Publications by authors named "Steven M Cramer"

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E
Elucidating the Interplay Between Resin Media, Feed Constituents, and Process Conditions in AAV Affinity Column Fouling With Confocal Microscopy.
Harshal Soni, Sergey Pryshchep, Thomas F Johnson, Steven M Cramer

Biotechnol Bioeng· December 2025

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In silico mediated development of orthogonally selective mAb downstream processes for the removal of process-related impurities.
Dongyoun Jang, Mario A Gutierrez-Diaz, Scott H Altern, Hendri Tjandra, Steven M Cramer

Biotechnol Prog· December 2025

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Coupling high-throughput and modeling approaches to streamline early-stage process development for biologics.
John P Welsh, Scott H Altern, Jessica Y Lyall, Sean Burgess, Michael A Rauscher, Steven M Cramer

Biotechnol Prog· June 2025

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Evaluation of prototype multimodal resins using chromatographic separability.
Eric Denbaum, Mario A Gutierrez Diaz, Scott H Altern, Chris Belisle, Mark A Snyder, Steven M Cramer

J Chromatogr A· March 2025

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High-throughput in silico workflow for optimization and characterization of multimodal chromatographic processes.
Scott H Altern, Jessica Y Lyall, John P Welsh, Sean Burgess, Vijesh Kumar, Steven M Cramer

Biotechnol Prog· December 2024

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In silico mediated workflow for rapid development of downstream processing: Orthogonal product-related impurity removal for a Fc-containing therapeutic.
Dongyoun Jang, Scott H Altern, Steven M Cramer

J Chromatogr A· October 2024

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A batch screening technique for the calculation of chromatographic separability.
Eric Denbaum, Scott H Altern, Nicholas Vecchiarello, Steven M Cramer

J Chromatogr A· September 2024

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Implications of AAV affinity column reuse and vector stability on product quality attributes.
Harshal Soni, Ira Lako, Matteo Placidi, Steven M Cramer

Biotechnol Bioeng· August 2024

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Continuous precipitation-filtration process for initial capture of a monoclonal antibody product using a four-stage countercurrent hollow fiber membrane washing step.
Mirko Minervini, Matthew Mergy, Yuncan Zhu, Mario A Gutierrez Diaz, Craig Pointer, Steven M Cramer

Biotechnol Bioeng· August 2024

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Exploring preferred binding domains of IgG1 mAbs to multimodal adsorbents using a combined biophysics and simulation approach.
Kabir Dhingra, Imee Sinha, Mark Snyder, David Roush, Steven M Cramer

Biotechnol Prog· April 2024

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Factors affecting product association as a mechanism of host-cell protein persistence in bioprocessing.
Young Hoon Oh, Matthew L Becker, Kerri M Mendola, Leila H Choe, Lie Min, Steven M Cramer

Biotechnol Bioeng· April 2024

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Mixed-mode size-exclusion silica resin for polishing human antibodies in flow-through mode.
Jacob P LeBarre, Wenning Chu, Scott H Altern, Andrew J Kocot, Dipendra Bhandari, Steven M Cramer

J Chromatogr A· April 2024

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Mechanistic model-based characterization of size-exclusion-mixed-mode resins for removal of monoclonal antibody fragments.
Scott H Altern, Andrew J Kocot, Jacob P LeBarre, Cristiana Boi, Michael W Phillips, Steven M Cramer

J Chromatogr A· March 2024

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Identification and characterization of CHO host-cell proteins in monoclonal antibody bioprocessing.
Young Hoon Oh, Kerri M Mendola, Leila H Choe, Lie Min, Ashton R Lavoie, Steven M Cramer

Biotechnol Bioeng· January 2024

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Comparative Analysis of Protein Surface Hydrophobicity Maps Determined by Sparse Sampling INDUS and Spatial Aggregation Propensity.
Imee Sinha, Shekhar Garde, Steven M Cramer

J Phys Chem B· December 2023

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Evaluation of preferred binding regions on ubiquitin and IgG1 F for interacting with multimodal cation exchange resins using DEPC labeling/mass spectrometry.
Kabir Dhingra, Ronak B Gudhka, Steven M Cramer

Biotechnol Bioeng· June 2023

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Characterization and implications of host-cell protein aggregates in biopharmaceutical processing.
Young Hoon Oh, Matthew L Becker, Kerri M Mendola, Leila H Choe, Lie Min, Steven M Cramer

Biotechnol Bioeng· April 2023

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Isotherm model discrimination for multimodal chromatography using mechanistic models derived from high-throughput batch isotherm data.
Scott H Altern, John P Welsh, Jessica Y Lyall, Andrew J Kocot, Sean Burgess, Steven M Cramer

J Chromatogr A· March 2023

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Evaluation of lentiviral vector stability and development of ion exchange purification processes.
Ronit Ghosh, Sushmita Koley, Sneha Gopal, Andre L Rodrigues, Jonathan S Dordick, Steven M Cramer

Biotechnol Prog· November 2022

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Connecting Non-Gaussian Water Density Fluctuations to the Lengthscale Dependent Crossover in Hydrophobic Hydration.
Imee Sinha, Steven M Cramer, Henry S Ashbaugh, Shekhar Garde

J Phys Chem B· October 2022

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Association of Frailty, Age, and Biological Sex With Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccine-Induced Immunity in Older Adults.
Janna R Shapiro, Ioannis Sitaras, Han Sol Park, Tihitina Y Aytenfisu, Christopher Caputo, Steven M Cramer

Clin Infect Dis· August 2022

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Towards continuous mAb purification: Clearance of host cell proteins from CHO cell culture harvests via "flow-through affinity chromatography" using peptide-based adsorbents.
Sobhana Alekhya Sripada, Wenning Chu, Taufika Islam Williams, Matthew A Teten, Brian J Mosley, Steven M Cramer

Biotechnol Bioeng· July 2022

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Development of QSAR models for screening of antibody solubility.
Xuan Han, James Shih, Yuhao Lin, Qing Chai, Steven M Cramer

MAbs· April 2022

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Adaptive immune responses in vaccinated patients with symptomatic SARS-CoV-2 Alpha infection.
Han-Sol Park, Janna R Shapiro, Ioannis Sitaras, Bezawit A Woldemeskel, Caroline C Garliss, Steven M Cramer

JCI Insight· March 2022

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Understanding the effects of system differences for parameter estimation and scale-up of high throughput chromatographic data.
William R Keller, Steven T Evans, Gisela Ferreira, David Robbins, Steven M Cramer

J Chromatogr A· January 2022

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