Publications by authors named "Signe H Nielsen"

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Discovery and Clinical Validation of C1M and C4M as Soluble Biomarkers for Diagnosis, Prognosis, and Symptom Prediction in Psoriatic Disease and Other Inflammatory Arthropathies.
Maria-Angeliki Gkini, Wilson Liao, Kurt de Vlam, Vinod Chandran, Signe Holm Nielsen

J Rheumatol· December 2025

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Crosslinked Fibrin Fragment (X-FIB) as a Biomarker for Endotype Differentiation and Response to Omalizumab Treatment in Chronic Spontaneous Urticaria.
Helena Port, Misbah Noshela Ghazanfar, Ditte Georgina Zhang, Bea Borg, Alexander Egeberg, Signe Holm Nielsen

Allergy· December 2025

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Axial spondyloarthritis, psoriatic arthritis and systemic lupus erythematosus share common molecular features based on post-hoc analysis of serum biomarkers.
Rikke Malmkvist, Anne-Christine Bay-Jensen, Dovile Sinkeviciute, Signe Holm Nielsen, Monica Toft Hannani

Rheumatol Int· October 2025

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Genetic and Environmental Contributions to Serological Biomarkers of Extracellular Matrix Remodeling in Asthma: A Twin Study.
Matej Andelic, Vibeke Backer, Kirsten Ohm Kyvik, Signe Holm Nielsen, Simon Francis Thomsen

Clin Transl Allergy· August 2025

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ECM formation and degradation during fibrosis, repair, and regeneration.
Alejandro E Mayorca-Guiliani, Diana Julie Leeming, Kim Henriksen, Joachim Høg Mortensen, Signe Holm Nielsen

NPJ Metab Health Dis· June 2025

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A novel biomarker of type VII collagen degradation increases in patients with atopic dermatitis and decreases upon treatment with immunosuppressants.
Matej Andelic, Solveig Skovlund Groen, Jesper Grønlund Holm, Alexander Egeberg, Jacob P Thyssen, Valdemar W Nielsen, Signe Holm Nielsen

Eur J Dermatol· April 2025

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Biomarkers of Extracellular Matrix Fragments in Patients with Psoriasis.
Mila Broby Johansen, Signe Holm Nielsen, Helena Port, Tanja Todberg, Marianne Bengtson Løvendorf

Int J Mol Sci· December 2024

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MMP9 and CCL18 associate with chronic urticaria while type I, IV, and VI collagens change with omalizumab treatment.
Ewa A Bartko, Maiken Mellergaard, Solveig S Groen, Signe Holm Nielsen, Jesper Elberling

Allergy· September 2024

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Evaluating the inhibition of IL-17A and TNFα in a cartilage explant model cultured with Th17-derived cytokines.
Solveig Skovlund Groen, Anne-Christine Bay-Jensen, Christian S Thudium, Morten H Dziegiel, Marie Skougaard, Signe Holm Nielsen

J Transl Autoimmun· June 2024

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Biomarkers of systemic inflammation are associated with disease severity and metabolic syndrome in patients with hidradenitis suppurativa.
Nikolaj Holgersen, Valdemar Wendelboe Nielsen, Nana Aviaaja Lippert Rosenø, Jacob P Thyssen, Alexander Egeberg, Signe Holm Nielsen

JAAD Int· June 2024

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Investigating protease-mediated peptides of inflammation and tissue remodeling as biomarkers associated with flares in psoriatic arthritis.
Solveig Skovlund Groen, Signe Holm Nielsen, Anne Christine Bay-Jensen, Mozhgan Rasti, Darshini Ganatra

Arthritis Res Ther· May 2024

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Identification of patient endotypes and adalimumab treatment responders in axial spondyloarthritis using blood-derived extracellular matrix biomarkers.
Helena Port, Frederik Christiansen, Signe Holm Nielsen, Peder Frederiksen, Anne-C Bay-Jensen

RMD Open· January 2024

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Collagen turnover is associated with cardiovascular autonomic and peripheral neuropathy in type 1 diabetes: novel pathophysiological mechanism?
Christian S Hansen, Daniel G K Rasmussen, Tine W Hansen, Signe Holm Nielsen, Simone Theilade

