Publications by authors named "Thomas Durcan"

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Activation of endogenous PRKN by structural derepression is linked to increased turnover of the E3 ubiquitin ligase.
Fabienne C Fiesel, Bernardo A Bustillos, Jens O Watzlawik, Carol X Q Chen, Martin H Berryer, Thomas M Durcan

Autophagy· December 2025

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Developing a National Network for Leukodystrophy Research and Care in Canada: The CARELeuko Initiative.
Alexandra Chapleau, Adam Le, Justin Simo, Sunita Venkateswaran, Thierry Lacaze-Masmonteil, Thomas M Durcan

Neurol Genet· December 2025

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A guide to selecting high-performing antibodies for Heterogeneous nuclear ribonucleoproteins A2/B1(hnRNP A2/B1) (UniProt ID: P22626) for use in western blot, immunoprecipitation, and immunofluorescence.
Vera Ruíz Moleón, Riham Ayoubi, Charles Alende, Maryam Fothouhi, Joel Ryan, Thomas M Durcan

F1000Res· December 2025

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α-Synuclein purification significantly impacts seed amplification assay performance and consistency.
Zaid A M Al-Azzawi, Nicholas R G Silver, Surabhi Mehra, Simeng Niu, Christopher Situ, Thomas M Durcan

Acta Neuropathol Commun· November 2025

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A scoping review of stem cell models of leukodystrophies: advances in understanding pathophysiological mechanisms.
Alexandra Chapleau, Stefanie Perrier, Thomas M Durcan, Geneviève Bernard

NPJ Genom Med· November 2025

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Adrenergic Control of P2Y6 Receptor-Dependent Phagocytosis in Rodent and Human Microglia.
Thomas Deluc, Ariel Ase, Marie-France Dorion, Gilles Maussion, Yeman Tang, Thomas M Durcan

Glia· October 2025

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Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils.
Benoît Vanderperre, Amitha Muraleedharan, Marie-France Dorion, Frédérique Larroquette, Esther Del Cid Pellitero, Thomas M Durcan

Commun Biol· October 2025

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Neuraminidase 1 secondary deficiency contributes to CNS pathology in neurological mucopolysaccharidoses via brain protein hypersialylation.
TianMeng Xu, Rachel Heon-Roberts, Travis Moore, Patricia Dubot, Xuefang Pan, Thomas M Durcan

J Clin Invest· August 2025

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Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924.
Sarah Lépine, Gilles Maussion, Alexandria Schneider, Angela Nauleau-Javaudin, María José Castellanos-Montiel, Thomas M Durcan

Sci Rep· August 2025

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14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation.
Sabri A Rial, Zhipeng You, Alexis Vivoli, Fédéric Paré, Daphné Sean, Thomas M Durcan

Mol Metab· July 2025

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Pro-Inflammatory Molecules Implicated in Multiple Sclerosis Divert the Development of Human Oligodendrocyte Lineage Cells.
Gabriela J Blaszczyk, Abdulshakour Mohammadnia, Valerio E C Piscopo, Julien Sirois, Qiao-Ling Cui, Thomas M Durcan

Neurol Neuroimmunol Neuroinflamm· July 2025

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Derivation and Culture of Enriched Phrenic-Like Motor Neurons From Human iPSCs.
Louise Thiry, Julien Sirois, Thomas M Durcan, Stefano Stifani

Bio Protoc· July 2025

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Multiplex Immunofluorescent Batch Labeling of Marmoset Brain Sections.
Daryan Chitsaz, Christopher D Rowley, Nonthué A Uccelli, Sarah Lefebvre, Andrea I Krahn, Thomas M Durcan

Brain Behav· April 2025

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Single cell RNAseq to identify subpopulations of glial progenitors in iPSC-derived oligodendroglial lineage cultures.
Gabriela J Blaszczyk, Valerio E C Piscopo, Taylor M Goldsmith, Alexandra Chapleau, Julien Sirois, Thomas M Durcan

NPJ Syst Biol Appl· April 2025

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Evaluation of Additive Neuroprotective Effect of Combination Therapy for Parkinson's Disease Using In Vitro Models.
Alexander Shtilbans, Elise Esneault, Florian Simon, Joseph R Mazzulli, Drew J Quiriconi, Thomas M Durcan

Antioxidants (Basel)· March 2025

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Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils.
Stephanie Tullo, Janice Sung Hyun Park, Daniel Gallino, Megan Park, Kristie Mar, Thomas M Durcan

Commun Biol· February 2025

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Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.
Alex G Baldwin, David W Foley, Ross Collins, Hyunah Lee, D Heulyn Jones, Thomas M Durcan

J Med Chem· January 2025

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Modeling Parkinson's disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines.
Armin Bayati, Riham Ayoubi, Adriana Aguila, Cornelia E Zorca, Ghislaine Deyab, Thomas M Durcan

Nat Neurosci· December 2024

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Correction: The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.
Jace Jones-Tabah, Kathy He, Nathan Karpilovsky, Konstantin Senkevich, Ghislaine Deyab, Thomas M Durcan

Mol Neurodegener· December 2024

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Combination of tauroursodeoxycholic acid, co-enzyme Q10 and creatine demonstrates additive neuroprotective effects in models of Parkinson's disease.
Alexander Shtilbans, Wolfgang E Reintsch, Valerio E C Piscopo, Andrea I Krahn, Thomas M Durcan

Front Neurosci· December 2024

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The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.
Jace Jones-Tabah, Kathy He, Nathan Karpilovsky, Konstantin Senkevich, Ghislaine Deyab, Thomas M Durcan

Mol Neurodegener· November 2024

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CelltypeR: A flow cytometry pipeline to characterize single cells from brain organoids.
Rhalena A Thomas, Julien Sirois, Shuming Li, Alexandre Gestin, Ghislaine Deyab, Thomas M Durcan

iScience· September 2024

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Microfabricated dynamic brain organoid cocultures to assess the effects of surface geometry on assembloid formation.
Camille Cassel de Camps, Sabra Rostami, Vanessa Xu, Chen Li, Paula Lépine, Thomas M Durcan

Biotechnol J· August 2024

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Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy.
Emily Banks, Vincent Francis, Sheng-Jia Lin, Fares Kharfallah, Vladimir Fonov, Thomas M Durcan

Nat Commun· August 2024

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An Inducible Luminescent System to Explore Parkinson's Disease-Associated Genes.
Anelya Gandy, Gilles Maussion, Sara Al-Habyan, Michael Nicouleau, Zhipeng You, Thomas M Durcan

Int J Mol Sci· August 2024

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