Publications by authors named "Simona Rapposelli"

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Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications.
Javad Sharifi-Rad, Youssef El Rayess, Alain Abi Rizk, Carmen Sadaka, Raviella Zgheib, Wissam Zam, Simona Sestito, Simona Rapposelli, Katarzyna Neffe-Skocińska, Dorota Zielińska

Front Pharmacol· September 2020

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Efficacy of memantine prodrug microemulsion in a Preclinical model of tendinopathy.
Giulia Vanti, Laura Micheli, Lorenzo Di Cesare Mannelli, Clementina Manera, Simona Sestito, Simona Rapposelli

Int J Pharm· August 2025

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Novel Thyroid Hormone Receptor-β Agonist TG68 Exerts Anti-Inflammatory, Lipid-Lowering and Anxiolytic Effects in a High-Fat Diet (HFD) Mouse Model of Obesity.
Beatrice Polini, Caterina Ricardi, Francesca Di Lupo, Massimiliano Runfola, Andrea Bacci, Simona Rapposelli

Cells· April 2025

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NAPE-PLD is target of thiazide diuretics.
Sara Chiarugi, Francesco Margheriti, Valentina De Lorenzi, Elisa Martino, Eleonora Germana Margheritis, Simona Rapposelli

Cell Chem Biol· March 2025

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Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules.
Simona Sestito, Italo Cirone, Simona Sagona, Massimiliano Runfola, Lorenzo Raffellini, Simona Rapposelli

Eur J Med Chem· February 2025

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Novel Orthosteric/Allosteric Ligands of Cannabinoid Receptors: An Unexpected Pharmacological Profile.
Rebecca Ferrisi, Beatrice Polini, Anna Maria Smolyakova, Chiara Migone, Gaia Giammattei, Simona Rapposelli

J Med Chem· January 2025

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Characterization and Otoprotective Effects of Polysaccharides from .
Matteo Banti, Mercedes Garcia-Gil, Lorenzo Guidotti, Graziano Di Giuseppe, Simona Rapposelli

Molecules· January 2025

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Anticancer potential of decursin, decursinol angelate, and decursinol from Nakai: A comprehensive review and future therapeutic prospects.
Simona Sestito, Roberta Ibba, Federico Riu, Sara Carpi, Antonio Carta, Simona Rapposelli

Food Sci Nutr· October 2024

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Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model.
Maria Marchese, Sara Bernardi, Asahi Ogi, Rosario Licitra, Giada Silvi, Simona Rapposelli

Neurobiol Dis· July 2024

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Synthetic Thyroid Hormone Receptor-β Agonists Promote Oligodendrocyte Precursor Cell Differentiation in the Presence of Inflammatory Challenges.
Vito Antonio Baldassarro, Corinne Quadalti, Massimiliano Runfola, Clementina Manera, Simona Rapposelli

Pharmaceuticals (Basel)· August 2023

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New Synthetic Methodology for Drug-like Molecules.
Graeme Barker, Simona Rapposelli

Molecules· July 2023

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Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis.
Andrea Caddeo, Marina Serra, Francesca Sedda, Andrea Bacci, Clementina Manera, Simona Rapposelli

Front Oncol· February 2023

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New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2.
Rebecca Ferrisi, Beatrice Polini, Caterina Ricardi, Francesca Gado, Kawthar A Mohamed, Simona Rapposelli

Int J Mol Sci· January 2023

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Multi-Target Mechanisms of Phytochemicals in Alzheimer's Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation.
Javad Sharifi-Rad, Simona Rapposelli, Simona Sestito, Jesús Herrera-Bravo, Alejandra Arancibia-Diaz

J Pers Med· September 2022

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Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CBR).
Rebecca Ferrisi, Francesca Gado, Beatrice Polini, Caterina Ricardi, Kawthar A Mohamed, Simona Rapposelli

Front Chem· September 2022

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Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands.
Francesca Gado, Rebecca Ferrisi, Beatrice Polini, Kawthar A Mohamed, Caterina Ricardi, Simona Rapposelli

J Med Chem· July 2022

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Editorial: New insights into the mechanisms of resistance to anti-cancer drugs.
Francesco Bertoni, Simona Rapposelli

Front Oncol· July 2022

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Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells.
Francesca Gado, Rebecca Ferrisi, Sarah Di Somma, Fabiana Napolitano, Kawthar A Mohamed, Simona Rapposelli

Molecules· May 2022

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Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids.
Andrea Bacci, Francesca Corsi, Massimiliano Runfola, Simona Sestito, Ilaria Piano, Simona Rapposelli

Pharmaceuticals (Basel)· May 2022

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Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on Pharmacological Effects and Bioavailability Traits.
Yasaman Taheri, Javad Sharifi-Rad, Gizem Antika, Yakup Berkay Yılmaz, Tugba Boyunegmez Tumer, Simona Rapposelli

Oxid Med Cell Longev· January 2022

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Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile.
Simona Sestito, Andrea Bacci, Sara Chiarugi, Massimiliano Runfola, Francesca Gado, Simona Rapposelli

Eur J Med Chem· December 2021

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TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD.
Andrea Caddeo, Marta Anna Kowalik, Marina Serra, Massimiliano Runfola, Andrea Bacci, Simona Rapposelli

Int J Mol Sci· December 2021

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Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease.
Massimiliano Runfola, Michele Perni, Xiaoting Yang, Maria Marchese, Andrea Bacci, Simona Rapposelli

Pharmaceuticals (Basel)· December 2021

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Editorial: Protein-Protein Interactions: Drug Discovery for the Future.
Simona Rapposelli, Eugenio Gaudio, Fabio Bertozzi, Sheraz Gul

Front Chem· November 2021

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Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment.
Javad Sharifi-Rad, Cristina Quispe, Monica Butnariu, Lia Sanda Rotariu, Oksana Sytar, Simona Rapposelli

Cancer Cell Int· June 2021

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Diphenyl-Methane Based Thyromimetic Inhibitors for Transthyretin Amyloidosis.
Bokyung Kim, Young Ho Ko, Massimiliano Runfola, Simona Rapposelli, Gabriella Ortore

Int J Mol Sci· March 2021

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