Publications by authors named "Tiit Ord"

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The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium.
Andrey Anisimov, Shentong Fang, Karthik Amudhala Hemanthakumar, Tiit Örd, Kristof van Avondt, Raphael Chevre, Anu Toropainen, Prosanta Singha, Huda Gilani, Su D Nguyen

Nat Cardiovasc Res· March 2023

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Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis.
Tiit Örd, Senthil Palani, Judith Giroud Gerbetant, Susanna Bodoy, Tapio Lönnberg

Cardiovasc Res· December 2025

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AP-1 elements in the promoter and second intron mediate endoplasmic reticulum stress-induced expression of the GPAT3 gene.
Daima Örd, Tiit Örd, Elina Gluboki, Tõnis Örd

Sci Rep· December 2025

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MicroRNA gene dynamics in immune cell subpopulations during aging and atherosclerosis disease development at single-cell resolution.
Ana Hernández de Sande, Tanja Turunen, Maria Bouvy-Liivrand, Tiit Örd, Senthil Palani

Genome Med· October 2025

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Slc7a7 licenses macrophage glutaminolysis for restorative functions in atherosclerosis.
Saloua Benhmammouch, Coraline Borowczyk, Clara Pierrot-Blanchet, Thibault Barouillet, Florent Murcy

Nat Metab· September 2025

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Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy.
Emilia Happonen, Yijing Dang, Jiajia Wang, Silja Saarela, Minna Sivonen

ACS Appl Mater Interfaces· August 2025

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Mitochondrial ROS drive foam cell formation via STAT5 signaling in atherosclerosis.
Laura Boccuni, Frieda Marka, Manuel Salzmann, Alessia Schirripa, Elisabeth Ableitner

Sci Adv· August 2025

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Integrated ambient modeling and genetic demultiplexing of single-cell RNA+ATAC multiome experiments with Ambimux.
Marcus Alvarez, Terence Li, Seung Hyuk T Lee, Uma Thanigai Arasu, Ilakya Selvarajan

bioRxiv· August 2025

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Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques.
Katyayani Sukhavasi, Giuseppe Mocci, Lijiang Ma, Chani J Hodonsky, Ernest Diez Benevante

Nat Cardiovasc Res· April 2025

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Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease.
Seung Hyuk T Lee, Kristina M Garske, Uma Thanigai Arasu, Asha Kar, Zong Miao

EBioMedicine· August 2024

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Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis.
Aarthi Ravindran, Lari Holappa, Henri Niskanen, Ilya Skovorodkin, Susanna Kaisto

Cardiovasc Res· July 2024

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Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.
Ilakya Selvarajan, Miika Kiema, Ru-Ting Huang, Jin Li, Jiayu Zhu

Arterioscler Thromb Vasc Biol· June 2024

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Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis.
Giuseppe Mocci, Katyayani Sukhavasi, Tiit Örd, Sean Bankier, Prosanta Singha

Circ Res· May 2024

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Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease.
Suvi Linna-Kuosmanen, Eloi Schmauch, Kyriakitsa Galani, Johannes Ojanen, Carles A Boix

Cell Rep Med· May 2024

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Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations.
Rédouane Aherrahrou, Ferheen Baig, Konstantinos Theofilatos, Dillon Lue, Alicia Beele

Arterioscler Thromb Vasc Biol· April 2024

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Secreted protein profiling of human aortic smooth muscle cells identifies vascular disease associations.
Rédouane Aherrahrou, Ferheen Baig, Konstantinos Theofilatos, Dillon Lue, Alicia Beele

medRxiv· November 2023

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Colchicine promotes atherosclerotic plaque stability independently of inflammation.
Weizhen Li, Alexander Lin, Michael Hutton, Harkirat Dhaliwal, James Nadel

bioRxiv· October 2023

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Genome-wide census of ATF4 binding sites and functional profiling of trait-associated genetic variants overlapping ATF4 binding motifs.
Tiit Örd, Daima Örd, Priit Adler, Tõnis Örd

PLoS Genet· October 2023

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Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease.
Nicholas Darci-Maher, Marcus Alvarez, Uma Thanigai Arasu, Ilakya Selvarajan, Seung Hyuk T Lee

EBioMedicine· June 2023

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Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures.
Tiit Örd, Tapio Lönnberg, Valtteri Nurminen, Aarthi Ravindran, Henri Niskanen

Am J Hum Genet· May 2023

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ErbB signaling is a potential therapeutic target for vascular lesions with fibrous component.
Suvi Jauhiainen, Henna Ilmonen, Pia Vuola, Heta Rasinkangas, Heidi H Pulkkinen

Elife· May 2023

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Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity.
Sanna Kettunen, Anna-Kaisa Ruotsalainen, Tiit Örd, Tuisku Suoranta, Janne Heikkilä

Front Cardiovasc Med· March 2023

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Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes.
Rédouane Aherrahrou, Dillon Lue, R Noah Perry, Yonathan Tamrat Aberra, Mohammad Daud Khan

Circ Res· February 2023

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ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice.
Mohan Babu, Durga Devi, Petri Mäkinen, Tiit Örd, Einari Aavik

Arterioscler Thromb Vasc Biol· January 2023

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Corrigendum: Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2,4)-4-F-Fluoroglutamine.
Senthil Palani, Maxwell W G Miner, Jenni Virta, Heidi Liljenbäck, Olli Eskola

Front Immunol· April 2022

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