Publications by authors named "Timothy Frayling"

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Phantasia-The psychological significance of lifelong visual imagery vividness extremes.
Adam Zeman, Fraser Milton, Sergio Della Sala, Michaela Dewar, Timothy Frayling, James Gaddum, Andrew Hattersley, Brittany Heuerman-Williamson, Kealan Jones, Matthew MacKisack

Cortex· September 2020

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Getting to GRIPS with MR-Egger: Modelling directional pleiotropy independently of allele coding.
Frank Dudbridge, Bethany Voller, Ruby M Woodward, Katie L Saxby, Timothy M Frayling

PLoS Genet· December 2025

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Clinical utility of self-reported sleep duration and insomnia symptoms in type 2 diabetes prediction.
Alison K Wright, Tianyi Huang, Matthew J Carr, Arjun D Premdayal, Sushant Saluja, Timothy M Frayling

Diabetologia· November 2025

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Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Roelof A J Smit, Kaitlin H Wade, Qin Hui, Joshua D Arias, Xianyong Yin, Timothy M Frayling

Nat Med· September 2025

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Weight Management in a Patient With Smith-Magenis Syndrome: The Role of GLP-1 Receptor Agonists.
Jorge César Correia, Timothy Frayling, Zoltan Pataky

JCEM Case Rep· July 2025

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A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data.
Olivia Murrin, Ninon Mounier, Bethany Voller, Linus Tata, Carlos Gallego-Moll, Timothy M Frayling

EBioMedicine· March 2025

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Whole-genome sequencing analysis identifies rare, large-effect noncoding variants and regulatory regions associated with circulating protein levels.
Gareth Hawkes, Kartik Chundru, Leigh Jackson, Kashyap A Patel, Anna Murray, Timothy M Frayling

Nat Genet· March 2025

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Subclassification of obesity for precision prediction of cardiometabolic diseases.
Daniel E Coral, Femke Smit, Ali Farzaneh, Alexander Gieswinkel, Juan Fernandez Tajes, Timothy M Frayling

Nat Med· February 2025

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Author Correction: Subclassification of obesity for precision prediction of cardiometabolic diseases.
Daniel E Coral, Femke Smit, Ali Farzaneh, Alexander Gieswinkel, Juan Fernandez Tajes, Timothy M Frayling

Nat Med· February 2025

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Effects of childhood and adult height on later life cardiovascular disease risk estimated through Mendelian randomization.
Tom G Richardson, Helena Urquijo, Laurence J Howe, Gareth Hawkes, John DePaolo, Timothy M Frayling

Eur J Epidemiol· February 2025

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Using clustering of genetic variants in Mendelian randomization to interrogate the causal pathways underlying multimorbidity from a common risk factor.
Xiaoran Liang, Ninon Mounier, Nicolas Apfel, Sara Khalid, Timothy M Frayling

Genet Epidemiol· January 2025

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Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height.
Gareth Hawkes, Robin N Beaumont, Zilin Li, Ravi Mandla, Xihao Li, Timothy M Frayling

Nat Commun· October 2024

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The role of accelerometer-derived sleep traits on glycated haemoglobin and glucose levels: a Mendelian randomization study.
Junxi Liu, Rebecca C Richmond, Emma L Anderson, Jack Bowden, Ciarrah-Jane S Barry, Timothy M Frayling

Sci Rep· June 2024

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Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature review.
Grace M Power, Eleanor Sanderson, Panagiota Pagoni, Abigail Fraser, Tim Morris, Timothy M Frayling

Eur J Epidemiol· May 2024

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J Taylor, Xianyong Yin, Timothy M Frayling

Nature· March 2024

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Hyperglycaemia is a causal risk factor for upper limb pathologies.
Harry D Green, Ella Burden, Ji Chen, Jonathan Evans, Kashyap Patel, Timothy M Frayling

Int J Epidemiol· February 2024

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A Federated Database for Obesity Research: An IMI-SOPHIA Study.
Carl Delfin, Iulian Dragan, Dmitry Kuznetsov, Juan Fernandez Tajes, Femke Smit, Timothy M Frayling

Life (Basel)· February 2024

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Mediation and moderation of genetic risk of obesity through eating behaviours in two UK cohorts.
Shahina Begum, Eleanor C Hinton, Zoi Toumpakari, Timothy M Frayling, Laura Howe

Int J Epidemiol· December 2023

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Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review.
Rieneke van der Meer, Siham A Mohamed, Valerie M Monpellier, Ronald S L Liem, Eric J Hazebroek, Timothy M Frayling

Obes Rev· December 2023

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Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records.
Katherine S Ruth, Robin N Beaumont, Jonathan M Locke, Jessica Tyrrell, Carolyn J Crandall, Timothy M Frayling

BMC Med Genomics· October 2023

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Identification and analysis of individuals who deviate from their genetically-predicted phenotype.
Gareth Hawkes, Loic Yengo, Sailaja Vedantam, Eirini Marouli, Robin N Beaumont, Timothy M Frayling

PLoS Genet· September 2023

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Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.
Gareth Hawkes, Robin N Beaumont, Jessica Tyrrell, Grace M Power, Andrew Wood, Timothy M Frayling

Diabetologia· August 2023

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Genetic predisposition to metabolically unfavourable adiposity and prostate cancer risk: A Mendelian randomization analysis.
Aurora Perez-Cornago, Karl Smith-Byrne, Emma Hazelwood, Cody Z Watling, Susan Martin, Timothy Frayling

Cancer Med· August 2023

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Age-specific effects of weight-based body size on fracture risk in later life: a lifecourse Mendelian randomisation study.
Grace Marion Power, Jonathan H Tobias, Timothy M Frayling, Jessica Tyrrell, April E Hartley

Eur J Epidemiol· July 2023

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Author Correction: The power of genetic diversity in genome-wide association studies of lipids.
Sarah E Graham, Shoa L Clarke, Kuan-Han H Wu, Stavroula Kanoni, Greg J M Zajac, Timothy M Frayling

Nature· June 2023

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Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.
Alice Williamson, Dougall M Norris, Xianyong Yin, K Alaine Broadaway, Anne H Moxley, Timothy M Frayling

Nat Genet· June 2023

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