Publications by authors named "Simon Draper"

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Evaluating the potential of cross-species neutralization of anti-PfCyRPA and anti-PfRIPR Monoclonal Antibodies.
Noemi Guerra, Kelly A Hagadorn, Megha Nair, Laty Gaye Thiam, Barnabas G Williams, Simon J Draper

bioRxiv· November 2025

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Diagnosis of Plasmodium falciparum malaria at very low parasitaemias using a commercially available LAMP assay and RDT.
Ruth O Payne, Nick J Edwards, Yrene Themistocleous, Sarah E Silk, Jordan R Barrett, Simon J Draper

Trans R Soc Trop Med Hyg· October 2025

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Development of clinical immunity to Plasmodium vivax following repeat controlled human malaria infection.
Mimi M Hou, Adam C Harding, Natalie M Barber, Prasun Kundu, Florian A Bach, Simon J Draper

Nat Commun· September 2025

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Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection.
Diana Muñoz Sandoval, Florian A Bach, Alasdair Ivens, Adam C Harding, Natasha L Smith, Simon J Draper

J Exp Med· July 2025

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Safety and efficacy of the blood-stage malaria vaccine RH5.1/Matrix-M in Burkina Faso: interim results of a double-blind, randomised, controlled, phase 2b trial in children.
Hamtandi M Natama, Jo Salkeld, Athanase Somé, Seyi Soremekun, Salou Diallo, Simon J Draper

Lancet Infect Dis· May 2025

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Synergistic blockade of TIGIT and PD-L1 increases type-1 inflammation and improves parasite control during murine blood-stage non-lethal infection.
Rebecca S Dookie, Ana Villegas-Mendez, Antonn Cheeseman, Adam P Jones, Ruben Barroso, Simon J Draper

Infect Immun· November 2024

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Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial.
Sarah E Silk, Wilmina F Kalinga, Jo Salkeld, Ivanny M Mtaka, Saumu Ahmed, Simon J Draper

Lancet Infect Dis· October 2024

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Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5.
Thomas E Harrison, Nawsad Alam, Brendan Farrell, Doris Quinkert, Amelia M Lias, Simon J Draper

EMBO Mol Med· October 2024

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Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against P. falciparum clinical isolates.
Laty G Thiam, Kirsty McHugh, Aboubacar Ba, Rebecca Li, Yicheng Guo, Simon J Draper

NPJ Vaccines· October 2024

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Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype.
Jordan R Barrett, Dimitra Pipini, Nathan D Wright, Andrew J R Cooper, Giacomo Gorini, Simon J Draper

Cell· September 2024

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Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5.
Lawrence T Wang, Andrew J R Cooper, Brendan Farrell, Kazutoyo Miura, Ababacar Diouf, Simon J Draper

Cell· September 2024

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Plug and play virus-like particles for the generation of anti-toxin antibodies.
Rebecca J Edge, Amy E Marriott, Emma L Stars, Rohit N Patel, Mark C Wilkinson, Simon J Draper

Toxicon X· September 2024

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Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies.
Lloyd D W King, David Pulido, Jordan R Barrett, Hannah Davies, Doris Quinkert, Simon J Draper

Cell Rep Med· July 2024

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Evaluation of the precision of the Plasmodium knowlesi growth inhibition assay for Plasmodium vivax Duffy-binding protein-based malaria vaccine development.
Jonas E Mertens, Cassandra A Rigby, Martino Bardelli, Doris Quinkert, Mimi M Hou, Simon J Draper

Vaccine· June 2024

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Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex.
Barnabas G Williams, Lloyd D W King, David Pulido, Doris Quinkert, Amelia M Lias, Simon J Draper

Nat Commun· June 2024

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A broadly-neutralizing antibody against glycoprotein that potentiates the breadth and neutralization potency of other antibodies.
Francesca R Donnellan, Vamseedhar Rayaprolu, Pramila Rijal, Victoria O'Dowd, Amar Parvate, Simon J Draper

bioRxiv· June 2024

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Analyses of human vaccine-specific circulating and bone marrow-resident B cell populations reveal benefit of delayed vaccine booster dosing with blood-stage malaria antigens.
Jordan R Barrett, Sarah E Silk, Catherine G Mkindi, Karolina M Kwiatkowska, Mimi M Hou, Simon J Draper

Front Immunol· February 2024

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The PfRCR complex bridges malaria parasite and erythrocyte during invasion.
Brendan Farrell, Nawsad Alam, Melissa N Hart, Abhishek Jamwal, Robert J Ragotte, Simon J Draper

Nature· January 2024

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PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial.
Francisco J Martinez, Michael White, Micheline Guillotte-Blisnick, Christèle Huon, Alix Boucharlat, Simon J Draper

NPJ Vaccines· January 2024

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Human monoclonal antibodies inhibit invasion of transgenic Plasmodium knowlesi expressing Plasmodium vivax Duffy binding protein.
Quentin D Watson, Lenore L Carias, Alyssa Malachin, Karli R Redinger, Jürgen Bosch, Simon J Draper

Malar J· December 2023

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A systematic analysis of the human immune response to Plasmodium vivax.
Florian A Bach, Diana Muñoz Sandoval, Michalina Mazurczyk, Yrene Themistocleous, Thomas A Rawlinson, Simon J Draper

J Clin Invest· October 2023

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Erythrocyte invasion-neutralising antibodies prevent RH5 from binding to basigin-containing membrane protein complexes.
Abhishek Jamwal, Cristina F Constantin, Stephan Hirschi, Sebastian Henrich, Wolfgang Bildl, Simon J Draper

Elife· October 2023

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Cellular iron governs the host response to malaria.
Sarah K Wideman, Joe N Frost, Felix C Richter, Caitlin Naylor, José M Lopes, Simon J Draper

PLoS Pathog· October 2023

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Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination.
Elena Mitsi, Mariana O Diniz, Jesús Reiné, Andrea M Collins, Ryan E Robinson, Simon J Draper

Nat Commun· October 2023

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The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites.
Greta E Weiss, Robert J Ragotte, Doris Quinkert, Amelia M Lias, Madeline G Dans, Simon J Draper

PLoS Pathog· September 2023

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