Publications by authors named "Ruby H-P Law"

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Macrocyclic Inhibitors Targeting the Prime Site of the Fibrinolytic Serine Protease Plasmin.
Simon J A Wiedemeyer, Guojie Wu, Heike Lang-Henkel, James C Whisstock, Ruby H P Law

ChemMedChem· December 2024

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A mechanism for hereditary angioedema caused by a methionine-379-to-lysine substitution in kininogens.
S Kent Dickeson, Sunil Kumar, Mao-Fu Sun, Maxim Litvak, Tracey Z He, Ruby H P Law

Blood· February 2024

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Proteoform-Resolved Profiling of Plasminogen Activation Reveals Novel Abundant Phosphorylation Site and Primary N-Terminal Cleavage Site.
Dario A T Cramer, Victor Yin, Tomislav Caval, Vojtech Franc, Dingyi Yu, Ruby H P Law

Mol Cell Proteomics· January 2024

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Fragment-based and structure-guided discovery of perforin inhibitors.
Jiney Jose, Ruby H P Law, Eleanor W W Leung, Dorothy C C Wai, Hedieh Akhlaghi

Eur J Med Chem· December 2023

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A High-Throughput Small-Angle X-ray Scattering Assay to Determine the Conformational Change of Plasminogen.
Adam J Quek, Nathan P Cowieson, Tom T Caradoc-Davies, Paul J Conroy, James C Whisstock, Ruby H P Law

Int J Mol Sci· September 2023

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The role of NINJ1 protein in programmed cellular destruction.
James C Whisstock, Ruby H P Law

Nature· June 2023

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Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors.
Simon J A Wiedemeyer, Guojie Wu, T L Phuong Pham, Heike Lang-Henkel, Benjamin Perez Urzua, Ruby H P Law

ChemMedChem· March 2023

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Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains.
Aleksandr Shamanaev, Ivan Ivanov, Mao-Fu Sun, Maxim Litvak, Priyanka Srivastava, Ruby H P Law

Blood Adv· May 2022

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A mechanism for hereditary angioedema caused by a lysine 311-to-glutamic acid substitution in plasminogen.
S Kent Dickeson, Sunil Kumar, Mao-Fu Sun, Bassem M Mohammed, Dennis R Phillips, Ruby H P Law

Blood· May 2022

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Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma.
Thomas Kryza, Tashbib Khan, Simon Puttick, Chao Li, Kamil A Sokolowski, Ruby H P Law

Theranostics· May 2021

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Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer.
Brittney S Harrington, Yaowu He, Tashbib Khan, Simon Puttick, Paul J Conroy, Ruby H P Law

Theranostics· April 2021

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Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface.
Milena M Awad, Melanie L Hutton, Adam J Quek, William P Klare, Steven J Mileto, Ruby H P Law

Gastroenterology· October 2020

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Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides.
Andrew M White, Simon J de Veer, Guojie Wu, Peta J Harvey, Kuok Yap, Ruby H P Law

Angew Chem Int Ed Engl· July 2020

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Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.
Yue Yuan, Yetunde A Ayinuola, Damini Singh, Olawole Ayinuola, Jeffrey A Mayfield, Ruby H P Law

J Struct Biol· October 2019

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Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding.
Adam J H Quek, Blake A Mazzitelli, Guojie Wu, Eleanor W W Leung, Tom T Caradoc-Davies, Ruby H P Law

J Mol Biol· September 2019

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The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Siew Siew Pang, Charles Bayly-Jones, Mazdak Radjainia, Bradley A Spicer, Ruby H P Law

Nat Commun· September 2019

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Structural studies of plasmin inhibition.
Guojie Wu, Adam J Quek, Tom T Caradoc-Davies, Sue M Ekkel, Blake Mazzitelli, Ruby H P Law

Biochem Soc Trans· April 2019

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Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.
Guojie Wu, Blake A Mazzitelli, Adam J Quek, Matthew J Veldman, Paul J Conroy, Ruby H P Law

Blood Adv· March 2019

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Characterising the Subsite Specificity of Urokinase-Type Plasminogen Activator and Tissue-Type Plasminogen Activator using a Sequence-Defined Peptide Aldehyde Library.
Choi Yi Li, Simon J de Veer, Ruby H P Law, James C Whisstock, David J Craik

Chembiochem· January 2019

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Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
Joakim E Swedberg, Guojie Wu, Tunjung Mahatmanto, Thomas Durek, Tom T Caradoc-Davies, Ruby H P Law

J Med Chem· January 2019

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A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.
Maiada M Sadek, Nicholas Barlow, Eleanor W W Leung, Billy J Williams-Noonan, Beow Keat Yap, Ruby H P Law

ACS Chem Biol· October 2018

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Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Amelia J Brennan, Ruby H P Law, Paul J Conroy, Tahereh Noori, Natalya Lukoyanova

Cell Death Differ· August 2018

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Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma.
Hsiao P J Voon, Maheshi Udugama, Wendi Lin, Linda Hii, Ruby H P Law

Nat Commun· August 2018

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The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
Bradley A Spicer, Ruby H P Law, Tom T Caradoc-Davies, Sue M Ekkel, Charles Bayly-Jones

Nat Commun· August 2018

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X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.
Ruby H P Law, Guojie Wu, Eleanor W W Leung, Koushi Hidaka, Adam J Quek

Blood Adv· May 2017

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