Publications by authors named "Ryan Mailloux"

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Accumulation of succinate in the blood is a potential early indicator of metabolic dysfunction-associated steatotic liver disease (MASLD).
Olivia Chalifoux, Chloe Dagostino, Meijing Li, Stephanie Trezza, Cathryn Grayson, Ryan J Mailloux

Free Radic Biol Med· December 2025

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The polyphenols phloretin and quercetin are potent horseradish peroxidase (HRP) inhibitors.
Ben Faerman, Olivia Chalifoux, Marek Michalak, Luis B Agellon, Ryan J Mailloux

Biochim Biophys Acta Gen Subj· August 2025

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MitoSNO inhibits mitochondrial hydrogen peroxide generation by α-ketoglutarate dehydrogenase.
Olivia Chalifoux, Samantha Sterman, Ben Faerman, Meijing Li, Stephanie Trezza, Ryan J Mailloux

J Biol Chem· June 2025

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Targeted Redox Regulation α-Ketoglutarate Dehydrogenase Complex for the Treatment of Human Diseases.
Ryan J Mailloux

Cells· April 2025

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Ablating the glutaredoxin-2 (Glrx2) gene protects male mice against non-alcoholic fatty liver disease (NAFLD) by limiting oxidative distress.
Cathryn Grayson, Olivia Chalifoux, Mariana De Sa Tavares Russo, Daina Zofija Avizonis, Samantha Sterman, Ryan J Mailloux

Free Radic Biol Med· November 2024

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Fundamentals of redox regulation in biology.
Helmut Sies, Ryan J Mailloux, Ursula Jakob

Nat Rev Mol Cell Biol· September 2024

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Author Correction: Fundamentals of redox regulation in biology.
Helmut Sies, Ryan J Mailloux, Ursula Jakob

Nat Rev Mol Cell Biol· September 2024

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The emerging importance of the α-keto acid dehydrogenase complexes in serving as intracellular and intercellular signaling platforms for the regulation of metabolism.
Ryan J Mailloux

Redox Biol· June 2024

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Fatty acid oxidation drives mitochondrial hydrogen peroxide production by α-ketoglutarate dehydrogenase.
Cathryn Grayson, Ben Faerman, Olivia Koufos, Ryan J Mailloux

J Biol Chem· April 2024

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Proline and dihydroorotate dehydrogenase promote a hyper-proliferative state and dampen ferroptosis in cancer cells by rewiring mitochondrial redox metabolism.
Ryan J Mailloux

Biochim Biophys Acta Mol Cell Res· February 2024

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Mitochondrial hydrogen peroxide production by pyruvate dehydrogenase and α-ketoglutarate dehydrogenase in oxidative eustress and oxidative distress.
Olivia Chalifoux, Ben Faerman, Ryan J Mailloux

J Biol Chem· December 2023

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Coenzyme Q and nicotinamide nucleotide transhydrogenase: Sentinels for mitochondrial hydrogen peroxide signaling.
Cathryn Grayson, Ryan J Mailloux

Free Radic Biol Med· November 2023

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Mitochondrial function and phenotype are defined by bioenergetics.
Ryan J Mailloux, Jason Treberg, Cathryn Grayson, Luis B Agellon, Helmut Sies

Nat Metab· October 2023

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S-nitroso-glutathione (GSNO) inhibits hydrogen peroxide production by alpha-ketoglutarate dehydrogenase: An investigation into sex and diet effects.
Kevin Wang, Amanda Moore, Cathryn Grayson, Ryan J Mailloux

Free Radic Biol Med· August 2023

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Protein S-glutathionylation and sex dimorphic effects on hydrogen peroxide production by dihydroorotate dehydrogenase in liver mitochondria.
Olivia Koufos, Ryan J Mailloux

Free Radic Biol Med· January 2023

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Regulation of Mitochondrial Hydrogen Peroxide Availability by Protein S-glutathionylation.
Ryan J Mailloux, Cathryn Grayson, Olivia Koufos

Cells· December 2022

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WITHDRAWN: Mitochondria need their sleep: Sleep-wake cycling and the role of redox, bioenergetics, and temperature regulation, involving cysteine-mediated redox signaling, uncoupling proteins, and substrate cycles.
Richard B Richardson, Ryan J Mailloux

Free Radic Biol Med· November 2022

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Conditions Conducive to the Glutathionylation of Complex I Subunit NDUFS1 Augment ROS Production following the Oxidation of Ubiquinone Linked Substrates, Glycerol-3-Phosphate and Proline.
Kevin Wang, Jonathan Hirschenson, Amanda Moore, Ryan J Mailloux

Antioxidants (Basel)· October 2022

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The Uncoupling Proteins: A Systematic Review on the Mechanism Used in the Prevention of Oxidative Stress.
Jonathan Hirschenson, Emiliano Melgar-Bermudez, Ryan J Mailloux

Antioxidants (Basel)· February 2022

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Protein S-glutathionylation decreases superoxide/hydrogen peroxide production xanthine oxidoreductase.
Megan Letourneau, Kevin Wang, Ryan J Mailloux

Free Radic Biol Med· November 2021

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An update on methods and approaches for interrogating mitochondrial reactive oxygen species production.
Ryan J Mailloux

Redox Biol· September 2021

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The glutathionylation agent disulfiram augments superoxide/hydrogen peroxide production when liver mitochondria are oxidizing ubiquinone pool-linked and branched chain amino acid substrates.
Jonathan Hirschenson, Ryan J Mailloux

Free Radic Biol Med· August 2021

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The GLP-1 Receptor Agonist Liraglutide Increases Myocardial Glucose Oxidation Rates via Indirect Mechanisms and Mitigates Experimental Diabetic Cardiomyopathy.
Malak Almutairi, Keshav Gopal, Amanda A Greenwell, Adrian Young, Robert Gill, Ryan J Mailloux

Can J Cardiol· January 2021

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An investigation into the impact of deleting one copy of the gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet.
Robert Gill, Sarah Mallay, Adrian Young, Ryan J Mailloux

Redox Rep· December 2020

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