Publications by authors named "Timothy Shutt"

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Drug repurposing screen identifies an HRI activating compound that promotes adaptive mitochondrial remodeling in MFN2-deficient cells.
Prerona Bora, Mashiat Zaman, Samantha Oviedo, Sergei Kutseikin, Nicole Madrazo, Timothy E Shutt

Proc Natl Acad Sci U S A· December 2025

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Examination of mitochondria- and inflammasome-mediated mechanisms of clozapine-induced myocarditis using patient-derived iPSC cardiomyocytes.
Nazanin Vaziri, Timothy E Shutt, Wasi Karim, Thomas J Raedler, Christos Pantelis

Mol Psychiatry· August 2025

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The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation.
Mashiat Zaman, Govinda Sharma, Walaa Almutawa, Tyler Gb Soule, Rasha Sabouny, Timothy E Shutt

Life Sci Alliance· June 2025

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Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells.
Prerona Bora, Mashiat Zaman, Samantha Oviedo, Sergei Kutseikin, Nicole Madrazo, Timothy E Shutt

bioRxiv· June 2025

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Validating the Genus Pocheina (Acrasidae, Heterolobosea, Discoba) Leads to the Recognition of Three Major Lineages Within Acrasidae.
Alexander K Tice, Kevin Regis, Timothy E Shutt, Frederick W Spiegel, Matthew W Brown

J Eukaryot Microbiol· May 2025

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Mitochondria - the CEO of the cell.
Laurie P Lee-Glover, Martin Picard, Timothy E Shutt

J Cell Sci· May 2025

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Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation.
Kelsey R Baron, Samantha Oviedo, Sophia Krasny, Mashiat Zaman, Rama Aldakhlallah, Timothy E Shutt

Elife· February 2025

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Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation.
Kelsey R Baron, Samantha Oviedo, Sophia Krasny, Mashiat Zaman, Rama Aldakhlallah, Timothy E Shutt

bioRxiv· November 2024

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Mitochondrial DNA release and sensing in innate immune responses.
Jordyn J VanPortfliet, Cole Chute, Yuanjiu Lei, Timothy E Shutt, A Phillip West

Hum Mol Genet· May 2024

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Valosin-Containing Protein (VCP): A Review of Its Diverse Molecular Functions and Clinical Phenotypes.
Carly S Pontifex, Mashiat Zaman, Roberto D Fanganiello, Timothy E Shutt, Gerald Pfeffer

Int J Mol Sci· May 2024

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Mitochondrial quality control pathways sense mitochondrial protein import.
Laurie P Lee-Glover, Timothy E Shutt

Trends Endocrinol Metab· April 2024

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Characterization of a novel variant in the HR1 domain of in a patient with ataxia, optic atrophy and sensorineural hearing loss.
Govinda Sharma, Mashiat Zaman, Rasha Sabouny, Matthew Joel, Kristina Martens, Timothy E Shutt

F1000Res· February 2024

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Potentiation of Adipogenesis by Reactive Oxygen Species Is a Unifying Mechanism in the Proadipogenic Properties of Bisphenol A and Its New Structural Analogues.
Radha D Singh, Jessica L Wager, Taylor B Scheidl, Liam T Connors, Sarah Easson, Timothy E Shutt

Antioxid Redox Signal· January 2024

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Butyrate reduces adherent-invasive -evoked disruption of epithelial mitochondrial morphology and barrier function: involvement of free fatty acid receptor 3.
Samira A Hamed, Armaan Mohan, Saranya Navaneetha Krishnan, Arthur Wang, Marija Drikic, Timothy E Shutt

Gut Microbes· December 2023

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Postictal hypoxia involves reactive oxygen species and is ameliorated by chronic mitochondrial uncoupling.
Bianca R Villa, Antis G George, Timothy E Shutt, Patrick G Sullivan, Jong M Rho

Neuropharmacology· November 2023

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Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT.
Iman Al Khatib, Jingti Deng, Yuanjiu Lei, Sylvia Torres-Odio, Gladys R Rojas, Timothy E Shutt

Hum Mol Genet· July 2023

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Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Yuanjiu Lei, Jordyn J VanPortfliet, Yi-Fan Chen, Joshua D Bryant, Ying Li, Timothy E Shutt

Cell· July 2023

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Tissue imaging reveals disruption of epithelial mitochondrial networks and loss of mitochondria-associated cytochrome-C in inflamed human and murine colon.
Andrew K Chojnacki, Saranya Navaneetha Krishnan, Humberto Jijon, Timothy E Shutt, Pina Colarusso

Mitochondrion· January 2023

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Functional characterization of two variants of mitochondrial topoisomerase TOP1MT that impact regulation of the mitochondrial genome.
Iman Al Khatib, Jingti Deng, Andrew Symes, Marina Kerr, Hongliang Zhang, Timothy E Shutt

J Biol Chem· October 2022

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Impact of experimental colitis on mitochondrial bioenergetics in intestinal epithelial cells.
Luke Goudie, Nicole L Mancini, Timothy E Shutt, Graham P Holloway, Chunlong Mu

Sci Rep· May 2022

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Mitochondrial Protein Homeostasis and Cardiomyopathy.
Emily Wachoski-Dark, Tian Zhao, Aneal Khan, Timothy E Shutt, Steven C Greenway

Int J Mol Sci· March 2022

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The Role of Impaired Mitochondrial Dynamics in MFN2-Mediated Pathology.
Mashiat Zaman, Timothy E Shutt

Front Cell Dev Biol· March 2022

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The role of protein acetylation in regulating mitochondrial fusion and fission.
Golam M Uddin, Rafa Abbas, Timothy E Shutt

Biochem Soc Trans· December 2021

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The role of mitochondrial dynamics in mtDNA maintenance.
Rasha Sabouny, Timothy E Shutt

J Cell Sci· December 2021

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A new automated tool to quantify nucleoid distribution within mitochondrial networks.
Hema Saranya Ilamathi, Mathieu Ouellet, Rasha Sabouny, Justine Desrochers-Goyette, Matthew A Lines, Timothy E Shutt

Sci Rep· November 2021

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