Publications by authors named "Yu-yan Cheng"

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Design, Synthesis, and Biological Evaluation of 3,4-Dihydroisoquinolin-1()-one Derivatives as Protein Arginine Methyltransferase 5 Inhibitors for the Treatment of Non-Hodgkin's Lymphoma.
Qing-Qing Li, Xu Quan, Zi-Xuan Wang, Nuo Qiao, Xing-Feng Ni, Yan-Cheng Yu

J Med Chem· January 2025

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Discovery of SILA-123 as a Highly Potent FLT3 Inhibitor for the Treatment of Acute Myeloid Leukemia with Various FLT3 Mutations.
Tian-Hua Wei, Zi-Xuan Wang, Meng-Yi Lu, Yu-Jing Xu, Jin Yang, Yang Cheng, Yan-Cheng Yu

J Med Chem· December 2024

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Design, Synthesis, and Biological Activities Evaluation of Type I FLT3 Inhibitors for the Treatment of Acute Myeloid Leukemia.
Jin Yang, Yan Zhang, Yue-Chu Li, Qing-Xin Wang, Meng-Yuan Zhang, Yan-Cheng Yu

Drug Dev Res· December 2024

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Kinase-Bench: Comprehensive Benchmarking Tools and Guidance for Achieving Selectivity in Kinase Drug Discovery.
Tian-Hua Wei, Shuang-Shuang Zhou, Xiao-Long Jing, Jia-Chuan Liu, Meng Sun, Cheng-Xiao Ling, Yan-Cheng Yu

J Chem Inf Model· December 2024

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Discovery of 1-(Phenylsulfonyl)-1,2,3,4-tetrahydroquinoline Derivative as Orally Bioavailable and Safe RORγt Inverse Agonists for Potential Treatment of Rheumatoid Arthritis.
Shan-Liang Sun, Hong-Jiang Xu, Xiao-Long Jiang, Jian Zhou, Wei Shi, Yan-Cheng Yu

J Med Chem· November 2024

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Exploring drug repositioning possibilities of kinase inhibitors via molecular simulation.
Qing-Xin Wang, Jiao Cai, Zi-Jun Chen, Jia-Chuan Liu, Jing-Jing Wang, Yan-Cheng Yu

Mol Inform· September 2024

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Research strategies of small molecules as chemotherapeutics to overcome multiple myeloma resistance.
Jin Yang, Yan-Cheng Yu, Zi-Xuan Wang, Qing-Qing Li, Ning Ding

Eur J Med Chem· May 2024

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Correction to "Discovery of RORγ Allosteric Fluorescent Probes and Their Application: Fluorescence Polarization, Screening, and Bioimaging".
Yan-Cheng Yu, Zhen-Jiang Tong, Xiao-Ting Liang, Jia-Zhen Wu, Yu-Jing Xu

J Med Chem· April 2024

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Discovery of RORγ Allosteric Fluorescent Probes and Their Application: Fluorescence Polarization, Screening, and Bioimaging.
Yan-Cheng Yu, Zhen-Jiang Tong, Xiao-Ting Liang, Jia-Zhen Wu, Yu-Jing Xu

J Med Chem· March 2024

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Unraveling the Promise of RET Inhibitors in Precision Cancer Therapy by Targeting RET Mutations.
Zi-Xuan Wang, Qing-Qing Li, Jiao Cai, Jia-Zhen Wu, Jing-Jing Wang, Yan-Cheng Yu

J Med Chem· March 2024

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Design and synthesis 1H-Pyrrolo[2,3-b]pyridine derivatives as FLT3 inhibitors for the treatment of Acute myeloid Leukemia.
Tian-Hua Wei, Yun Zhou, Jin Yang, Meng-Yuan Zhang, Jing-Jing Wang, Yan-Cheng Yu

Bioorg Med Chem· February 2024

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Preclinical characterization of danatinib as a novel FLT3 inhibitor with excellent efficacy against resistant acute myeloid leukemia.
Shan-Liang Sun, Jia-Zhen Wu, Jing-Jing Wang, Hai Zhou, Chen-Qian Zhang, Yan-Cheng Yu

