Publications by authors named "Stevan Tofovic"

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Purine Nucleoside Phosphorylase Inhibition Rebalances Purine Metabolism and Attenuates Organ Damage in Sickle Cell Mice.
Adekunle Emmanuel Alagbe, Lynda Little-Ihrig, Stephanie M Mutchler, Edwin K Jackson, Enrico M Novelli, Stevan P Tofovic

J Cell Mol Med· December 2025

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8-Aminopurines: A Promising New Direction for Purine-Based Therapeutics.
Edwin K Jackson, Stevan P Tofovic, Yuanyuan Chen, Lori A Birder

Hypertension· December 2024

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8-Aminoguanine and its actions in the metabolic syndrome.
Edwin K Jackson, Delbert G Gillespie, Zaichuan Mi, Lori A Birder, Stevan P Tofovic

Sci Rep· September 2024

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8-Aminopurines in the Cardiovascular and Renal Systems and Beyond.
Edwin K Jackson, Stevan P Tofovic, Yuanyuan Chen, Lori A Birder

Hypertension· November 2023

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Dimethyl Sulfoxide Induces Hemolysis and Pulmonary Hypertension.
Stevan P Tofovic, Victor P Bilan, Olga Rafikova, Frank Schneider, Enrico M Novelli

Pril (Makedon Akad Nauk Umet Odd Med Nauki)· November 2022

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Reversal of Right Ventricular Hypertrophy and Dysfunction by Prostacyclin in a Rat Model of Severe Pulmonary Arterial Hypertension.
Rebecca R Vanderpool, Anastasia Gorelova, Yiran Ma, Mohammad Alhamaydeh, Jeffrey Baust, Stevan P Tofovic

Int J Mol Sci· May 2022

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Relaxin Inhibits Ventricular Arrhythmia and Asystole in Rats With Pulmonary Arterial Hypertension.
Brian Martin, Rebecca R Vanderpool, Brian L Henry, Joshua B Palma, Beth Gabris, Stevan P Tofovic

Front Cardiovasc Med· July 2021

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2-Methoxyestradiol Attenuates the Development and Retards the Progression of Hypoxia-And Alpha-Naphthylthiourea-Induced Pulmonary Hypertension.
Stevan P Tofovic, Xinchen Zhang, Tom J Jones, Gordana Petruševska

Pril (Makedon Akad Nauk Umet Odd Med Nauki)· April 2021

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Long-Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats.
Edwin K Jackson, Zaichuan Mi, Delbert G Gillespie, Dongmei Cheng, Stevan P Tofovic

J Am Heart Assoc· March 2021

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Complex III Inhibition-Induced Pulmonary Hypertension Affects the Mitochondrial Proteomic Landscape.
Joel James, Mathews Valuparampil Varghese, Mikhail Vasilyev, Paul R Langlais, Stevan P Tofovic

Int J Mol Sci· August 2020

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DPP4 Inhibition, NPY, PYY, SDF-1, and a Hypertensive Genetic Background Conspire to Augment Cell Proliferation and Collagen Production: Effects That Are Abolished by Low Concentrations of 2-Methoxyestradiol.
Edwin K Jackson, Delbert G Gillespie, Stevan P Tofovic

J Pharmacol Exp Ther· April 2020

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Estradiol Metabolism: Crossroads in Pulmonary Arterial Hypertension.
Stevan P Tofovic, Edwin K Jackson

Int J Mol Sci· December 2019

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Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension.
Ruslan Rafikov, Joel James, Nolan McClain, Stevan P Tofovic, Olga Rafikova

Antioxidants (Basel)· May 2019

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2-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury.
Eman Salah, Sheldon I Bastacky, Edwin K Jackson, Stevan P Tofovic

J Cardiovasc Pharmacol· March 2019

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Metformin Therapy for Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction versus Pulmonary Arterial Hypertension.
Dmitry A Goncharov, Elena A Goncharova, Stevan P Tofovic, Jian Hu, Jeff J Baust

Am J Respir Crit Care Med· September 2018

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Experimental intravascular hemolysis induces hemodynamic and pathological pulmonary hypertension: association with accelerated purine metabolism.
Victor P Bilan, Frank Schneider, Enrico M Novelli, Eric E Kelley, Sruti Shiva, Stevan P Tofovic

Pulm Circ· July 2018

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Captopril Attenuates Cardiovascular and Renal Disease in a Rat Model of Heart Failure With Preserved Ejection Fraction.
Eman M Salah, Sheldon I Bastacky, Edwin K Jackson, Stevan P Tofovic

J Cardiovasc Pharmacol· April 2018

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Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung.
Olga Rafikova, Anup Srivastava, Ankit A Desai, Ruslan Rafikov, Stevan P Tofovic

Respir Res· April 2018

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Nitrite Prevents Right Ventricular Failure and Remodeling Induced by Pulmonary Artery Banding.
Jian Hu, Maryam Sharifi-Sanjani, Stevan P Tofovic

J Cardiovasc Pharmacol· February 2017

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Estrogens in Men: Another Layer of Complexity of Estradiol Metabolism in Pulmonary Hypertension.
Stevan P Tofovic, Edwin K Jackson

Am J Respir Crit Care Med· May 2016

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Dual A1/A2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction.
Stevan P Tofovic, Eman M Salah, Glenn J Smits, Eric T Whalley, Barry Ticho

J Pharmacol Exp Ther· February 2016

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SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction.
Yen-Chun Lai, Diana M Tabima, John J Dube, Kara S Hughan, Rebecca R Vanderpool, Stevan P Tofovic

Circulation· February 2016

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Effect of dipeptidyl peptidase 4 inhibition on arterial blood pressure is context dependent.
Edwin K Jackson, Zaichuan Mi, Stevan P Tofovic, Delbert G Gillespie

Hypertension· January 2015

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Complexities of oestradiol pharmacology in pulmonary arterial hypertension.
Stevan P Tofovic, Edwin K Jackson

Eur Respir J· June 2013

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Gender, sex hormones and pulmonary hypertension.
Eric D Austin, Tim Lahm, James West, Stevan P Tofovic, Anne Katrine Johansen

Pulm Circ· April 2013

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