Publications by authors named "Shaji Chacko"

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Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial.
Premranjan Kumar, Chun Liu, Jean W Hsu, Shaji Chacko, Charles Minard, Farook Jahoor, Rajagopal V Sekhar

Clin Transl Med· March 2021

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Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.
Annika S Axelsson, Emily Tubbs, Brig Mecham, Shaji Chacko, Hannah A Nenonen, Yunzhao Tang, Jed W Fahey, Jonathan M J Derry, Claes B Wollheim, Nils Wierup

June 2017

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Selective agonism of liver and gut FXR prevents cholestasis and intestinal atrophy in parenterally fed neonatal pigs.
Yanjun Jiang, Zhengfeng Fang, Gregory Guthrie, Barbara Stoll, Shaji Chacko

J Lipid Res· November 2025

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Metabolic impact of dietary glycine supplementation in individuals with severe obesity.
Hong Chang Tan, Jean W Hsu, E Shyong Tai, Shaji Chacko, Vieon Wu

Sci Rep· October 2025

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A comprehensive UHPLC-MS/MS and extraction method reveals flavonoid profile and concentration are diverse in spinach ().
Michael P Dzakovich, Elaine A Le, Alvin L Tak, Shaji K Chacko

Front Plant Sci· April 2025

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Chronic β3-AR stimulation activates distinct thermogenic mechanisms in brown and white adipose tissue and improves systemic metabolism in aged mice.
Duraipandy Natarajan, Bhuvana Plakkot, Kritika Tiwari, Shoba Ekambaram, Weidong Wang, Shaji K Chacko

Aging Cell· December 2024

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Selective Agonism of Liver and Gut FXR Prevents Cholestasis and Intestinal Atrophy in Parenterally Fed Neonatal Pigs.
Yanjun Jiang, Zhengfeng Fang, Gregory Guthrie, Barbara Stoll, Shaji Chacko

bioRxiv· September 2024

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The Impact of Bariatric Surgery on Glutathione Synthesis in Individuals with Severe Obesity.
Hong Chang Tan, Jean W Hsu, E Shyong Tai, Shaji Chacko, Jean-Paul Kovalik

Antioxidants (Basel)· August 2024

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The metabolic benefits of thermogenic stimulation are preserved in aging.
Duraipandy Natarajan, Bhuvana Plakkot, Kritika Tiwari, Shoba Ekambaram, Weidong Wang, Shaji K Chacko

bioRxiv· July 2024

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Glycemia and Gluconeogenesis With Metformin and Liraglutide: A Randomized Trial in Youth-onset Type 2 Diabetes.
Katrina B Dietsche, Sheela N Magge, Sydney A Dixon, Faith S Davis, Andrea Krenek, Shaji Chacko

J Clin Endocrinol Metab· April 2024

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The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
Hong Chang Tan, Jean W Hsu, E Shyong Tai, Shaji Chacko, Jean-Paul Kovalik

Front Endocrinol (Lausanne)· April 2024

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Pulsatile Leucine Administration during Continuous Enteral Feeding Enhances Skeletal Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis in a Preterm Piglet Model.
Marko Rudar, Agus Suryawan, Hanh V Nguyen, Shaji K Chacko, Caitlin Vonderohe

J Nutr· February 2024

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Leptin Decreases Gluconeogenesis and Gluconeogenic Substrate Availability in Patients With Lipodystrophy.
Emmanuel Quaye, Shaji Chacko, Megan Startzell, Rebecca J Brown

J Clin Endocrinol Metab· December 2023

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Regulation of skeletal muscle protein synthesis in the preterm pig by intermittent leucine pulses during continuous parenteral feeding.
Marko Rudar, Agus Suryawan, Hanh V Nguyen, Shaji K Chacko, Caitlin Vonderohe

JPEN J Parenter Enteral Nutr· February 2023

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Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans.
Shiqi Zhong, Raphael Chèvre, David Castaño Mayan, Maria Corlianò, Blake J Cochran, Shaji Chacko

J Clin Invest· November 2022

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Glycine Synthesis Is Reduced in Adults With Morbid Obesity and Increases Following Bariatric Surgery.
Hong Chang Tan, Jean W Hsu, E Shyong Tai, Shaji Chacko, Vieon Wu

Front Endocrinol (Lausanne)· June 2022

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Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model.
Alexandra L Gannon, Shaji K Chacko, Inka C Didelija, Juan C Marini, Chellakkan S Blesson

J Vis Exp· March 2022

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Depletion and enrichment of phytosterols in soybean oil lipid emulsions directly associate with serum markers of cholestasis in preterm parenteral nutrition-fed pigs.
Greg Guthrie, Barbara Stoll, Shaji Chacko, Mahmoud Mohammad, Candace Style

JPEN J Parenter Enteral Nutr· January 2022

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Tissue-specific mechanisms of bile acid homeostasis and activation of FXR-FGF19 signaling in preterm and term neonatal pigs.
Caitlin Vonderohe, Greg Guthrie, Barbara Stoll, Shaji Chacko, Harry Dawson

Am J Physiol Gastrointest Liver Physiol· January 2022

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Energy expenditure due to gluconeogenesis in pathological conditions of insulin resistance.
Emmanuel Quaye, Shaji Chacko, Stephanie T Chung, Robert J Brychta, Kong Y Chen

Am J Physiol Endocrinol Metab· December 2021

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Branched-Chain Amino Acid Oxidation Is Elevated in Adults with Morbid Obesity and Decreases Significantly after Sleeve Gastrectomy.
Hong Chang Tan, Jean W Hsu, Jean-Paul Kovalik, Alvin Eng, Weng Hoong Chan, Shaji Chacko

J Nutr· December 2020

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Arginine kinetics are altered in a pilot sample of adolescents and young adults with Barth syndrome.
W Todd Cade, Kathryn L Bohnert, Adam J Bittel, Shaji J Chacko, Bruce W Patterson

Mol Genet Metab Rep· December 2020

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Conditioning with slowly digestible starch diets in mice reduces jejunal α-glucosidase activity and glucogenesis from a digestible starch feeding.
Like Y Hasek, Stephen E Avery, Shaji K Chacko, J Kenneth Fraley, Firoz A Vohra

Nutrition· October 2020

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Metformin improves blood glucose by increasing incretins independent of changes in gluconeogenesis in youth with type 2 diabetes.
Celeste K L Cravalho, Abby G Meyers, Lilian S Mabundo, Amber Courville, Shanna Yang, Shaji Chacko

Diabetologia· October 2020

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Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial.
Premranjan Kumar, Chun Liu, James W Suliburk, Charles G Minard, Raja Muthupillai, Shaji Chacko

Biomedicines· September 2020

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Leptin decreases de novo lipogenesis in patients with lipodystrophy.
Annah P Baykal, Elizabeth J Parks, Robert Shamburek, Majid M Syed-Abdul, Shaji Chacko

JCI Insight· July 2020

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