Publications by authors named "Stuart A Forman"

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Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site.
Anahita Nourmahnad, Alex T Stern, Mayo Hotta, Deirdre S Stewart, Alexis M Ziemba, Andrea Szabo, Stuart A Forman

Anesthesiology· December 2016

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Substituted cysteine modification and protection indicates selective interactions of the anesthetic photolabel pTFD-di-iPr-BnOH with α+/β- and α+/γ- transmembrane subunit interfaces of synaptic GABAA receptors.
Kieran Bhave, Stuart A Forman

PLoS One· November 2025

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Glabridin Hypnosis in Zebrafish Larvae Is Associated With Effects on Multiple Anesthetic Target Receptors.
Aneesh Avancha, Helen Hoyt, Kieran Bhave, Madyson Medeiros, Daniel Cho, Stuart A Forman

Anesth Analg· September 2025

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Systematized Serendipity: Fishing Expeditions for Anesthetic Drugs and Targets.
C Michael Crowder, Stuart A Forman

Anesthesiology· November 2024

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Substituted Cysteine Modification and Protection with n-Alkyl-MTS Reagents Quantifies Steric Changes Induced by a Mutation in Anesthetic Binding Sites on GABA Type A Receptors.
Kieran Bhave, Stuart A Forman

Mol Pharmacol· December 2023

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Competitive Interactions Between Propofol and Diazepam: Studies in GABA Receptors and Zebrafish.
Andrea Pence, Helen Hoyt, Megan McGrath, Stuart A Forman, Douglas E Raines

J Pharmacol Exp Ther· December 2022

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Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors.
Helen Hoyt, Ryan J Fantasia, Kieran Bhave, Xiaoxuan Yang, Stuart A Forman

Anesthesiology· November 2022

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Utilizing Pharmacogenomic Data in Perioperative Medicine: Feasibility, Value, and Inevitability.
Stuart A Forman, Ken B Johnson

Anesth Analg· November 2022

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γ-Aminobutyric Acid Type A Receptor Subtypes and Circuit Connections in Midazolam-induced Amnesia, Sedation, and Hypnosis.
Stuart A Forman

Anesthesiology· June 2022

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Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA receptor: In vitro and in vivo studies.
Megan McGrath, Helen Hoyt, Andrea Pence, Stuart A Forman, Douglas E Raines

Br J Pharmacol· December 2021

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Substituted Cysteine Modification and Protection with -Alkyl- Methanethiosulfonate Reagents Yields a Precise Estimate of the Distance between Etomidate and a Residue in Activated GABA Type A Receptors.
Ryan J Fantasia, Anahita Nourmahnad, Elizabeth Halpin, Stuart A Forman

Mol Pharmacol· June 2021

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New Evidence of Receptor-based Pharmacology Underlying a Volatile Anesthetic Effect.
Stuart A Forman

Anesthesiology· November 2020

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Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies.
Megan McGrath, Helen Hoyt, Andrea Pence, Selwyn S Jayakar, Xiaojuan Zhou, Stuart A Forman

Anesthesiology· September 2020

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A potent photoreactive general anesthetic with novel binding site selectivity for GABA receptors.
Abdelrahman R Shalabi, Zhiyi Yu, Xiaojuan Zhou, Youssef Jounaidi, Hanwen Chen, Stuart A Forman

Eur J Med Chem· May 2020

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Effects of Anticholinesterase Reversal Under General Anesthesia on Postoperative Cardiovascular Complications: A Retrospective Cohort Study.
Denys Shay, Flora T Scheffenbichler, Barry J Kelly, Anne-Louise Lihn, Hao Deng, Stuart A Forman

Anesth Analg· March 2020

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Drug-selective Anesthetic Insensitivity of Zebrafish Lacking γ-Aminobutyric Acid Type A Receptor β3 Subunits.
Xiaoxuan Yang, Youssef Jounaidi, Kusumika Mukherjee, Ryan J Fantasia, Eric C Liao, Stuart A Forman

Anesthesiology· December 2019

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Combining Mutations and Electrophysiology to Map Anesthetic Sites on Ligand-Gated Ion Channels.
Stuart A Forman

Methods Enzymol· April 2019

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Monod-Wyman-Changeux Allosteric Shift Analysis in Mutant 132L GABA Receptors Indicates Selectivity and Crosstalk among Intersubunit Transmembrane Anesthetic Sites.
Andrea Szabo, Anahita Nourmahnad, Elizabeth Halpin, Stuart A Forman

Mol Pharmacol· April 2019

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Etomidate Effects on Desensitization and Deactivation of 43 GABA Receptors Inducibly Expressed in HEK293 TetR Cells.
Yiwei Liao, Xiang Liu, Youssef Jounaidi, Stuart A Forman, Hua-Jun Feng

J Pharmacol Exp Ther· January 2019

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Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors.
Bo Wu, Selwyn S Jayakar, Xiaojuan Zhou, Katherine Titterton, David C Chiara, Stuart A Forman

Eur J Med Chem· January 2019

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High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics.
Xiaoxuan Yang, Youssef Jounaidi, Jennifer B Dai, Francisco Marte-Oquendo, Elizabeth S Halpin, Stuart A Forman

Anesthesiology· September 2018

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Comparison of αβδ and αβγ GABA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics.
Hua-Jun Feng, Stuart A Forman

Pharmacol Res· July 2018

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Propofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABA Receptors.
Daniel J Shin, Allison L Germann, Alexander D Johnson, Stuart A Forman, Joe Henry Steinbach

Mol Pharmacol· February 2018

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Alphaxalone Binds in Inner Transmembrane β+-α- Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors.
Alexis M Ziemba, Andrea Szabo, David W Pierce, Marian Haburcak, Alex T Stern, Stuart A Forman

Anesthesiology· February 2018

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Tethering IL2 to Its Receptor IL2Rβ Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells.
Youssef Jounaidi, Joseph F Cotten, Keith W Miller, Stuart A Forman

Cancer Res· November 2017

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Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.
Pavel Y Savechenkov, David C Chiara, Rooma Desai, Alexander T Stern, Xiaojuan Zhou, Stuart A Forman

Eur J Med Chem· August 2017

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