Publications by authors named "Thomas Leto"

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Genotype-specific immune responses at the intestinal barrier predispose to colitis in mouse models of chronic granulomatous disease.
Emma Darbinian, Kodjovi D Mlaga, Prabha Chandrasekaran, Yu Han, Ágnes Donkó, Thomas L Leto

Blood· June 2025

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Challenging the role of a NOX4-Piezo1 axis in neutrophil bactericidal function.
Ulla G Knaus, Robert A Clark, William M Nauseef, Mary C Dinauer, Thomas L Leto

Immunity· August 2024

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BTK drives neutrophil activation for sterilizing antifungal immunity.
Jigar V Desai, Marissa A Zarakas, Andrew L Wishart, Mark Roschewski, Mariano A Aufiero, Thomas L Leto

J Clin Invest· May 2024

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Clinical and functional spectrum of RAC2-related immunodeficiency.
Ágnes Donkó, Svetlana O Sharapova, Juraj Kabat, Sundar Ganesan, Fabian H Hauck, Thomas L Leto

Blood· April 2024

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Case Report: Profound newborn leukopenia related to a novel RAC2 variant.
Geoffrey Hall, Ágnes Donkó, Cristina Pratt, Julie J Kim-Chang, Paul L Martin, Thomas L Leto

Front Pediatr· March 2024

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NOX1 and PRDX6 synergistically support migration and invasiveness of hepatocellular carcinoma cells through enhanced NADPH oxidase activity.
Daniel J Lagal, J Antonio Bárcena, Raquel Requejo-Aguilar, C Alicia Padilla, Thomas L Leto

Adv Redox Res· December 2023

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Loss of PRDX6 Aborts Proliferative and Migratory Signaling in Hepatocarcinoma Cell Lines.
Daniel J Lagal, María J López-Grueso, José R Pedrajas, Thomas L Leto, J Antonio Bárcena

Antioxidants (Basel)· May 2023

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Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury.
Hannah Mason, Ganesha Rai, Arina Kozyr, Nathaniel De Jonge, Emily Gliniewicz, Thomas L Leto

Redox Biol· April 2023

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Mutant p53 and NOX4 are modulators of a CCL5-driven pro-migratory secretome.
Howard E Boudreau, Agnieszka Korzeniowska, Thomas L Leto

Free Radic Biol Med· April 2023

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Immunogenetics associated with severe coccidioidomycosis.
Amy P Hsu, Agnieszka Korzeniowska, Cynthia C Aguilar, Jingwen Gu, Eric Karlins, Thomas L Leto

JCI Insight· November 2022

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Interpretation of Dihydrorhodamine-1,2,3 Flow Cytometry in Chronic Granulomatous Disease: an Atypical Exemplar.
Agnes Donko, Douglas B Kuhns, Margot A Cousin, Matthew J Smith, Keith A Sacco, Thomas L Leto

J Clin Immunol· July 2022

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Homozygous variant p. Arg90His in NCF1 is associated with early-onset Interferonopathy: a case report.
Oskar Schnappauf, Liane Heale, Dilan Dissanayake, Wanxia L Tsai, Massimo Gadina, Thomas L Leto

Pediatr Rheumatol Online J· April 2021

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A Novel RAC2 Variant Presenting as Severe Combined Immunodeficiency.
Heather Stern, Agnes Donkó, Teresa Shapiro, Amy P Hsu, Thomas L Leto

J Clin Immunol· February 2021

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Pan-Cancer Analysis Shows Mutations Modulate the Association of NOX4 with Genetic Programs of Cancer Progression and Clinical Outcome.
Wei Feng Ma, Howard E Boudreau, Thomas L Leto

Antioxidants (Basel)· February 2021

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Functional Characterization of DUOX Enzymes in Reconstituted Cell Models.
Agnieszka Korzeniowska, Ágnes P Donkó, Stanislas Morand, Thomas L Leto

Methods Mol Biol· January 2020

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Model Systems to Investigate NOX-Dependent Cell Migration and Invasiveness.
Howard E Boudreau, Thomas L Leto

Methods Mol Biol· January 2020

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PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner.
Terry W Moody, Lingaku Lee, Tatiana Iordanskaia, Irene Ramos-Alvarez, Paola Moreno, Thomas L Leto

Peptides· October 2019

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Heterozygous activating mutation in RAC2 causes infantile-onset combined immunodeficiency with susceptibility to viral infections.
Svetlana O Sharapova, Emma Haapaniemi, Inga S Sakovich, Larysa V Kostyuchenko, Agnes Donkó, Thomas L Leto

Clin Immunol· August 2019

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Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects.
Amy P Hsu, Agnes Donkó, Megan E Arrington, Muthulekha Swamydas, Danielle Fink, Thomas L Leto

Blood· May 2019

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Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide.
Ryuichi Sugamata, Agnes Donko, Yousuke Murakami, Howard E Boudreau, Chen-Feng Qi, Thomas L Leto

J Immunol· January 2019

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Interaction between p22 and Nox4 in the endoplasmic reticulum suggests a unique mechanism of NADPH oxidase complex formation.
Melinda Zana, Zalán Péterfi, Hajnal A Kovács, Zsuzsanna E Tóth, Balázs Enyedi, Thomas L Leto

Free Radic Biol Med· February 2018

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Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53.
Howard E Boudreau, Wei Feng Ma, Agnieszka Korzeniowska, Jonathan J Park, Medha A Bhagwat, Thomas L Leto

Oncotarget· July 2017

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Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium.
Fong-Fong Chu, R Steven Esworthy, James H Doroshow, Helmut Grasberger, Agnes Donko, Thomas L Leto

Redox Biol· April 2017

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Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration.
Jaeyul Kwon, Aibing Wang, Devin J Burke, Howard E Boudreau, Kristen J Lekstrom, Thomas L Leto

Free Radic Biol Med· July 2016

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When an Intramolecular Disulfide Bridge Governs the Interaction of DUOX2 with Its Partner DUOXA2.
Aurore Carré, Ruy A N Louzada, Rodrigo S Fortunato, Rabii Ameziane-El-Hassani, Stanislas Morand, Thomas L Leto

Antioxid Redox Signal· September 2015

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