Publications by authors named "William Tepp"

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Botulinum neurotoxin Light Chain/A1 uses fast synaptic vesicle cycling to cleave plasma membrane bound SNAP-25.
Alexander Gardner, Molly Sneller, William H Tepp, Joseph T Barbieri, Sabine Pellett

Commun Biol· September 2025

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Bifunctional Inhibition of Botulinum Neurotoxin A Protease: Unexpected Active Site Inhibition Enhances Covalent Targeting of an Allosteric Site.
Mingliang Lin, Nishant Karadkhelkar, Yanjie Li, Lisa M Eubanks, William H Tepp

J Med Chem· April 2025

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Expression of Recombinant Clostridial Neurotoxin by .
Brieana M Gregg, Sonal Gupta, William H Tepp, Sabine Pellett

Microorganisms· December 2024

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Investigations of Thiosemicarbazides as Botulinum Toxin Active-Site Inhibitors: Enzyme, Cellular, and Rodent Intoxication Studies.
Ealin N Patel, Lucy Lin, Hyeri Park, Molly M Sneller, Lisa M Eubanks, William H Tepp

ACS Infect Dis· November 2024

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Potency Evaluations of Recombinant Botulinum Neurotoxin A1 Mutants Designed to Reduce Toxicity.
Polrit Viravathana, William H Tepp, Marite Bradshaw, Amanda Przedpelski, Joseph T Barbieri

Int J Mol Sci· August 2024

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Botulinum neurotoxin X lacks potency in mice and in human neurons.
Brieana M Gregg, Takuhiro Matsumura, Travis G Wentz, William H Tepp, Marite Bradshaw

mBio· March 2024

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Botulinum Neurotoxin A4 Has a 1000-Fold Reduced Potency Due to Three Single Amino Acid Alterations in the Protein Receptor Binding Domain.
William H Tepp, Marite Bradshaw, Alexander P Gardner, Rebecca L Kaufman, Joseph T Barbieri

Int J Mol Sci· March 2023

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Transformation of a Metal Chelate into a "Catch and Anchor" Inhibitor of Botulinum A Protease.
Lucy Lin, Ealin N Patel, Alexander L Nielsen, Lewis D Turner, William H Tepp

Int J Mol Sci· February 2023

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Genomic Diversity, Competition, and Toxin Production by Group I and II Strains Used in Food Challenge Studies.
Brooke Kathryn Bowe, Travis Gwynn Wentz, Brieana Marie Gregg, William Howard Tepp, Kristin Marie Schill

Microorganisms· September 2022

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Investigation of Salicylanilides as Botulinum Toxin Antagonists.
Ealin N Patel, Lucy Lin, Molly M Sneller, Lisa M Eubanks, William H Tepp

ACS Infect Dis· August 2022

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Resolution of Two Steps in Botulinum Neurotoxin Serotype A1 Light Chain Localization to the Intracellular Plasma Membrane.
Alexander Gardner, William H Tepp, Marite Bradshaw, Joseph T Barbieri, Sabine Pellett

Int J Mol Sci· October 2021

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Posttranslational Regulation of Botulinum Neurotoxin Production in Clostridium botulinum Hall A-.
Heather N'te Inzalaco, William H Tepp, Chase Fredrick, Marite Bradshaw, Eric A Johnson

mSphere· August 2021

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A Novel High-Potency Tetanus Vaccine.
Amanda Przedpelski, William H Tepp, Sabine Pellett, Eric A Johnson, Joseph T Barbieri

mBio· August 2020

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Critical Analysis of Neuronal Cell and the Mouse Bioassay for Detection of Botulinum Neurotoxins.
Sabine Pellett, William H Tepp, Eric A Johnson

Toxins (Basel)· December 2019

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Comparative functional analysis of mice after local injection with botulinum neurotoxin A1, A2, A6, and B1 by catwalk analysis.
Molly S Moritz, William H Tepp, Heather N'te Inzalaco, Eric A Johnson, Sabine Pellett

Toxicon· September 2019

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Botulinum neurotoxins A, B, C, E, and F preferentially enter cultured human motor neurons compared to other cultured human neuronal populations.
Sabine Pellett, William H Tepp, Eric A Johnson

FEBS Lett· September 2019

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Isolation and Characterization of the Novel Botulinum Neurotoxin A Subtype 6.
Molly S Moritz, William H Tepp, Marite Bradshaw, Eric A Johnson, Sabine Pellett

mSphere· October 2018

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Substrate cleavage and duration of action of botulinum neurotoxin type FA ("H, HA").
Sabine Pellett, William H Tepp, Guangyun Lin, Eric A Johnson

Toxicon· June 2018

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The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes.
Sabine Pellett, Marite Bradshaw, William H Tepp, Christina L Pier, Regina C M Whitemarsh

mBio· March 2018

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Enhancing toxin-based vaccines against botulism.
Amanda Przedpelski, William H Tepp, Madison Zuverink, Eric A Johnson, Sabine Pellet

Vaccine· February 2018

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Assessment of ELISA as endpoint in neuronal cell-based assay for BoNT detection using hiPSC derived neurons.
Sabine Pellett, William H Tepp, Eric A Johnson, Dorothea Sesardic

J Pharmacol Toxicol Methods· November 2017

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Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC.
Sicai Zhang, Ronnie P-A Berntsson, William H Tepp, Liang Tao, Eric A Johnson

Nat Commun· November 2017

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Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.
Alan R Jacobson, Michael Adler, Nicholas R Silvaggi, Karen N Allen, Genessa M Smith, William H Tepp

Toxicon· October 2017

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Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.
Paul T Bremer, Sabine Pellett, James P Carolan, William H Tepp, Lisa M Eubanks

J Am Chem Soc· May 2017

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Interneuronal Transfer and Distal Action of Tetanus Toxin and Botulinum Neurotoxins A and D in Central Neurons.
Ewa Bomba-Warczak, Jason D Vevea, Joel M Brittain, Annette Figueroa-Bernier, William H Tepp

Cell Rep· August 2016

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