Publications by authors named "Targan Stephan"

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Relationship of Intestinal Ultrasound With Clinical, Biochemical, and Endoscopic Disease Severity in Acute Severe Ulcerative Colitis: A Blinded, Prospective Study.
Phillip Gu, David Ziring, Puja V Khanna, Waseem Ahmed, Eric Vasiliauskas, Stephan Targan

Clin Transl Gastroenterol· September 2025

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Safety and efficacy of the anti-TL1A monoclonal antibody tulisokibart for Crohn's disease: a phase 2a induction trial.
Brian G Feagan, Bruce E Sands, Corey A Siegel, Marla C Dubinsky, Randy S Longman, Stephan R Targan

Lancet Gastroenterol Hepatol· August 2025

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TL1A: A model for a precision medicine approach in the treatment of Crohn's disease and ulcerative colitis.
Janine M Bilsborough, Stephan R Targan

Adv Pharmacol· November 2024

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Toll-like receptor 7 protects against intestinal inflammation and restricts the development of colonic tissue-resident memory CD8 T cells.
Hussein Hamade, Masato Tsuda, Naoki Oshima, Dalton T Stamps, Michelle H Wong, Stephan R Targan

Front Immunol· October 2024

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Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis.
Bruce E Sands, Brian G Feagan, Laurent Peyrin-Biroulet, Silvio Danese, David T Rubin, Stephan Targan

N Engl J Med· September 2024

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Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease.
Michelle Khrom, Millie Long, Shishir Dube, Lori Robbins, Gregory J Botwin, Stephan R Targan

Gastroenterology· July 2024

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Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn's disease.
Phillip Gu, Shishir Dube, Norman Gellada, So Yung Choi, Susan Win, Stephan R Targan

World J Gastrointest Surg· March 2024

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Evolution of Symptoms After Ustekinumab Induction Therapy in Patients With Crohn's Disease.
Jean-Frédéric Colombel, Bruce E Sands, Christopher Gasink, Benjamin Yeager, Omoniyi J Adedokun, Stephan R Targan

Clin Gastroenterol Hepatol· January 2024

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Comparative Persistence of Non-tumor Necrosis Factor (TNF) vs. TNF Antagonists for Post-operative Prophylaxis in Crohn's Disease (CD).
Phillip Gu, Shishir Dube, YooJin Lee, Shaohong Yang, Dalin Li, Stephan Targan

Dig Dis Sci· January 2024

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Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.
Marzieh Akhlaghpour, Talin Haritunians, Shyam K More, Lisa S Thomas, Dalton T Stamps, Stephan R Targan

Gut· November 2023

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Combination Therapy With Immunomodulators Improves the Pharmacokinetics of Infliximab But Not Vedolizumab or Ustekinumab.
Andres J Yarur, Dermot McGovern, Maria T Abreu, Adam Cheifetz, Konstantinos Papamichail, Stephan R Targan

Clin Gastroenterol Hepatol· October 2023

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Higher Intra-Abdominal Visceral Adipose Tissue Mass Is Associated With Lower Rates of Clinical and Endoscopic Remission in Patients With Inflammatory Bowel Diseases Initiating Biologic Therapy: Results of the Constellation Study.
Andres J Yarur, Alexandra Bruss, Andrea Moosreiner, Poonam Beniwal-Patel, Lizbeth Nunez, Stephan R Targan

Gastroenterology· October 2023

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DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier Injury.
Yosuke Shimodaira, Shyam K More, Hussein Hamade, Anna Y Blackwood, Jay P Abraham, Stephan R Targan

Cell Mol Gastroenterol Hepatol· June 2023

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Diagnostic and therapeutic potential of RNASET2 in Crohn's disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion.
Eva Biener-Ramanujan, Florian Rosier, Simon G Coetzee, Dermot D P McGovern, Dennis Hazelett, Stephan R Targan

Front Immunol· December 2022

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Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.
Aleksejs Sazonovs, Christine R Stevens, Guhan R Venkataraman, Kai Yuan, Brandon Avila, Stephan Targan

Nat Genet· September 2022

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Crohn's disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome.
Jonathan P Jacobs, Maryam Goudarzi, Venu Lagishetty, Dalin Li, Tytus Mak, Stephan Targan

Genome Med· August 2022

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BATF3 Protects Against Metabolic Syndrome and Maintains Intestinal Epithelial Homeostasis.
Hussein Hamade, Jasmine T Stamps, Dalton T Stamps, Shyam K More, Lisa S Thomas, Stephan R Targan

Front Immunol· July 2022

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Development of a Personalized Intestinal Fibrosis Model Using Human Intestinal Organoids Derived From Induced Pluripotent Stem Cells.
Hannah Q Estrada, Shachi Patel, Shervin Rabizadeh, David Casero, Stephan R Targan

Inflamm Bowel Dis· May 2022

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Five-Year Efficacy and Safety of Ustekinumab Treatment in Crohn's Disease: The IM-UNITI Trial.
William J Sandborn, Rory Rebuck, Yuhua Wang, Bin Zou, Omoniyi J Adedokun, Stephan Targan

Clin Gastroenterol Hepatol· March 2022

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TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization.
Yuxin Luo, Jinbo Guo, Wenxiu Jia, Mengyao Wu, Fengrong Yin, Stephan R Targan

Oxid Med Cell Longev· March 2022

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Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis.
Jia Wenxiu, Yang Mingyue, Han Fei, Luo Yuxin, Wu Mengyao, Stephan R Targan

Mediators Inflamm· January 2022

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Decreased Antibody Responses to Ad26.COV2.S Relative to SARS-CoV-2 mRNA Vaccines in Patients With Inflammatory Bowel Disease.
Valeriya Pozdnyakova, Gregory J Botwin, Kimia Sobhani, John Prostko, Jonathan Braun, Stephan Targan

Gastroenterology· December 2021

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Preoperative Serum Vedolizumab Levels Do Not Impact Postoperative Outcomes in Inflammatory Bowel Disease.
Aaron B Parrish, Nicole E Lopez, Adam Truong, Karen Zaghiyan, Gil Y Melmed, Stephan R Targan

Dis Colon Rectum· October 2021

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Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn's Disease.
Corey A Siegel, Lori S Siegel, Marla C Dubinsky, Stephan Targan, Jonathan Braun

Crohns Colitis 360· October 2021

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Antitumour necrosis factor therapy is associated with de novo Crohn's disease after ileal pouch-anal anastomosis.
Adam Truong, Karen N Zaghiyan, James Mirocha, Gil Y Melmed, Dermot P B McGovern, Stephan R Targan

Colorectal Dis· September 2021

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