Publications by authors named "Sean Humphrey"

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Sex-specific phosphoproteome responses to calorie restriction and insulin in skeletal muscle from older rats.
Haiyan Wang, Søren Madsen, Elise J Needham, Sean J Humphrey, Amy Zheng

J Gerontol A Biol Sci Med Sci· November 2025

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IGFBP2 Mediates Human iPSC-Cardiomyocyte Proliferation in a Cellular Contact-Dependent Manner.
Soah Lee, Paul Heinrich, Daniel Lee, Yongwon Kang, Harley R Robinson, Sean J Humphrey

Circ Res· October 2025

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Adipose tissue protein kinase D: regulation of signaling networks and its sex-dependent effects on metabolism.
Mark C Renton, Sean J Humphrey, Tim Connor, Sheree D Martin, Krystal Kemerer

Am J Physiol Endocrinol Metab· July 2025

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Maturation of human cardiac organoids enables complex disease modeling and drug discovery.
Mark W Pocock, Janice D Reid, Harley R Robinson, Natalie Charitakis, James R Krycer, Sean J Humphrey

Nat Cardiovasc Res· July 2025

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Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise.
Jonas M Kristensen, Rasmus Kjøbsted, Trine J Larsen, Christian S Carl, Janne R Hingst, Sean J Humphrey

Nat Metab· December 2024

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Personalized phosphoproteomics of skeletal muscle insulin resistance and exercise links MINDY1 to insulin action.
Elise J Needham, Janne R Hingst, Johan D Onslev, Alexis Diaz-Vegas, Magnus R Leandersson, Sean J Humphrey

Cell Metab· December 2024

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µPhos: a scalable and sensitive platform for high-dimensional phosphoproteomics.
Denys Oliinyk, Andreas Will, Felix R Schneidmadel, Maximilian Böhme, Jenny Rinke, Sean J Humphrey

Mol Syst Biol· August 2024

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The genetic and dietary landscape of the muscle insulin signalling network.
Julian van Gerwen, Stewart W C Masson, Harry B Cutler, Alexis Diaz Vegas, Meg Potter, Sean J Humphrey

Elife· February 2024

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Erratum: Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet.
Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V Carr, Julian Van Gerwen, Sean J Humphrey

iScience· January 2024

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SnapKin: a snapshot deep learning ensemble for kinase-substrate prediction from phosphoproteomics data.
Di Xiao, Michael Lin, Chunlei Liu, Thomas A Geddes, James G Burchfield, Sean J Humphrey

NAR Genom Bioinform· December 2023

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Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment.
Rajeev Rudraraju, Matthew J Gartner, Jessica A Neil, Elizabeth S Stout, Joseph Chen, Sean J Humphrey

Stem Cell Reports· June 2023

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Synergistic Targeting of DNA-PK and KIT Signaling Pathways in KIT Mutant Acute Myeloid Leukemia.
Heather C Murray, Kasey Miller, Joshua S Brzozowski, Richard G S Kahl, Nathan D Smith, Sean J Humphrey

Mol Cell Proteomics· March 2023

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Deep Proteome Profiling of White Adipose Tissue Reveals Marked Conservation and Distinct Features Between Different Anatomical Depots.
Søren Madsen, Marin E Nelson, Vinita Deshpande, Sean J Humphrey, Kristen C Cooke

Mol Cell Proteomics· March 2023

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Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance.
Daniel J Fazakerley, Julian van Gerwen, Kristen C Cooke, Xiaowen Duan, Elise J Needham, Sean J Humphrey

Nat Commun· February 2023

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A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology.
Alexis Diaz-Vegas, Dougall M Norris, Sigrid Jall-Rogg, Kristen C Cooke, Olivia J Conway, Sean J Humphrey

Life Sci Alliance· January 2023

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Targets mapped for almost all human kinase enzymes.
Sean J Humphrey, Elise J Needham

Nature· January 2023

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Global profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa.
David A Skerrett-Byrne, Amanda L Anderson, Elizabeth G Bromfield, Ilana R Bernstein, Jess E Mulhall, Sean J Humphrey

Cell Rep· November 2022

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Parallel use of pluripotent human stem cell lung and heart models provide new insights for treatment of SARS-CoV-2.
Rajeev Rudraraju, Matthew J Gartner, Jessica A Neil, Elizabeth S Stout, Joseph Chen, Sean J Humphrey

bioRxiv· September 2022

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Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate.
Xiaowen Duan, Dougall M Norris, Sean J Humphrey, Pengyi Yang, Kristen C Cooke

Biochem J· June 2022

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Environmental control of Pub1 (NEDD4 family E3 ligase) in is regulated by TORC2 and Gsk3.
Tingting Wang, Philip Woodman, Sean J Humphrey, Janni Petersen

Life Sci Alliance· May 2022

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Personalized phosphoproteomics identifies functional signaling.
Elise J Needham, Janne R Hingst, Benjamin L Parker, Kaitlin R Morrison, Guang Yang, Sean J Humphrey

Nat Biotechnol· April 2022

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Author Correction: Extracellular vesicles released by non-small cell lung cancer cells drive invasion and permeability in non-tumorigenic lung epithelial cells.
Humna Hasan, Ikjot Singh Sohal, Zulaida Soto-Vargas, Anjali M Byappanahalli, Sean E Humphrey

Sci Rep· February 2022

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Extracellular vesicles released by non-small cell lung cancer cells drive invasion and permeability in non-tumorigenic lung epithelial cells.
Humna Hasan, Ikjot Singh Sohal, Zulaida Soto-Vargas, Anjali M Byappanahalli, Sean E Humphrey

Sci Rep· January 2022

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Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet.
Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V Carr, Julian Van Gerwen, Sean J Humphrey

iScience· October 2021

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Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis.
Alison L Kearney, Dougall M Norris, Milad Ghomlaghi, Martin Kin Lok Wong, Sean J Humphrey

Elife· July 2021

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