Publications by authors named "Thomas Seeholzer"

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Translational Studies Using the MALT1 Inhibitor ()-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer.
Mauro Di Pilato, Yun Gao, Yi Sun, Amina Fu, Carina Grass, Thomas Seeholzer, Regina Feederle, Irina Mazo, Samuel W Kazer, Kevin Litchfield

J Immunother Precis Oncol· May 2023

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LUBAC modulates CBM complex functions downstream of TRAF6 in T cells.
Carina Graß, Franziska Ober, Constanze Sixt, Bahareh Nemati Moud, Irina Antoshkina, Thomas Seeholzer

Nat Commun· November 2025

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Resistome and Phylogenomics of Strains Obtained from Diverse Sources in Jimma, Ethiopia.
Mulatu Gashaw, Esayas Kebede Gudina, Guenter Froeschl, Ralph Matar, Solomon Ali, Thomas Seeholzer

Antibiotics (Basel)· July 2025

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Antibiotic Use Patterns at Jimma Medical Center in Southwest Ethiopia: A Call for Local Antibiogram-Guided Prescription.
Mulatu Gashaw, Melkamu Berhane, Sisay Bekele, Tsegaye Melaku, Gemechu Lemmi, Thomas Seeholzer

J Clin Med· April 2025

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Neonatal Sepsis Due to Multidrug-resistant Bacteria at a Tertiary Teaching Hospital in Ethiopia.
Mulatu Gashaw, Solomon Ali, Melkamu Berhane, Getnet Tesfaw, Beza Eshetu, Thomas Seeholzer

Pediatr Infect Dis J· July 2024

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Hospital Wastes as Potential Sources for Multi-Drug-Resistant ESBL-Producing Bacteria at a Tertiary Hospital in Ethiopia.
Mulatu Gashaw, Esayas Kebede Gudina, Wondwossen Tadesse, Guenter Froeschl, Solomon Ali, Thomas Seeholzer

Antibiotics (Basel)· April 2024

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Molecular characterization of carbapenem-resistance in Gram-negative isolates obtained from clinical samples at Jimma Medical Center, Ethiopia.
Mulatu Gashaw, Esayas Kebede Gudina, Solomon Ali, Liegl Gabriele, Thomas Seeholzer

Front Microbiol· January 2024

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Human T17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation.
Ying-Yin Chao, Alisa Puhach, David Frieser, Mahima Arunkumar, Laurens Lehner, Thomas Seeholzer

Nat Immunol· February 2023

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TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.
Thomas J O'Neill, Andreas Gewies, Thomas Seeholzer, Daniel Krappmann

Front Immunol· February 2023

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Phosphorylation of serine-893 in CARD11 suppresses the formation and activity of the CARD11-BCL10-MALT1 complex in T and B cells.
Kerstin Kutzner, Simone Woods, Ozge Karayel, Torben Gehring, Hongli Yin, Thomas Seeholzer

Sci Signal· March 2022

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A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.
Hongli Yin, Ozge Karayel, Ying-Yin Chao, Thomas Seeholzer, Isabel Hamp

Cell Mol Life Sci· January 2022

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TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.
Thomas J O'Neill, Thomas Seeholzer, Andreas Gewies, Torben Gehring, Florian Giesert

Sci Immunol· November 2021

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Human immune disorder associated with homozygous hypomorphic mutation affecting MALT1B splice variant.
Necil Kutukculer, Thomas Seeholzer, Thomas J O'Neill, Carina Graß, Ayca Aykut

J Allergy Clin Immunol· February 2021

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Use of Non-Natural Amino Acids for the Design and Synthesis of a Selective, Cell-Permeable MALT1 Activity-Based Probe.
Merel A T van de Plassche, Thomas J O'Neill, Thomas Seeholzer, Boris Turk, Daniel Krappmann

J Med Chem· April 2020

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BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation.
Thomas Seeholzer, Susanne Kurz, Florian Schlauderer, Simone Woods, Torben Gehring

Front Immunol· October 2019

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Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.
Jonathan J Cho, Zhiwei Xu, Upasana Parthasarathy, Theodore T Drashansky, Eric Y Helm, Thomas Seeholzer

Nat Commun· February 2019

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MALT1 activation by TRAF6 needs neither BCL10 nor CARD11.
Maureen Bardet, Thomas Seeholzer, Adeline Unterreiner, Simone Woods, Daniel Krappmann

Biochem Biophys Res Commun· November 2018

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Molecular architecture and regulation of BCL10-MALT1 filaments.
Florian Schlauderer, Thomas Seeholzer, Ambroise Desfosses, Torben Gehring, Mike Strauss

Nat Commun· October 2018

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BCL10 - Bridging CARDs to Immune Activation.
Torben Gehring, Thomas Seeholzer, Daniel Krappmann

Front Immunol· July 2018

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Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells.
Isabel Meininger, Richard A Griesbach, Desheng Hu, Torben Gehring, Thomas Seeholzer

Nat Commun· April 2016

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