Publications by authors named "Vincent Njar"

Claim this Profile
T
Thermal proteome profiling and proteome analysis using high-definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next-generation galeterone analog VNPP433-3β in castration-resistant prostate cancer.
Retheesh S Thankan, Elizabeth Thomas, Mehari M Weldemariam, Puranik Purushottamachar, Weiliang Huang, Vincent C O Njar

Mol Oncol· August 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correction: Maranto et al. Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo. 2020, , 3412.
Cristina Maranto, Vindhya Udhane, Jing Jia, Ranjit Verma, Gerhard Müller-Newen, Vincent C O Njar

Cancers (Basel)· March 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Sterol-like drugs potentiate statin-triggered prostate cancer cell death by inhibiting SREBP2 nuclear translocation.
Diandra Zipinotti Dos Santos, Mohamad Elbaz, Emily Branchard, Wiebke Schormann, Carla E Brown, Vincent C O Njar

Biomed Pharmacother· August 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Salinization Dramatically Enhance the Anti-Prostate Cancer Efficacies of AR/AR-V7 and Mnk1/2 Molecular Glue Degraders, Galeterone and VNPP433-3β Which Outperform Docetaxel and Enzalutamide in CRPC CWR22Rv1 Xenograft Mouse Model.
Retheesh S Thankan, Elizabeth Thomas, Puranik Purushottamachar, David J Weber, Vincent C O Njar

Bioorg Chem· October 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
V
VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins and by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2.
Retheesh S Thankan, Elizabeth Thomas, Puranik Purushottamachar, David J Weber, Vidya P Ramamurthy, Vincent C O Njar

Front Oncol· September 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Murine toxicology and pharmacokinetics of lead next generation galeterone analog, VNPP433-3β.
Elizabeth Thomas, Retheesh S Thankan, Puranik Purushottamachar, Jianxia Guo, Robert A Parise, Vincent C O Njar

Steroids· April 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Targeted Degradation of Androgen Receptor by VNPP433-3β in Castration-Resistant Prostate Cancer Cells Implicates Interaction with E3 Ligase MDM2 Resulting in Ubiquitin-Proteasomal Degradation.
Elizabeth Thomas, Retheesh S Thankan, Puranik Purushottamachar, David J Weber, Vincent C O Njar

Cancers (Basel)· February 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Large-scale synthesis of galeterone and lead next generation galeterone analog VNPP433-3β.
Puranik Purushottamachar, Elizabeth Thomas, Retheesh S Thankan, Vladimir Rudchenko, Guangfei Huang, Vincent C O Njar

Steroids· September 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel deuterated Mnk1/2 protein degrader VNLG-152R analogs: Synthesis, In vitro Anti-TNBC activities and pharmacokinetics in mice.
Puranik Purushottamachar, Elizabeth Thomas, Retheesh S Thankan, Vincent C O Njar

Eur J Med Chem· August 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel AR/AR-V7 and Mnk1/2 Degrader, VNPP433-3β: Molecular Mechanisms of Action and Efficacy in AR-Overexpressing Castration Resistant Prostate Cancer In Vitro and In Vivo Models.
Elizabeth Thomas, Retheesh S Thankan, Puranik Purushottamachar, Weiliang Huang, Maureen A Kane, Vincent C O Njar

Cells· August 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Transcriptome profiling reveals that VNPP433-3β, the lead next-generation galeterone analog inhibits prostate cancer stem cells by downregulating epithelial-mesenchymal transition and stem cell markers.
Elizabeth Thomas, Retheesh S Thankan, Puranik Purushottamachar, Weiliang Huang, Maureen A Kane, Vincent C O Njar

Mol Carcinog· July 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo.
Cristina Maranto, Vindhya Udhane, Jing Jia, Ranjit Verma, Gerhard Müller-Newen, Vincent C O Njar

Cancers (Basel)· November 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo.
Andrew K Kwegyir-Afful, Senthilmurugan Ramalingam, Vidya P Ramamurthy, Puranik Purushottamachar, Francis N Murigi, Vincent C O Njar

Cancers (Basel)· October 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis.
Senthilmurugan Ramalingam, Vidya P Ramamurthy, Lalji K Gediya, Francis N Murigi, Puranik Purushottamachar, Vincent C O Njar

Cancers (Basel)· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The retinamide VNLG-152 inhibits f-AR/AR-V7 and MNK-eIF4E signaling pathways to suppress EMT and castration-resistant prostate cancer xenograft growth.
Vidya P Ramamurthy, Senthilmurugan Ramalingam, Lalji K Gediya, Vincent C O Njar

FEBS J· March 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy.
Vincent C O Njar

Transl Cancer Res· October 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel galeterone analogs act independently of AR and AR-V7 for the activation of the unfolded protein response and induction of apoptosis in the CWR22Rv1 prostate cancer cell model.
David J McCarty, Weiliang Huang, Maureen A Kane, Puranik Purushottamachar, Lalji K Gediya, Vincent C O Njar

Oncotarget· October 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice.
Andrew K Kwegyir-Afful, Francis N Murigi, Puranik Purushottamachar, Vidya P Ramamurthy, Marlena S Martin, Vincent C O Njar

Oncotarget· August 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Targeting of protein translation as a new treatment paradigm for prostate cancer.
Vidya P Ramamurthy, Senthilmurugan Ramalingam, Andrew K Kwegyir-Afful, Arif Hussain, Vincent C O Njar

Curr Opin Oncol· May 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Dissecting major signaling pathways in prostate cancer development and progression: Mechanisms and novel therapeutic targets.
Senthilmurugan Ramalingam, Vidya P Ramamurthy, Vincent C O Njar

J Steroid Biochem Mol Biol· February 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Letter to the editor.
Vincent C O Njar

Expert Opin Ther Targets· January 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Galeterone and VNPT55 disrupt Mnk-eIF4E to inhibit prostate cancer cell migration and invasion.
Andrew K Kwegyir-Afful, Robert D Bruno, Puranik Purushottamachar, Francis N Murigi, Vincent C O Njar

FEBS J· November 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Vincent Co Njar

Autophagy· October 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of Novel Steroidal Androgen Receptor Degrading Agents Inspired by Galeterone 3β-Imidazole Carbamate.
Puranik Purushottamachar, Andrew K Kwegyir-Afful, Marlena S Martin, Vidya P Ramamurthy, Senthilmurugan Ramalingam, Vincent C O Njar

ACS Med Chem Lett· July 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo.
Andrew K Kwegyir-Afful, Senthilmurugan Ramalingam, Puranik Purushottamachar, Vidya P Ramamurthy, Vincent C O Njar

Oncotarget· September 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis