Publications by authors named "Ronald Viola"

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Development of Efficient Covalent Inactivators of a Fungal Aspartate Semialdehyde Dehydrogenase.
Samantha N Friday, Liezel A Koellner, Spencer W Brown, Christopher N Calbat, Catherine F Curran, Ronald E Viola

Drug Dev Res· May 2025

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Identification of potential pharmacological chaperones that selectively stabilize mutated Aspartoacylases in Canavan disease.
Nitesh Kumar Poddar, Yasanandana S Wijayasinghe, Ronald E Viola

Biochim Biophys Acta Proteins Proteom· November 2024

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A growth-based assay using fluorescent protein emission to screen for S-adenosylmethionine synthetase inhibitors.
Ronald E Viola, Gwenn G Parungao, Robert M Blumenthal

Drug Dev Res· February 2024

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Dual-Acting Peptides Target EZH2 and AR: A New Paradigm for Effective Treatment of Castration-Resistant Prostate Cancer.
Zhengyang Han, Ujjwal Rimal, Prabesh Khatiwada, Jacob Brandman, Jun Zhou, Ronald E Viola

Endocrinology· November 2022

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Design and testing of selective inactivators against an antifungal enzyme target.
Samantha N Friday, Daniel W Cheng, Sebastian G Zagler, Brady S Zanella, Jordan D Dietz, Ronald E Viola

Drug Dev Res· April 2022

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A Comprehensive Biological and Synthetic Perspective on 2-Deoxy-d-Glucose (2-DG), A Sweet Molecule with Therapeutic and Diagnostic Potentials.
Yasanandana S Wijayasinghe, Meenakshi P Bhansali, Maheshkumar R Borkar, Ganesh U Chaturbhuj, Brian S Muntean, Ronald E Viola

J Med Chem· March 2022

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Natural Products: A Rich Source of Antiviral Drug Lead Candidates for the Management of COVID-19.
Yasanandana S Wijayasinghe, Pravin Bhansali, Ronald E Viola, Mohammad A Kamal, Nitesh K Poddar

Curr Pharm Des· October 2021

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Engineering of a critical membrane-anchored enzyme for high solubility and catalytic activity.
Muhammad S Hussain, Qinzhe Wang, Ronald E Viola

Arch Biochem Biophys· May 2021

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Aspartate semialdehyde dehydrogenase inhibition suppresses the growth of the pathogenic fungus Candida albicans.
Gopal P Dahal, Dylan Launder, Katherine M M McKeone, Joseph P Hunter, Heather R Conti, Ronald E Viola

Drug Dev Res· September 2020

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Discovery of Novel Inhibitors of a Critical Brain Enzyme Using a Homology Model and a Deep Convolutional Neural Network.
Adrian Stecula, Muhammad S Hussain, Ronald E Viola

J Med Chem· August 2020

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Development of bisubstrate analog inhibitors of aspartate N-acetyltransferase, a critical brain enzyme.
Vinay Mutthamsetty, Gopal P Dahal, Qinzhe Wang, Ronald E Viola

Chem Biol Drug Des· January 2020

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The ammonia-lyases: enzymes that use a wide range of approaches to catalyze the same type of reaction.
Ronald E Viola

Crit Rev Biochem Mol Biol· December 2019

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Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum.
Jeffrey Ohren, Gwenn G Parungao, Ronald E Viola

Acta Crystallogr F Struct Biol Commun· April 2019

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Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase.
Gopal P Dahal, Ronald E Viola

Biochem Biophys Res Commun· September 2018

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A Fragment Library Screening Approach to Identify Selective Inhibitors against an Essential Fungal Enzyme.
Gopal P Dahal, Ronald E Viola

SLAS Discov· July 2018

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Complementation of a metK-deficient E. coli strain with heterologous AdoMet synthetase genes.
Gwenn G Parungao, Mojun Zhao, Qinzhe Wang, Stephen P Zano, Ronald E Viola

Microbiology (Reading)· December 2017

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Design and optimization of aspartate N-acetyltransferase inhibitors for the potential treatment of Canavan disease.
Bharani Thangavelu, Vinay Mutthamsetty, Qinzhe Wang, Ronald E Viola

Bioorg Med Chem· February 2017

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Structure of a fungal form of aspartate-semialdehyde dehydrogenase from Aspergillus fumigatus.
Gopal P Dahal, Ronald E Viola

Acta Crystallogr F Struct Biol Commun· January 2017

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Effects of Extracellular Polymeric Substance Composition on Bacteria Disinfection by Monochloramine: Application of MALDI-TOF/TOF-MS and Multivariate Analysis.
Kimberly M Coburn, Qinzhe Wang, Dustin Rediske, Ronald E Viola, B Leif Hanson

Environ Sci Technol· September 2016

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Purification and characterization of aspartate N-acetyltransferase: A critical enzyme in brain metabolism.
Qinzhe Wang, Mojun Zhao, Gwenn G Parungao, Ronald E Viola

Protein Expr Purif· March 2016

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Structural Insights into the Tetrameric State of Aspartate-β-semialdehyde Dehydrogenases from Fungal Species.
Qinqin Li, Zhixia Mu, Rong Zhao, Gopal Dahal, Ronald E Viola

Sci Rep· February 2016

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Structure of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans.
Gopal Dahal, Ronald E Viola

Acta Crystallogr F Struct Biol Commun· November 2015

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Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors.
Bharani Thangavelu, Pravin Bhansali, Ronald E Viola

Bioorg Med Chem· October 2015

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A surprising range of modified-methionyl S-adenosylmethionine analogues support bacterial growth.
Mojun Zhao, Yasanandana S Wijayasinghe, Pravin Bhansali, Ronald E Viola, Robert M Blumenthal

Microbiology (Reading)· March 2015

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A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Alexander G Pavlovsky, Bharani Thangavelu, Pravin Bhansali, Ronald E Viola

Acta Crystallogr D Biol Crystallogr· December 2014

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