Cardiovasc Diabetol· June 2023

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Marker for kidney fibrosis is associated with inflammation and deterioration of kidney function in people with type 2 diabetes and microalbuminuria.
Christina Gjerlev Poulsen, Daniel G K Rasmussen, Federica Genovese, Tine W Hansen, Signe Holm Nielsen

PLoS One· March 2023

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Novel Biomarker of Collagen Degradation Can Identify Patients Affected With Both Axial Spondyloarthritis and Crohn Disease.
Signe Holm Nielsen, Andrew Stahly, Emilie H Regner, Anne-Christine Bay-Jensen, Morten A Karsdal

J Rheumatol· December 2022

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Baseline serum levels of cross-linked carboxy-terminal telopeptide of type I collagen predict abatacept treatment response in methotrexate-naive, anticitrullinated protein antibody-positive patients with early rheumatoid arthritis.
Chun Wu, Yanhua Hu, Peter Schafer, Sean E Connolly, Robert Wong, Signe Holm Nielsen

RMD Open· December 2022

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Collagen Turnover Biomarkers Associate with Active Psoriatic Arthritis and Decrease with Guselkumab Treatment in a Phase 3 Clinical Trial (DISCOVER-2).
Georg Schett, Matthew J Loza, Arumugam Palanichamy, Oliver FitzGerald, Christopher Ritchlin, Signe Holm Nielsen

Rheumatol Ther· August 2022

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Publisher Correction to: Collagen Turnover Biomarkers Associate with Active Psoriatic Arthritis and Decrease with Guselkumab Treatment in a Phase 3 Clinical Trial (DISCOVER-2).
Georg Schett, Matthew J Loza, Arumugam Palanichamy, Oliver FitzGerald, Christopher Ritchlin, Signe Holm Nielsen

Rheumatol Ther· August 2022

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Increased proteolytic cleavage of osteoglycin is associated with a stable plaque phenotype and lower risk of cardiovascular events.
Dania Al-Sharify, Signe Holm Nielsen, Frank Matthes, Christoffer Tengryd, Jiangming Sun

Atherosclerosis· August 2022

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Are fatty acids associated with disease activity and biomarkers in patients with psoriatic arthritis? Data from a multicenter clinical trial.
Salome Kristensen, Signe Holm Nielsen, Erik Berg Schmidt, Anne Christine Bay-Jensen, Morten A Karsdal

Rheumatol Int· June 2022

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Extracellular matrix protein turnover markers are associated with axial spondyloarthritis-a comparison with postpartum women and other non-axial spondyloarthritis controls with or without back pain.
Helena Port, Signe Holm Nielsen, Sofie Falkenløve Madsen, Anne-Christine Bay-Jensen, Morten Karsdal

Arthritis Res Ther· June 2022

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The experiences of community-dwelling individuals with newly diagnosed type-2 diabetes in using patient-reported outcomes in a municipal setting.
Jeppe Eriksen, Ann Bygholm, Signe Hudtloff Nielsen, Pernille Bertelsen

Digit Health· March 2022

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A serological type II collagen neoepitope biomarker reflects cartilage breakdown in patients with osteoarthritis.
Solveig Skovlund Groen, Dovile Sinkeviciute, Anne-Christine Bay-Jensen, Christian S Thudium, Morten A Karsdal, Lars Arendt-Nielsen, Signe Holm Nielsen

Osteoarthr Cartil Open· December 2021

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Biomarkers of extracellular matrix formation are associated with acute-on-chronic liver failure.
Annarein J C Kerbert, Saurabh Gupta, Eman Alabsawy, Iwona Dobler, Ida Lønsmann, Signe Holm Nielsen, Mette J Nielsen

JHEP Rep· December 2021

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Endotrophin, a pro-peptide of Type VI collagen, is a biomarker of survival in cirrhotic patients with hepatocellular carcinoma.
Diana Julie Leeming, Signe Holm Nielsen, Roslyn Vongsuvanh, Pruthviraj Uchila, Mette Juul Nielsen

Hepat Oncol· December 2020

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