Publications by authors named "YouFu Luo"

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Discovery of potent ClpX modulators with pronounced antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).
Yan Liu, Jin Li, Yucheng Ma, Wenfang Gao, Yuanlong Li, Baozhu Luo, Youfu Luo

Eur J Med Chem· January 2026

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A shape complementarity strategy based on NCA029 enables potent HsClpP agonists for the treatment of small cell lung carcinoma.
Linjie Li, Baozhu Luo, Xudong Wang, Zhongyu Jian, Hong Liu, Youfu Luo

Eur J Med Chem· December 2025

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Correction to "Rational Design of a Novel Class of Human ClpP Agonists through Ring-Opening Strategy with Enhanced Antileukemia Activity".
Xinrong Xiang, Zhengyi Dai, Baozhu Luo, Ninglin Zhao, Song Liu, Youfu Luo

J Med Chem· December 2025

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Polystyrene nanoplastics promote fish iridovirus replication via inducing inflammatory response, antioxidant damage and enhancing viral entry.
Mengke Liu, Linyong Zhi, Xinyi Ren, Youfu Luo, Qiwei Qin

Environ Pollut· December 2025

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Four Isosteroidal Alkaloids from Fritillaria Alleviate Lipopolysaccharide-Induced Inflammation in vitro and in vivo through MyD88- and TRIF-Dependent Signaling Pathways.
Er-Bu Aga, Ming-Xin Pai, Meng-Rui Zhang, Wai Ming Tse, Kathy Wai Gaun Tse, You-Fu Luo

Chin J Integr Med· November 2025

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Host-directed therapeutic targets in macrophages and their ligands against mycobacteria tuberculosis.
Jin Li, Yanmei Wang, Lei He, Luchuan Yang, Tao Tao, Youfu Luo

Infect Immun· October 2025

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Recent advances in the design of small molecules targeting human ClpP.
Ziyi Shu, Jiangnan Zhang, Yi Wu, Tao Yang, Youfu Luo

Future Med Chem· October 2025

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The mitochondrial protease ClpP is a promising target for multiple myeloma treatment.
Xiang Liu, Jinlong Gu, Song Liu, Jingcao Huang, Linfeng Li, Hongmei Luo, Youfu Luo

Biochem Pharmacol· June 2025

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Synthetic approaches and therapeutic applications of FDA-approved antibacterial agents: A comprehensive review from 2003 to 2023.
Wenliang Qiao, Lijiao Wang, Youfu Luo, Tao Yang

Eur J Med Chem· March 2025

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Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4 T cell for inflammatory bowel diseases treatment.
Jiangnan Zhang, Yunhan Jiang, Dongmei Fan, Zhiqiang Qiu, Xinlian He, Youfu Luo

Cell Rep Med· December 2024

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STATs, promising targets for the treatment of autoimmune and inflammatory diseases.
Xinlian He, Pingxian Liu, Youfu Luo, Xinyuan Fu, Tao Yang

Eur J Med Chem· November 2024

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Integrating computational and experimental approaches in discovery and validation of MmpL3 pore domain inhibitors for specific labelling of Mycobacterium tuberculosis.
Yuanzheng Zhou, Zhiqiang Qiu, Baoyu Dong, Yang Yang, Qiantao Wang, Youfu Luo

Int J Biol Macromol· November 2024

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Patenting perspective of modulators of ClpP endopeptidase: 2019-present.
Zhenyu Wang, Liqing He, Ziheng Fan, Youfu Luo

Expert Opin Ther Pat· November 2024

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Advancing Tumor-Targeted Chemo-Immunotherapy: Development of the CAR-M-derived Exosome-Drug Conjugate.
Yunhan Jiang, Xiaoqiu Xu, Dongmei Fan, Pingxian Liu, Meng Zhou, Youfu Luo

J Med Chem· August 2024

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In vitro and in vivo enhancement effect of glabridin on the antibacterial activity of colistin, against multidrug resistant Escherichia coli strains.
Jiaxing Yang, Laiying Zhang, Xinlian He, Xupeng Gou, Zhiyong Zong, Youfu Luo

Phytomedicine· July 2024

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Discovery of 5-(Piperidin-4-yl)-1,2,4-oxadiazole Derivatives as a New Class of Human Caseinolytic Protease P Agonists for the Treatment of Hepatocellular Carcinoma.
Song Liu, Jing Sui, Baozhu Luo, Jiangnan Zhang, Xinrong Xiang, Youfu Luo

J Med Chem· July 2024

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Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level.
Lidan Zhang, Pingxian Liu, Yunhan Jiang, Dongmei Fan, Xinlian He, Baozhu Luo, Youfu Luo

Eur J Med Chem· June 2024

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Discovery and Optimization of Novel FabI Inhibitors as Specific Therapeutic Agents for MRSA Infection.
Laiying Zhang, Jiaxing Yang, Xin Xu, Jiangnan Zhang, Zhiqiang Qiu, Baozhu Luo, Youfu Luo

J Med Chem· June 2024

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Application of covalent modality in proximity-induced drug pharmacology: Early development, current strategy, and feature directions.
Linjie Li, Song Liu, Youfu Luo

Eur J Med Chem· May 2024

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Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity.
Xinrong Xiang, Zhengyi Dai, Baozhu Luo, Ninglin Zhao, Song Liu, Youfu Luo

J Med Chem· April 2024

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Design, Synthesis, and Biological Evaluation of 5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine (AF-353) Derivatives as Novel DHFR Inhibitors against .
Zongkai Huang, Xupeng Gou, Xudong Hang, Ting Shi, Jiaxing Yang, Youfu Luo

J Med Chem· March 2024

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Discovery of a Novel Series of Caseinolytic Protease P Agonists for Colorectal Adenocarcinoma Treatment via ATF3-Dependent Integrated Stress Response.
Jiangnan Zhang, Zhiqiang Qiu, Song Liu, Jiasheng Huang, Baozhu Luo, Youfu Luo

J Med Chem· February 2024

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Facilitating the development of molecular glues: Opportunities from serendipity and rational design.
Weiqing Jiang, Yunhan Jiang, Youfu Luo, Wenliang Qiao, Tao Yang

Eur J Med Chem· January 2024

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Repurposing TAK875 as a novel STAT3 inhibitor for treating inflammatory bowel disease.
Xinlian He, Xupeng Gou, Dongmei Fan, Jiaxing Yang, Xinyuan Fu, Youfu Luo

Biochem Pharmacol· January 2024

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Discovery and Mechanistic Study of Novel ClpP1P2 Inhibitors.
Yang Yang, Ninglin Zhao, Xin Xu, Yuanzheng Zhou, Baozhu Luo, Youfu Luo

J Med Chem· December 2023

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