Publications by authors named "T Schaedler"

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Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor.
Sam E Mann, Julien Lefranc, Omar Alkhatib, Roch Boivin, Jörg Bomke, Theresia A Schaedler

J Med Chem· October 2025

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Correction to "Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta".
Martin L Stockley, Giovanni Benedetti, Peter Blencowe, Simon J Boulton, Susan M Boyd, Theresia Schaedler

J Med Chem· February 2023

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Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Martin L Stockley, Amanda Ferdinand, Giovanni Benedetti, Peter Blencowe, Susan M Boyd, Theresia Schaedler

J Med Chem· October 2022

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Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
Diana Zatreanu, Helen M R Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Theresia Schaedler

Nat Commun· June 2021

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Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose.
David J Carrier, Carlo W T van Roermund, Theresia A Schaedler, Hong Lin Rong, Lodewijk IJlst

Sci Rep· July 2019

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