, Elizabeth Franks, Rachel A Cederberg, Bryant T Harbourne, Rocky Shi, R Mark Simpson

Oncoimmunology· April 2022

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Reconciling Regulation with Scientific Autonomy in Dual-Use Research.
Nicholas G Evans, Michael J Selgelid, Robert Mark Simpson

J Med Philos· February 2022

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Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response.
Ruhul Amin, Anjali Shukla, Jacqueline Jufen Zhu, Sohyoung Kim, Ping Wang, R Mark Simpson

Nat Commun· December 2021

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International Guidelines for Veterinary Tumor Pathology: A Call to Action.
Donald J Meuten, Frances M Moore, Taryn A Donovan, Christof A Bertram, Robert Klopfleisch, R Mark Simpson

Vet Pathol· September 2021

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Efficacy, Tolerability, and Pharmacokinetics of Combined Targeted MEK and Dual mTORC1/2 Inhibition in a Preclinical Model of Mucosal Melanoma.
Bih-Rong Wei, Shelley B Hoover, Cody J Peer, Jennifer E Dwyer, Hibret A Adissu, R Mark Simpson

Mol Cancer Ther· November 2020

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Hypomorphic mTOR Downregulates CDK6 and Delays Thymic Pre-T LBL Tumorigenesis.
Joy M Gary, John K Simmons, Jinfei Xu, Shuling Zhang, Tyler J Peat, R Mark Simpson

Mol Cancer Ther· October 2020

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Inter-Institutional Partnerships to Develop Veterinarian-Investigators through the NIH Comparative Biomedical Scientist Training Program Benefit One Health Goals.
R Mark Simpson, Shelley B Hoover, Barbara J Davis, John Hickerson, Margaret A Miller

J Vet Med Educ· October 2020

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The Outcome of TGFβ Antagonism in Metastatic Breast Cancer Models Reflects a Complex Balance between Tumor-Suppressive and Proprogression Activities of TGFβ.
Yuan Yang, Howard H Yang, Binwu Tang, Alex Man Lai Wu, Kathleen C Flanders, R Mark Simpson

Clin Cancer Res· February 2020

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Agreement in Histological Assessment of Mitotic Activity Between Microscopy and Digital Whole Slide Images Informs Conversion for Clinical Diagnosis.
Bih-Rong Wei, Charles H Halsey, Shelley B Hoover, Munish Puri, Howard H Yang, R Mark Simpson

Acad Pathol· July 2019

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Automated Computational Detection, Quantitation, and Mapping of Mitosis in Whole-Slide Images for Clinically Actionable Surgical Pathology Decision Support.
Munish Puri, Shelley B Hoover, Stephen M Hewitt, Bih-Rong Wei, Hibret Amare Adissu, R Mark Simpson

J Pathol Inform· February 2019

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High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer.
Keith H Jansson, John B Tucker, Lauren E Stahl, John K Simmons, Caitlyn Fuller, R Mark Simpson

Sci Rep· November 2018

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Naturally Occurring Canine Melanoma as a Predictive Comparative Oncology Model for Human Mucosal and Other Triple Wild-Type Melanomas.
Belen Hernandez, Hibret A Adissu, Bih-Rong Wei, Helen T Michael, Glenn Merlino, R Mark Simpson

Int J Mol Sci· January 2018

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cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma.
Yunlong He, Wentao Zhu, Min Hwa Shin, Joy Gary, Chengyu Liu, R Mark Simpson

Stem Cell Reports· June 2017

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Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma.
Bih-Rong Wei, Helen T Michael, Charles H C Halsey, Cody J Peer, Amit Adhikari, R Mark Simpson

Pigment Cell Melanoma Res· November 2016

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Climate change, cooperation and moral bioenhancement.
Toby Handfield, Pei-Hua Huang, Robert Mark Simpson

J Med Ethics· November 2016

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EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models.
Abhilash Venugopalan, Min-Jung Lee, Gang Niu, José Medina-Echeverz, Yusuke Tomita, Robert Mark Simpson

Oncotarget· August 2016

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Dehumanization: its operations and its origins.
Robert Mark Simpson

J Law Biosci· April 2016

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