Publications by authors named "Vinothini Rajeeve"

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Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes.
Pedro Casado, Ana Rio-Machin, Juho J Miettinen, Findlay Bewicke-Copley, Kevin Rouault-Pierre, Szilvia Krizsan, Alun Parsons, Vinothini Rajeeve, Farideh Miraki-Moud, David C Taussig

Signal Transduct Target Ther· February 2023

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A novel inhibitor of soluble epoxide hydrolase that adducts C521 is cardioprotective.
Rebecca L Charles, Mariana Fernandez-Caggiano, Olena Rudyk, Izaak Tyson-Hirst, Mazdak Ehteramyan, Vinothini Rajeeve

Redox Biol· December 2025

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HMMR has oncoprotein-like properties in neuroblastoma cells and high HMMR expression has independent prognostic potential in neuroblastomas.
Christina Karapouliou, Elisyazaviera M Faizul, Vinothini Rajeeve, Pedro R Cutillas, Andrew W Stoker

Sci Rep· November 2025

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SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2.
Hyun-Ju Cho, Joy Smith, Christopher H Switzer, Eleni Louka, Rebecca L Charles, Vinothini Rajeeve

EMBO Mol Med· August 2025

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RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation.
Alejandro Rosell, Agata Adelajda Krygowska, Marta Alcón Pérez, Cristina Cuesta, Mathieu-Benoit Voisin, Vinothini Rajeeve

Elife· April 2025

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Phosphoproteomics identifies determinants of PAK inhibitor sensitivity in leukaemia cells.
Pedro Casado, Santiago Marfa, Marym M Hadi, Henry Gerdes, Sandra M Martin-Guerrero, Vinothini Rajeeve

Cell Commun Signal· March 2025

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Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes.
Cankut Çubuk, Rachel Lau, Pedro Cutillas, Vinothini Rajeeve, Christopher R John

Arthritis Res Ther· June 2024

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Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate.
Priyanka Hirani, Jacqueline McDermott, Vinothini Rajeeve, Pedro R Cutillas, J Louise Jones

Cancer Res Commun· April 2024

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Efferocyte-Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1-Mediated Activation of Glycolysis.
Duco Steven Koenis, Roberta de Matteis, Vinothini Rajeeve, Pedro Cutillas, Jesmond Dalli

Adv Sci (Weinh)· February 2024

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SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML.
Antonella Di Mambro, Yoana Arroyo-Berdugo, Tiziana Fioretti, Michael Randles, Luca Cozzuto, Vinothini Rajeeve

Oncogene· December 2023

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Proximity proteomics identifies septins and PAK2 as decisive regulators of actomyosin-mediated expulsion of von Willebrand factor.
Sammy El-Mansi, Christopher L Robinson, Katja B Kostelnik, Jessica J McCormack, Tom P Mitchell, Vinothini Rajeeve

Blood· February 2023

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The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells.
Elliott M Thompson, Vruti Patel, Vinothini Rajeeve, Pedro R Cutillas, Andrew W Stoker

FEBS Open Bio· July 2022

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eEF2K Activity Determines Synergy to Cotreatment of Cancer Cells With PI3K and MEK Inhibitors.
Maruan Hijazi, Pedro Casado, Nosheen Akhtar, Saul Alvarez-Teijeiro, Vinothini Rajeeve

Mol Cell Proteomics· June 2022

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Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment.
Marina Roy-Luzarraga, Louise E Reynolds, Beatriz de Luxán-Delgado, Oscar Maiques, Laura Wisniewski, Vinothini Rajeeve

Cancer Res· May 2022

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MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis.
Kimberly Pistorius, Lucy Ly, Patricia R Souza, Esteban A Gomez, Duco S Koenis, Vinothini Rajeeve

EBioMedicine· May 2022

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Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth.
Emma Newport, Ana Rita Pedrosa, Delphine Lees, Matthew Dukinfield, Edward Carter, Vinothini Rajeeve

J Pathol· February 2022

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Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion.
Elizabeth R Murray, Shinelle Menezes, Jack C Henry, Josie L Williams, Lorena Alba-Castellón, Vinothini Rajeeve

Cell Rep· January 2022

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Computational Analysis of Cholangiocarcinoma Phosphoproteomes Identifies Patient-Specific Drug Targets.
Shirin Elizabeth Khorsandi, Arran D Dokal, Vinothini Rajeeve, David J Britton, Megan S Illingworth

Cancer Res· November 2021

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TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer.
Laura S M Lecker, Chiara Berlato, Eleni Maniati, Robin Delaine-Smith, Oliver M T Pearce, Vinothini Rajeeve

Cancer Res· November 2021

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Correction to 'Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma'.
Verónica Freire-Benéitez, Nicola Pomella, Thomas O Millner, Anaëlle A Dumas, Maria Victoria Niklison-Chirou, Vinothini Rajeeve

NAR Cancer· June 2021

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Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs.
Henry Gerdes, Pedro Casado, Arran Dokal, Maruan Hijazi, Nosheen Akhtar, Vinothini Rajeeve

Nat Commun· March 2021

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Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.
Verónica Freire-Benéitez, Nicola Pomella, Thomas O Millner, Anaëlle A Dumas, Maria Victoria Niklison-Chirou, Vinothini Rajeeve

NAR Cancer· March 2021

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Sequence and Structure-Based Analysis of Specificity Determinants in Eukaryotic Protein Kinases.
David Bradley, Cristina Viéitez, Vinothini Rajeeve, Joel Selkrig, Pedro R Cutillas

Cell Rep· January 2021

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PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability.
Sandra M Martín-Guerrero, Pedro Casado, Maruan Hijazi, Vinothini Rajeeve, Julio Plaza-Díaz

Biochem J· December 2020

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FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer.
Sonia Zaghdoudi, Emilie Decaup, Ismahane Belhabib, Rémi Samain, Stéphanie Cassant-Sourdy, Vinothini Rajeeve

EMBO Mol Med· November 2020

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