Publications by authors named "Simon M Lee"

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Inhibitory Activity of Calcium and Sodium Ion Channels of Neurotoxic V-Shape Helical Peptide Analogs and Their Neuroprotective Effect In Vitro.
Ariane Teixeira Dos Santos, Victoria Jiménez Carretero, Jorge Hernández Campano, Ricardo de Pascual, Nan Xu, Simon Ming-Yuen Lee

Pharmaceuticals (Basel)· November 2025

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A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R.
Qian Chen, Congshuang Deng, Xiaoshan Huang, Aili Wang, Nan Xu, Simon Ming-Yuen Lee

Arch Toxicol· September 2025

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Editorial for the Special Issue "Pharmacological Activities and Mechanisms of Action of Natural Products".
Shining Loo, Antony Kam, Chunyue Du, Simon Ming-Yuen Lee

Curr Issues Mol Biol· September 2025

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A TRPV1 agonist from the transcriptome profiling of Dipsastraea rotumana inhibits neuroinflammation in vivo through the NF-κB and MAPK pathways.
Hanbin Chen, Nan Xu, Hiotong Kam, Chen Zhao, Qian Chen, Simon Ming-Yuen Lee

Pharmacol Res· August 2025

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Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models.
Hanbin Chen, Guanghong Li, Lin Deng, Shuli Li, Songqiang Huang, Simon Ming-Yuen Lee

Biol Res· July 2025

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Identification and evaluation of a pinocembrin analog as a TRPV1 inhibitor with analgesic properties in murine pain models.
Hanbin Chen, Guanghong Li, Lin Deng, Nan Xu, Simon Ming-Yuen Lee

Front Pharmacol· June 2025

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Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis.
Yulin He, Guiyi Gong, Geovani Quijas, Simon Ming-Yuen Lee, Ratan K Chaudhuri

FEBS Open Bio· May 2025

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Dehydroervatamine as a promising novel TREM2 agonist, attenuates neuroinflammation.
Lin Li, Nan Xu, Yulin He, Mingsui Tang, Binrui Yang, Simon Ming-Yuen Lee

Neurotherapeutics· March 2025

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The amphipod genome reveals population dynamics and adaptations to hadal environment.
Haibin Zhang, Shuai Sun, Jun Liu, Qunfei Guo, Liang Meng, Simon Ming-Yuen Lee

Cell· March 2025

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Applied machine learning in intelligent systems: knowledge graph-enhanced ophthalmic contrastive learning with "clinical profile" prompts.
Mini Han Wang, Jiazheng Cui, Simon Ming-Yuen Lee, Zhiyuan Lin, Peijin Zeng

Front Artif Intell· March 2025

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Zebrafish as a Visible Neuroinflammation Model for Evaluating the Anti-Inflammation Effect of Curcumin-Loaded Ferritin Nanoparticles.
Jiamao Chen, Haidong Zha, Meng Xu, Shuli Li, Yunfeng Han, Simon Ming-Yuen Lee

ACS Appl Mater Interfaces· January 2025

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Discovery of potent LRRK2 inhibitors by ensemble virtual screening strategy and bioactivity evaluation.
Xiaoqing Gong, Shuli Li, Junli Huang, Shuoyan Tan, Qianqian Zhang, Simon Ming-Yuen Lee

Eur J Med Chem· December 2024

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Oxyphylla A exerts antiparkinsonian effects by ameliorating 6-OHDA-induced mitochondrial dysfunction and dyskinesia in vitro and in vivo.
Min Shao, Chen Zhao, Zhijian Pan, Xuanjun Yang, Cheng Gao, Simon Ming-Yuen Lee

Chem Biol Interact· November 2024

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Taohong Siwu decoction enhances the chemotherapeutic efficacy of doxorubicin by promoting tumor vascular normalization.
Yanfen Cheng, Jingjing Li, Xi Feng, Yihan Wu, Xiaoping Wu, Simon Ming-Yuen Lee

Phytomedicine· November 2024

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Submerged macrophyte restoration enhanced microbial carbon utilization in shallow lakes.
Yao Guo, Songsong Gu, Andrew J Tanentzap, Pei Wang, Qianzheng Li, Simon Ming-Yuen Lee

Sci Total Environ· July 2024

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Protective effects of Amauroderma rugosum on dextran sulfate sodium-induced ulcerative colitis through the regulation of macrophage polarization and suppression of oxidative stress.
Jingjing Li, Xi Luo, Polly Ho-Ting Shiu, Yanfen Cheng, Xin Nie, Simon Ming-Yuen Lee

Biomed Pharmacother· July 2024

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Gamma-type immunoglobulin enhances phagocytosis of amyloid-beta fibrils by microglia.
Tian Zhou, Yue Zhong, Shoujun Yu, Ruibing Sun, Zhenwei Zhang, Simon Ming-Yuen Lee

Neural Regen Res· July 2024

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Characterization of a polysaccharide from Amauroderma rugosum and its proangiogenic activities in vitro and in vivo.
Xin Nie, Jingjing Li, Yanfen Cheng, Panthakarn Rangsinth, Xiaoping Wu, Simon Ming-Yuen Lee

Int J Biol Macromol· June 2024

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A new invertebrate NPY-like polypeptide, ZoaNPY, from the Zoanthus sociatus, as a novel ligand of human NPY Y2 receptor rescues vascular insufficiency via PLC/PKC and Src- FAK-dependent signaling pathways.
Qian Chen, Nan Xu, Chen Zhao, Yulin He, Sandy Hio Tong Kam, Simon Ming-Yuen Lee

Pharmacol Res· May 2024

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A natural small molecule aspidosperma-type alkaloid, hecubine, as a new TREM2 activator for alleviating lipopolysaccharide-induced neuroinflammation in vitro and in vivo.
Lin Li, Yu-Lin He, Nan Xu, Xiu-Fen Wang, Bing Song, Simon Ming-Yuen Lee

Redox Biol· April 2024

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Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin-Proteasome System Activation.
Baojian Guo, Chengyou Zheng, Jie Cao, Xiaoling Qiu, Fangcheng Luo, Simon Mingyuan Lee

Neuromolecular Med· April 2024

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J24335 exerts neuroprotective effects against 6-hydroxydopamine-induced lesions in PC12 cells and mice.
Zhijian Pan, Min Shao, Chen Zhao, Xuanjun Yang, Haitao Li, Simon Ming-Yuen Lee

Eur J Pharm Sci· March 2024

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Anti-metastatic effects of AGS-30 on breast cancer through the inhibition of M2-like macrophage polarization.
Jingjing Li, Zhuyun Liu, Xiaoping Wu, Simon Ming-Yuen Lee, Sai-Wang Seto

Biomed Pharmacother· March 2024

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Structure and activity relationship analysis of xanthones from mangosteen: Identifying garcinone E as a potent dual EGFR and VEGFR2 inhibitor.
Jingjing Li, Xin Nie, Panthakarn Rangsinth, Xiaoping Wu, Chengwen Zheng, Simon Ming-Yuen Lee

Phytomedicine· January 2024

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Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome.
Zhijian Pan, Chao-Wu Yu, Chen Zhao, Min Shao, Xuanjun Yang, Simon Ming-Yuen Lee

Toxicol Appl Pharmacol· December 2023

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