Publications by authors named "Takashi Higuchi"

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Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression.
Takashi Higuchi, Akihiko Takeuchi, Seiichi Munesue, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Inatani, Shingo Shimozaki, Takashi Kato

Cancer Med· May 2018

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Cis-unsaturated sphingolipids support growth of sphingoid base-deficient yeast but impair plasma membrane integrity.
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi

FEBS Open Bio· December 2025

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FDG- and MET-PET Imaging Reveal Glucose and Methionine Addiction in a Primary Endometrial Cancer and Methionine Addiction only in a Para-aortic Lymph-node Metastasis in a 58-year-old Patient.
Yohei Asano, Toshihiko Sato, Chihiro Hozumi, Qinghong Han, Shukuan Li, Takashi Higuchi

Anticancer Res· December 2025

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Rapid Eradication of Extensive Spinal Metastases in a Prostate-Cancer Patient Taking Androgen-deprivation Therapy, Chemotherapy, and Oral Recombinant Methioninase on a Low-Methionine Diet.
Yohei Asano, Qinghong Han, Shukuan Li, Toshihiko Sato, Chihiro Hozumi, Takashi Higuchi

Anticancer Res· December 2025

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Selective Synergy of the Combination of Recombinant Methioninase With Cisplatinum and Ivermectin Which Eradicates Lung-Cancer Cells but Has No Synergy and Limited Effect on Normal Fibroblasts.
Yohei Asano, Qinghong Han, Shukuan Li, Kohei Mizuta, Byung Mo Kang, Takashi Higuchi

Anticancer Res· December 2025

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Isotope-selective Ion trapping via sympathetic cooling using a surface-electrode trap with a hole for collimated atomic loading.
Masanari Miyamoto, Takashi Higuchi, Kentaro Furusawa, Norihiko Sekine, Kazuhiro Hayasaka

Sci Rep· December 2025

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Lengthened telomere length in peripheral blood leukocytes in patients with rheumatoid arthritis complicated with airway disease.
Takashi Higuchi, Shomi Oka, Kota Shimada, Shinichiro Tsunoda, Satoshi Ito

BMC Rheumatol· December 2025

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An unusual presentation of a large lower extremity abscess caused by Aggregatibacter aphrophilus: A case report.
Takashi Higuchi, Yoshihiro Araki, Mikino Saito, Atsushi Taninaka, Satoru Demura

Int J Surg Case Rep· November 2025

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Very Rapid Eradication of a Large Squamous-Cell Carcinoma of the Head and Neck Treated With First-line Combination Chemotherapy, a Low-methionine Diet, and Oral Recombinant Methioninase.
Yohei Asano, Qinghong Han, Shukuan Li, Kohei Mizuta, Byung Mo Kang, Takashi Higuchi

Anticancer Res· November 2025

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Triple Combination of Recombinant Methioninase and the Anti-parasitic Drugs Ivermectin, and Chloroquine Selectively Eradicates Pancreatic Cancer Cells While Sparing Normal Fibroblasts.
Yohei Asano, Qinghong Han, Shukuan Li, Kohei Mizuta, Byung Mo Kang, Takashi Higuchi

Anticancer Res· November 2025

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Factors Associated with Bone Union Failure After Frozen Autograft Reconstruction in Lower Limb Osteosarcoma.
Sei Morinaga, Katsuhiro Hayashi, Shinji Miwa, Takashi Higuchi, Hirotaka Yonezawa

Cancers (Basel)· November 2025

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Anti- lipopolysaccharide antibody in rheumatoid arthritis patients with emphysema.
Shomi Oka, Takashi Higuchi, Kota Shimada, Misuzu Fujimori, Atsushi Hashimoto

Front Med (Lausanne)· October 2025

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Urine phospholipid profiling in patients with rheumatoid arthritis and nontuberculous mycobacterial pulmonary disease.
Hiroshi Furukawa, Shomi Oka, Takashi Higuchi, Akira Okamoto, Misuzu Fujimori

Sci Rep· October 2025

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A perspective on patient-derived orthotopic xenograft (PDOX) mouse models for identification of novel and individualized treatment for sarcoma.
Takashi Higuchi, Kentaro Igarashi, Shinji Miwa, Hiroaki Kimura, Katsuhiro Hayashi

