Publications by authors named "Rui Nobre"

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Exosomes as Emerging Non-Invasive Biomarkers of Cervical Cancer: A Systematic Review and Meta-Analysis.
Fernanda Santos, Francisco A Caramelo, Jorge M P Tomaz, Magda M Santana, Rui J Nobre

Cancers (Basel)· December 2025

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Spinocerebellar ataxia type 3: from pathogenesis to promising therapeutics.
Ana Carolina Silva, Miguel Monteiro Lopes, Diana Duarte Lobo, Carina Henriques, Luís Pereira de Almeida, Rui Jorge Nobre

Trends Mol Med· November 2025

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Differential impact of mutant Ataxin-3 in hindbrain regions: further evidence of white matter loss as a core pathological feature.
Carina Henriques, Marta Silva, António Silva, David Rufino-Ramos, Miguel Monteiro Lopes, Rui Jorge Nobre

Exp Neurol· November 2025

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Targeting under-screened women in cervical cancer: combining self-sampling and human papillomavirus testing with a strategic reminder plan.
Sara da Graça Pereira, Luís Nobre, Marina Ribeiro, Patrícia Carvalho, Ana Morais, Rui Jorge Nobre

Eur J Public Health· October 2025

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Extracellular vesicles-associated AAVs for the treatment of Machado-Joseph disease.
Carina Henriques, Patrícia Albuquerque, David Rufino-Ramos, Miguel M Lopes, Kevin Leandro, Rui Jorge Nobre

Mol Ther· October 2025

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MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress.
Beatriz Rodrigues, Ricardo A Leitão, Mónica Santos, Alexander Trofimov, Mariline Silva, Rui J Nobre

Mol Psychiatry· March 2025

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A systematic screening assay identifies efficient small guide RNAs for CRISPR activation.
Elin Arvidsson, Diana Duarte Lobo, Ermelinda Sabarese, Fabio Duarte, Rui Jorge Nobre

Front Bioeng Biotechnol· January 2025

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Molecular therapy for polyQ disorders: from bench to clinical trials.
João de Sousa-Lourenço, Ana C Silva, Luís Pereira de Almeida, Rui J Nobre

Trends Mol Med· September 2024

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Science around the world.
Meaghan J Griffiths, Rui J Nobre

Trends Mol Med· September 2024

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Viral-based animal models in polyglutamine disorders.
Carina Henriques, Miguel M Lopes, Ana C Silva, Diana D Lobo, Romina Aron Badin, Rui Jorge Nobre

Brain· April 2024

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Isolation of Adeno-associated Viral Vectors Through a Single-step and Semi-automated Heparin Affinity Chromatography Protocol.
Miguel M Lopes, Sara M Lopes, Rafael Baganha, Carina Henriques, Ana C Silva, Rui Jorge Nobre

J Vis Exp· April 2024

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RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation.
Jéssica Lopes-Nunes, Pedro Simões, David Moreira, Kevin Leandro, Rui Jorge Nobre

Int J Biol Macromol· February 2024

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Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3.
David Rufino-Ramos, Patrícia R Albuquerque, Kevin Leandro, Vitor Carmona, Inês M Martins, Rui Jorge Nobre

Mol Ther· May 2023

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Isolation of Extracellular Vesicles from Human Follicular Fluid: Size-Exclusion Chromatography versus Ultracentrifugation.
Maria Soares, Maria M Pinto, Rui Jorge Nobre, Luís Pereira de Almeida, Maria da Graça Rasteiro

Biomolecules· February 2023

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A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification.
Miguel M Lopes, Jacques Paysan, José Rino, Sara M Lopes, Luís Pereira de Almeida, Rui Jorge Nobre

Gene Ther· December 2022

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miRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3.
Rui Jorge Nobre, Diana D Lobo, Carina Henriques, Sonia P Duarte, Sara M Lopes

Nucleic Acid Ther· June 2022

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Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease.
Catarina Oliveira Miranda, Rui Jorge Nobre, Vitor Hugo Paiva, João Valente Duarte, João Castelhano

Acta Neuropathol Commun· March 2022

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Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy.
Adriana Marcelo, Inês T Afonso, Ricardo Afonso-Reis, David V C Brito, Rafael G Costa, Rui J Nobre

Cell Death Dis· November 2021

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Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening.
Sandra Isabel Aguiar, Joana N R Dias, Ana Santos André, Marta Lisete Silva, Diana Martins, Rui Jorge Nobre

Pharmaceutics· October 2021

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Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research.
Laetitia S Gaspar, Magda M Santana, Carina Henriques, Maria M Pinto, Teresa M Ribeiro-Rodrigues, Rui Jorge Nobre

Mol Ther Methods Clin Dev· September 2020

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The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples.
Diana Duarte Lobo, Rui Jorge Nobre, Catarina Oliveira Miranda, Dina Pereira, João Castelhano

Acta Neuropathol Commun· August 2020

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Protocol for the Characterization of the Cytosine-Adenine-Guanine Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies.
Sara M Lopes, Rosário Faro, Miguel M Lopes, Isabel Onofre, Nuno Mendonça, Rui Jorge Nobre

J Mol Diagn· June 2020

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Trehalose alleviates the phenotype of Machado-Joseph disease mouse models.
Magda M Santana, Susana Paixão, Janete Cunha-Santos, Teresa Pereira Silva, Allyson Trevino-Garcia, Rui Jorge Nobre

J Transl Med· April 2020

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Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders.
Ana C Silva, Diana D Lobo, Inês M Martins, Sara M Lopes, Carina Henriques, Rui Jorge Nobre

Brain· February 2020

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Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease.
Catarina Oliveira Miranda, Adriana Marcelo, Teresa Pereira Silva, João Barata, Ana Vasconcelos-Ferreira, Rui Jorge Nobre

Mol Ther· September 2018

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