Publications by authors named "Taraneh Hajian"

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Systematic Design of Adenosine Analogs as Inhibitors of a Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Jujun Zhou, John R Horton, Martina Menna, Francesco Fiorentino, Ren Ren, Dan Yu, Taraneh Hajian, Masoud Vedadi, Giulia Mazzoccanti, Alessia Ciogli

J Med Chem· January 2023

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Inhibition of -Specific DNA Adenine Methyltransferase CamA by Analogs of ‑Adenosyl‑l‑methionine.
Jujun Zhou, Youchao Deng, Dan Yu, Taraneh Hajian, Masoud Vedadi

ACS Omega· December 2025

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OICR-41103 as a chemical probe for the DCAF1 WD40 domain.
Serah W Kimani, Mahmoud Noureldin, Brian Wilson, Laurent Hoffer, Stuart R Green, Taraneh Hajian

Commun Biol· July 2025

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Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.
Mark F Mabanglo, Brian Wilson, Mahmoud Noureldin, Serah W Kimani, Ahmed Mamai, Taraneh Hajian

Nat Commun· November 2024

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Kinetic characterization of human mRNA guanine-N7 methyltransferase.
Sumera Perveen, Aliakbar Khalili Yazdi, Taraneh Hajian, Fengling Li, Masoud Vedadi

Sci Rep· February 2024

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SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses.
Fengling Li, Pegah Ghiabi, Taraneh Hajian, Martin Klima, Alice Shi Ming Li

Biochim Biophys Acta Gen Subj· April 2023

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Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2.
Ronan P Hanley, David Y Nie, John R Tabor, Fengling Li, Amin Sobh, Taraneh Hajian

J Am Chem Soc· April 2023

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Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Specific DNA Adenine Methyltransferase.
Jujun Zhou, Youchao Deng, Iredia D Iyamu, John R Horton, Dan Yu, Taraneh Hajian

ACS Chem Biol· April 2023

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Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16.
Martin Klima, Aliakbar Khalili Yazdi, Fengling Li, Irene Chau, Taraneh Hajian

Protein Sci· September 2022

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Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors.
Aliakbar Khalili Yazdi, Paknoosh Pakarian, Sumera Perveen, Taraneh Hajian, Vijayaratnam Santhakumar

ACS Infect Dis· August 2022

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Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.
Dan Yu, John R Horton, Jie Yang, Taraneh Hajian, Masoud Vedadi

Nucleic Acids Res· November 2021

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Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors.
Kanchan Devkota, Matthieu Schapira, Sumera Perveen, Aliakbar Khalili Yazdi, Fengling Li, Taraneh Hajian

SLAS Discov· October 2021

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A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex.
Aliakbar Khalili Yazdi, Fengling Li, Kanchan Devkota, Sumera Perveen, Pegah Ghiabi, Taraneh Hajian

SLAS Discov· July 2021

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A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19.
Sumera Perveen, Aliakbar Khalili Yazdi, Kanchan Devkota, Fengling Li, Pegah Ghiabi, Taraneh Hajian

SLAS Discov· June 2021

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Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors.
Kanchan Devkota, Matthieu Schapira, Sumera Perveen, Aliakbar Khalili Yazdi, Fengling Li, Taraneh Hajian

bioRxiv· February 2021

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Correction: A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.
Xiao-Chuan Cai, Tuo Zhang, Eui-Jun Kim, Ming Jiang, Ke Wang, Taraneh Hajian

Elife· October 2020

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Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro.
Clayton B Woodcock, Dan Yu, Taraneh Hajian, Jia Li, Yun Huang

Cell Discov· December 2019

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A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.
Xiao-Chuan Cai, Tuo Zhang, Eui-Jun Kim, Ming Jiang, Ke Wang, Taraneh Hajian

Elife· October 2019

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Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain.
Guillermo Senisterra, Hugh Y Zhu, Xiao Luo, Hailong Zhang, Guoliang Xun, Taraneh Hajian

SLAS Discov· October 2018

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Targeting human SET1/MLL family of proteins.
Masoud Vedadi, Levi Blazer, Mohammad S Eram, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Taraneh Hajian

Protein Sci· April 2017

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A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5.
Fengling Li, Steven Kennedy, Taraneh Hajian, Elisa Gibson, Alma Seitova

J Biomol Screen· March 2016

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Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).
Matthäus Getlik, David Smil, Carlos Zepeda-Velázquez, Yuri Bolshan, Gennady Poda, Taraneh Hajian

J Med Chem· March 2016

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Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1.
Yepeng Luan, Levi L Blazer, Hao Hu, Taraneh Hajian, Jing Zhang

Org Biomol Chem· January 2016

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A scintillation proximity assay for histone demethylases.
Wenyu Yu, Mohammad S Eram, Taraneh Hajian, Aleksandra Szykowska, Nicola Burgess-Brown

Anal Biochem· October 2014

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Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein.
Mohammad S Eram, Susan P Bustos, Evelyne Lima-Fernandes, Alena Siarheyeva, Guillermo Senisterra, Taraneh Hajian

J Biol Chem· April 2014

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