Int J Clin Oncol· September 2025

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Eradication of Extensive Lymph-Node, Bone and Pleural Metastases of a Breast-Cancer Patient Treated With Radiation, Immunotherapy and Oral Recombinant Methioninase.
Yohei Asano, Toshihiko Sato, Qinghong Han, Shukuan Li, Chihiro Hozumi, Takashi Higuchi

Cancer Diagn Progn· September 2025

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Limited predictive value of pretreatment P-glycoprotein immunostaining for chemotherapy efficacy and survival in long-follow-up osteosarcoma patients.
Takashi Higuchi, Kentaro Igarashi, Shinji Miwa, Akihiko Takeuchi, Katsuhiro Hayashi

Medicine (Baltimore)· August 2025

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The Combination of the Autophagy Inhibitor Chloroquine and Recombinant Methioninase Has Selective Synergistic Efficacy on Human Colon Cancer Cells But Not on Normal Human Fibroblasts.
Yohei Asano, Qinghong Han, Shukuan Li, Kohei Mizuta, Byung Mo Kang, Takashi Higuchi

Anticancer Res· July 2025

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Adeno-associated virus expressing a blood-brain barrier-penetrating enzyme improves GM1 gangliosidosis in a preclinical model.
Saki Kondo Matsushima, Yohta Shimada, Masafumi Kinoshita, Takashi Nagashima, Shinichiro Okamoto, Takashi Higuchi

J Clin Invest· June 2025

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Selective Synergy of Ivermectin Combined With Recombinant Methioninase Against Colon-Cancer Cells in Contrast to Normal Fibroblasts.
Yohei Asano, Qinghong Han, Shukuan Li, Kohei Mizuta, Byung Mo Kang, Takashi Higuchi

Anticancer Res· June 2025

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Voluntary Exercise-Induced Skeletal Muscle Responses in Young and Aged Mice on a High-Fat Diet.
Yuji Kanazawa, Kenichiro Miyahara, Tatsuo Takahashi, Ryo Miyachi, Takashi Higuchi

Cureus· June 2025

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HT1080 Fibrosarcoma With Acquired Trabectedin Resistance: Increased Malignancy But Sustained Sensitivity to Methionine Restriction.
Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung Mo Kang, Michael Bouvet, Takashi Higuchi

In Vivo· May 2025

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Recombinant Methioninase and Cisplatinum Act Synergistically to Inhibit Lewis Lung Carcinoma Cells But Not Normal Fibroblasts.
Yohei Asano, Qinghong Han, Kohei Mizuta, Byung Mo Kang, Jin Soo Kim, Takashi Higuchi

Anticancer Res· May 2025

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Perspective on an Innovative Curative Strategy for Peritoneal Metastasis Involving Peritonectomy, Hyperthermic Intraperitoneal Chemotherapy, and Adjuvant Chemotherapy Identified as Effective in the Histoculture Drug Response Assay (HDRA).
Yohei Asano, Yutaka Yonemura, Chihiro Hozumi, Kohei Mizuta, Byung Mo Kang, Takashi Higuchi

Cancer Diagn Progn· May 2025

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Primary Osseous Leiomyosarcoma of Talus Mimicking Idiopathic Transient Osteoporosis: A Case Report and Literature Review.
Takashi Katsuo, Takashi Higuchi, Shinji Miwa, Katsuhiro Hayashi, Satoru Demura

Cureus· May 2025

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HT1080 Human Fibrosarcoma Cells Selected for Super-eribulin Resistance Become More Malignant and Are Arrested Synergistically by Methionine Restriction in Combination With Eribulin in Nude Mice.
Sei Morinaga, Kohei Mizuta, Byung Mo Kang, Qinghong Han, Michael Bouvet, Takashi Higuchi

In Vivo· April 2025

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Highly Synergistic Eradication of 143B Osteosarcoma Cells by the Combination of Recombinant Methioninase, Chloroquine, and Rapamycin Targeting Methionine Addiction, Autophagy, and mTOR, Respectively.
Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung Mo Kang, Michael Bouvet, Takashi Higuchi

Anticancer Res· March 2025

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