Publications by authors named "Seongkyu Yoon"

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Characterization of Chinese hamster ovary cell culture feed media precipitate.
Duc Hoang, Shaun Galbraith, Bingyu Kuang, Amy Johnson, Seongkyu Yoon

Biotechnol Prog· September 2021

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AutoML-Driven Soft Sensors for Real-Time Monitoring of Amino Acids in Mammalian Perfusion Cultures.
Sun-Jong Kim, Minouk Lee, Daehwan Kim, Seongkyu Yoon, Dong-Yup Lee

Biotechnol Bioeng· November 2025

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Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing.
Erica A Green, Qiang Fu, Nelson Ndahiro, Thomas M Leibiger, Yongdan Wang, Seongkyu Yoon

Biotechnol Bioeng· July 2025

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Effect of different cell culture media on the production and glycosylation of a monoclonal antibody from a CHO cell line.
Jaeweon Lee, Uriel Ortega-Rodriguez, Chikkathur N Madhavarao, Tongzhong Ju, Thomas O'Connor, Seongkyu Yoon

Cytotechnology· June 2025

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Metabolic Engineering of for Conversion of Waste Cooking Oil into Omega-3 Eicosapentaenoic Acid.
Jiansong Qin, Na Liu, Umer Abid, Sarah M Coleman, Yongdan Wang, Seongkyu Yoon

ACS Eng Au· April 2025

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Interferon inhibitors increase rAAV production in HEK293 cells.
Yongdan Wang, Qiang Fu, Sha Sha, Seongkyu Yoon

J Biotechnol· March 2025

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Regeneration of Spent Culture Media for Sustainable and Continuous mAb Production via Ion Concentration Polarization.
Eric Wynne, Junghyo Yoon, Dohyun Park, Mingyang Cui, Caitlin Morris, Seongkyu Yoon, Jongyoon Han

Biotechnol Bioeng· February 2025

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Considerations Regarding High Oil Density Bioreactor-Scale Fermentations of Yarrowia lipolytica Using CFD Modeling and Experimental Validation.
Sarah M Coleman, Richard J Marx, Morgan K Martinez, Ashli J Silvera, Junwon Park, Seongkyu Yoon

Biotechnol J· December 2024

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Development of a Single Vial Mass Flow Rate Monitor to Assess Pharmaceutical Freeze Drying Heterogeneity.
Tiffany Yu, Richard Marx, Michael Hinds, Nicholas Schott, Emily Gong, Seongkyu Yoon

AAPS PharmSciTech· October 2024

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Soft-sensor model development for CHO growth/production, intracellular metabolite, and glycan predictions.
George Liang, Sha Sha, Zhao Wang, Huolong Liu, Seongkyu Yoon

Front Mol Biosci· October 2024

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Driving towards digital biomanufacturing by CHO genome-scale models.
Seo-Young Park, Dong-Hyuk Choi, Jinsung Song, Meiyappan Lakshmanan, Anne Richelle, Seongkyu Yoon

Trends Biotechnol· September 2024

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Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cells.
Qiang Fu, Yongdan Wang, Jiansong Qin, Dongming Xie, David McNally, Seongkyu Yoon

Appl Microbiol Biotechnol· September 2024

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Separation of full, empty, and partial adeno-associated virus capsids via anion-exchange chromatography with continuous recycling and accumulation.
Yong Suk Lee, Jaeweon Lee, Kun Fang, Gretchen V Gee, Benjamin Rogers, Seongkyu Yoon

J Chromatogr B Analyt Technol Biomed Life Sci· July 2024

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Decoding cellular mechanism of recombinant adeno-associated virus (rAAV) and engineering host-cell factories toward intensified viral vector manufacturing.
Yongdan Wang, Qiang Fu, So Young Park, Yong Suk Lee, Seo-Young Park, Seongkyu Yoon

Biotechnol Adv· March 2024

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Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture.
George Liang, Chikkathur N Madhavarao, Caitlin Morris, Thomas O'Connor, Muhammad Ashraf, Seongkyu Yoon

Appl Microbiol Biotechnol· March 2024

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CFD evaluation of hydrophobic feedstock bench-scale fermenters for efficient high agitation volumetric mass transfer.
Richard Marx, Huolong Liu, Seongkyu Yoon, Dongming Xie

Biotechnol J· February 2024

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Trace metal optimization in CHO cell culture through statistical design of experiments.
Ashli Polanco, George Liang, SoYoung Park, Yongdan Wang, Ryan J Graham, Seongkyu Yoon

Biotechnol Prog· January 2024

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Transcriptomic features reveal molecular signatures associated with recombinant adeno-associated virus production in HEK293 cells.
Yongdan Wang, Qiang Fu, Yong Suk Lee, Sha Sha, Seongkyu Yoon

Biotechnol Prog· November 2023

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Design space determination to optimize DNA complexation and full capsid formation in transient rAAV manufacturing.
Qiang Fu, Yong Suk Lee, Erica A Green, Yongdan Wang, So Young Park, Seongkyu Yoon

Biotechnol Bioeng· November 2023

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Addressing amino acid-derived inhibitory metabolites and enhancing CHO cell culture performance through DOE-guided media modifications.
Pranay Ladiwala, Venkata Gayatri Dhara, Jackson Jenkins, Bingyu Kuang, Duc Hoang, Seongkyu Yoon

Biotechnol Bioeng· September 2023

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Critical challenges and advances in recombinant adeno-associated virus (rAAV) biomanufacturing.
Qiang Fu, Ashli Polanco, Yong Suk Lee, Seongkyu Yoon

Biotechnol Bioeng· September 2023

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Modulation of nutrient precursors for controlling metabolic inhibitors by genome-scale flux balance analysis.
Duc Hoang, Bingyu Kuang, George Liang, Zhao Wang, Seongkyu Yoon

Biotechnol Prog· March 2023

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Generation of reference cell lines, media, and a process platform for CHO cell biomanufacturing.
Lauren T Cordova, Hussain Dahodwala, Kathryn S Elliott, Jongyoun Baik, Daniel C Odenewelder, Seongkyu Yoon

Biotechnol Bioeng· March 2023

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Physicochemical surrogates for in vitro toxicity assessment of liposomal amphotericin B.
Richard Marx, Jaeweon Lee, Yuri Svirkin, Seongkyu Yoon, Nelson Landrau

Int J Pharm· November 2022

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Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity.
Yuri Svirkin, Jaeweon Lee, Richard Marx, Seongkyu Yoon, Nelson Landrau

Asian J Pharm Sci· July 2022

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A Compact Model for Lyophilizer Equipment Capability Estimation.
Petr Kazarin, William Kessler, Emily Gong, Seongkyu Yoon, Huolong Liu

AAPS PharmSciTech· December 2021

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