Biomed Pharmacother· December 2023

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Natural products as potential lead compounds to develop new antiviral drugs over the past decade.
Jing-Han Zhao, Yue-Wei Wang, Jin Yang, Zhen-Jiang Tong, Jia-Zhen Wu, Yan-Cheng Yu

Eur J Med Chem· November 2023

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Challenges for the development of mutant isocitrate dehydrogenases 1 inhibitors to treat glioma.
Qing-Xin Wang, Peng-Yu Zhang, Qing-Qing Li, Zhen-Jiang Tong, Jia-Zhen Wu, Yan-Cheng Yu

Eur J Med Chem· September 2023

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Discovery of 4-(4-aminophenyl)-6-phenylisoxazolo[3,4-b]pyridine-3-amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia.
Qing-Xin Wang, Yi-Bo Wang, Jiu-Kai Sha, Hai Zhou, Jia-Chuan Liu, Yan-Cheng Yu

Drug Dev Res· April 2023

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Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II.
Qing-Xin Wang, Yu-Hao Cao, Li-Jin Yang, Yi-Yuan Ma, Nan Li, Yan-Cheng Yu

Future Med Chem· January 2023

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Do Executive Dysfunction, Delay Aversion, and Time Perception Deficit Predict ADHD Symptoms and Early Academic Performance in Preschoolers.
Que Zheng, Yu Yan Cheng, Edmund Sonuga-Barke, Kathy Kar-Man Shum

Res Child Adolesc Psychopathol· November 2022

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Synthesis and biological evaluation of 4-(4-aminophenyl)-6-methylisoxazolo[3,4-b] pyridin-3-amine covalent inhibitors as potential agents for the treatment of acute myeloid leukemia.
Ji-Bo Kang, Lu Chen, Xue-Jiao Leng, Jing-Jing Wang, Yang Cheng, Yan-Cheng Yu

Bioorg Med Chem· September 2022

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Reliability of Sonography-based Volume Computer Aided Diagnosis in the Normal Fetal Heart.
Wan Yu Hu, Yan Cheng Yu, Li Ya Dai, Shi Yan Li, Bo Wen Zhao

J Ultrasound Med· May 2021

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Design, synthesis and biological evaluation of naphthalenebenzimidizole platinum (II) complexes as potential antitumor agents.
Gui-Bin Liang, Yan-Cheng Yu, Jian-Hua Wei, Wen-Bin Kuang, Zhen-Feng Chen

Eur J Med Chem· February 2020

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Novel mutations in Chinese Han patients with tuberous sclerosis complex: Case series and review of the published work.
Li-Yun Zheng, Yu-Wei Lee, Yang Han, Li-Li Tang, Yu-Yan Cheng

J Dermatol· July 2018

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Design, synthesis and pharmacological evaluation of new 2-oxo-quinoline derivatives containing α-aminophosphonates as potential antitumor agents.
Yan-Cheng Yu, Wen-Bin Kuang, Ri-Zhen Huang, Yi-Lin Fang, Ye Zhang

Medchemcomm· June 2017

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Oxoaporphine Metal Complexes (Co, Ni, Zn) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2.
Jiao-Lan Qin, Wen-Ying Shen, Zhen-Feng Chen, Li-Fang Zhao, Qi-Pin Qin, Yan-Cheng Yu

Sci Rep· April 2017

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Stabilization of c-myc G-Quadruplex DNA, inhibition of telomerase activity, disruption of mitochondrial functions and tumor cell apoptosis by platinum(II) complex with 9-amino-oxoisoaporphine.
Jiao-Lan Qin, Qi-Pin Qin, Zu-Zhuang Wei, Yan-Cheng Yu, Ting Meng

Eur J Med Chem· November 2016

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Increased expression of IL-28RA mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.
Yu-Yan Cheng, Yu-Jun Sheng, Yan Chang, Yan Lin, Zheng-Wei Zhu

Clin Rheumatol· October 2015

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